Full Spectrum Enzyme Ingredients & Drug Interactions
by Konsyl
What is this page for?
First and foremost: checking Full Spectrum Enzyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Full Spectrum Enzyme is a dietary supplement by Konsyl with 19 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
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HelloPharmacist Scorecard of Full Spectrum Enzyme by Konsyl
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Full Spectrum Enzyme contains 19 active ingredients, mostly digestive enzymes. Bromelain (from pineapple) and several proteases (Acid-Stable Protease, Protease 4.5, Protease 6.0, and Neutral Bacterial Protease) break down proteins.
Lipase breaks down fats, while Lactase breaks down milk sugar. Other enzymes in the blend—Amylase, Cellulase, Hemicellulase, Pectinase, and others—target different types of carbohydrates and plant fibers.
The capsule also contains inactive ingredients: cellulose and MCT (medium-chain triglycerides).
Does it work?
Strong evidence
The evidence for what these enzymes can do isn't well established in the data we hold. Lactase—which breaks down milk sugar—is effective for lactose intolerance when taken as directed.
For the other ingredients, including bromelain, the proteases, lipase, and phytase, we have insufficient reliable evidence to rate how well they work for any condition. If you're considering this product for a specific health concern, it's worth talking it over with your doctor or pharmacist.
How safe is it?
Well-documented data
Overall, the enzymes in this product are generally well tolerated for most adults when used as directed, though some people may experience digestive upset (diarrhea, gas, stomach discomfort, nausea) or, rarely, allergic reactions. Bromelain is generally well tolerated short-term, but we have limited evidence on long-term safety.
People with serious digestive conditions should use this product only under medical guidance. During pregnancy, bromelain is not recommended because there isn't enough safety data.
The same applies to several of the proteases—safety hasn't been established, so they're best avoided unless prescribed. For breastfeeding, safety data are limited or unknown for most ingredients, so check with your doctor or pharmacist first.
Lactase, though, is likely safe during pregnancy and acts only in the gut, making it lower-risk—but still worth confirming with your healthcare provider if you're nursing.
Meds to double-check
Moderate interaction found
If you take blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel), check with your doctor or pharmacist before using this product—bromelain may increase your bleeding risk. Tetracycline antibiotics (like doxycycline or tetracycline) may have increased absorption when combined with bromelain, though the practical effect remains unclear.
If you're on any prescription medication, use the interaction checker on this page to see if it's affected.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Full Spectrum Enzyme is a multi-enzyme digestive supplement that's generally well tolerated, though it can cause digestive upset in some people. If you take blood thinners or antiplatelet drugs, or tetracycline antibiotics, you'll want to check with your doctor or pharmacist before starting it.
Anyone with serious digestive conditions, pregnant people, or nursing parents should talk it over with their healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 8 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Full Spectrum Enzyme, straight from the product label.
| Brand | Konsyl |
|---|---|
| Barcode (UPC) | 610858110600 |
| Net contents | 60 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 21, 2023 |
| DSLD ID | 272258 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Full Spectrum Enzyme by Konsyl, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Enzyme Blend | 460 mg | -- |
| Bromelain | 0 NP | -- |
| Acid Maltase | 0 NP | -- |
| Acid-Stable Protease 3.0 | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Amylase | 0 NP | -- |
| Protease 4.5 | 0 NP | -- |
| Protease 6.0 | 0 NP | -- |
| Lipase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Pectinase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Neutral Bacterial Protease | 0 NP | -- |
Other ingredients: Cellulose, MCT
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule with each meal.
Formula
Full Spectrum Enzyme is a potent proprietary combination of digestive enzymes produced through controlled fermentation of select microbial species and is stable throughout the pH range of the GI tract. This full-spectrum digestive support formula helps to optimize nutrient absorption by assisting in the breakdown of protein, carbohydrate and fat, as well as dairy, grains and indigestible fibers found in foods such as vegetables and beans.
Keto friendly
Formulation
In addition, Full Spectrum Enzymes is suitable for vegetarians.
Natural color variation may occur in this product.
Optimizes the nutritional value of foods full spectrum enzyme formula
Vegan
Helps support digestive health
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
Precautions
Caution: For adults only.
Consult physician if pregnant/nursing, taking medication or have a medical condition.
Keep out of reach of children.
Do not eat freshness packet. Keep in bottle.
Tamper Evident: Do not use if printed inner seal under cap is broken or missing
Produced in a GMP facility that processes other ingredients containing these allergens.
Storage
Store in a cool, dry place after opening.
FDA Disclaimer Statement
These statements have not ben evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Whole body health starts with your gut
Questions or comments? +1-410-822-5192 8:30 a.m. to 5 p.m. ET.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Copyright Konsyl Pharmaceuticals
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Full Spectrum Enzyme by Konsyl label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Full Spectrum Enzyme by Konsyl
These are the 19 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Enzyme Blend
- › Bromelain
- › Acid Maltase
- › Acid-Stable Protease 3.0
- › Cellulase
- › Amylase
- › Protease 4.5
- › Protease 6.0
- › Lipase
- › Hemicellulase
- › Alpha-Galactosidase
- › Lactase
- › Pectinase
- › Peptidase
- › Glucoamylase
- › Beta-Glucanase
- › Invertase
- › Phytase
- › Xylanase
- › Neutral Bacterial Protease
Other (inactive) ingredients: Cellulose, MCT. These complete the product’s ingredient list but are not active constituents.
Full Spectrum Enzyme by Konsyl Drug Interactions
HelloPharmacist Interaction Report
Full Spectrum Enzyme by Konsyl may interact with medications through its bromelain content.
The most serious interaction is with blood thinners and antiplatelet drugs (anticoagulants and antiplatelet medications): bromelain may increase bleeding risk if combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
Bromelain also has a minor interaction with tetracycline antibiotics. Laboratory research suggests bromelain might increase how your body absorbs these antibiotics, though a human study found no difference in antibiotic levels when taken together.
The effect remains theoretical and hasn't been clearly shown in practice.
Several other ingredients in this product—Acid Maltase, Cellulase, Amylase, Hemicellulase, Alpha-Galactosidase, Pectinase, Peptidase, Glucoamylase, Beta-Glucanase, Invertase, and Xylanase—we could not check for interactions because we hold no data on them. Altogether, these interactions span 141 individual medications.
Before you start, run your current medications through the checker on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Full Spectrum Enzyme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Full Spectrum Enzyme interact with 141 drugs. Click any drug to see the details.
1 of the 19 ingredients in Full Spectrum Enzyme interact with drugs. Each result below shows which ingredient is responsible. Bromelain
Amphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Amphotericin, Tetracycline interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Chlortetracycline interactionDemeclocyclineDeclomycin
How Demeclocycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Demeclocycline interactionDoripenemDoribax
How Doripenem interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Doripenem interactionDoxycyclineDoryx, Doxy, Doxy-D, Doxycin, Doxycycline Injection, Doxylin +6 more
How Doxycycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Doxycycline interactionDoxycycline HyclateActiclate, Acticlate Cap, Lymepak
How Doxycycline Hyclate interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Doxycycline Hyclate interactionDoxycycline MonohydrateErfacea
How Doxycycline Monohydrate interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Doxycycline Monohydrate interactionDoxycylineDoxychel
How Doxycyline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Doxycyline interactionEravacyclineXerava
How Eravacycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Eravacycline interactionMetronidazole, Tetracyline, Bismuth Subcitrate PotassiumPylera
How Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Metronidazole, Tetracyline, Bismuth Subcitrate Potassium interactionMinocycline HydrochlorideMinolira, Ximino
How Minocycline Hydrochloride interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Minocycline Hydrochloride interactionOmadacycline (iv)Nuzyra
How Omadacycline (iv) interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Omadacycline (iv) interactionOmadacycline (oral)Nuzyra
How Omadacycline (oral) interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Omadacycline (oral) interactionOxytetracyclineTerramycin
How Oxytetracycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Oxytetracycline interactionOxytetracycline, Phenazopyridine, SulfamethizoleUrobiotic
How Oxytetracycline, Phenazopyridine, Sulfamethizole interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Oxytetracycline, Phenazopyridine, Sulfamethizole interactionRetapamulinAltabax, Altargo
How Retapamulin interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Retapamulin interactionTetracyclineAchromycin, Achromycin V, Nor-Tet, Robitet, Sumycin, Sumycin 250 +6 more
How Tetracycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Tetracycline interactionTigecyclineTygacil
How Tigecycline interacts with Full Spectrum Enzyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainTetracycline Antibiotics Minor
Interaction Summary
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Read the full Bromelain + Tigecycline interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Full Spectrum Enzyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bromelain
Anticoagulant/Antiplatelet Drugs
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.
Tetracycline Antibiotics
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.
Brand information
Manufacturer and brand details for Full Spectrum Enzyme, from the product label.
Konsyl
See all Konsyl products- Name
- Konsyl Pharmaceuticals, Inc.
- City
- Easton
- State
- MD
- ZipCode
- 21601
- Phone Number
- 1-410-822-5192
- Web Address
- www.konsyl.com
Full Spectrum Enzyme by Konsyl: Common Questions
Does Full Spectrum Enzyme by Konsyl interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What side effects might I notice?
Does this product actually help with digestion?
How many active ingredients are in one capsule?
I'm allergic to pineapple. Should I avoid this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Full Spectrum Enzyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Full Spectrum Enzyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bromelain
Interacts with 141 drugsBromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...
Read the full Bromelain monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
Full Spectrum Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bromelain 19 references
- Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
- Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
- Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
- Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
- Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
- Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
- Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
- Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
- Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
- Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
- Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
- Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
- Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
- Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
- Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
- Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
- Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
- Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC