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Dietary supplement

GABA Ingredients & Drug Interactions

by AST Sports Science

GABA label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GABA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GABA is a dietary supplement by AST Sports Science with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gamma Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GABA by AST Sports Science

Ask about any prescription or over-the-counter medication and we check it for interactions with GABA by AST Sports Science — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GABA by AST Sports Science

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gamma aminobutyric acid (GABA), a compound your brain naturally makes that plays a role in calming nerve activity. The capsule itself has no other inactive fillers or binders listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gamma-aminobutyric Acid (gaba)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: growth hormone potentiator for muscle and strength.
  • We looked for evidence on: Athletic performance, muscle growth, body composition, recovery.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

The evidence we hold on GABA is not established enough to rate it. Studies haven't built a strong case for its use in anxiety, ADHD, athletic performance, cerebral palsy, or chronic bronchitis — the conditions it's marketed for.

That doesn't mean it doesn't work; it means the data we have doesn't support a confident claim either way yet.

The evidence, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, GABA is generally well tolerated in the short term, though some people report drowsiness, nausea, muscle weakness, or mild stomach or throat irritation. The long-term safety picture is unclear — it hasn't been studied thoroughly over time.

One isolated case reported a temporary stop in menstruation. There isn't enough safety information to recommend it unless your doctor advises otherwise, and the data advises against use while breastfeeding.

Side effects, ingredient by ingredient Gamma-aminobutyric Acid (gaba)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before starting if you take blood pressure medications (antihypertensives) — GABA may lower your blood pressure further. Also flag any sedatives, sleep aids, or other central nervous system depressants, as GABA may strengthen their drowsy effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GABA is one to discuss with your doctor or pharmacist if you take blood pressure medications or sedatives, because it may add to their effects. The evidence for what it actually does hasn't been nailed down yet.

If you're curious, talk it over with your own healthcare provider first — they'll know your full health picture and can tell you whether it fits.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GABA, straight from the product label.

Brand AST Sports Science
Barcode (UPC) 70577003151
Net contents 100 Gram(s); 3.53 Ounce(s); 180 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 73650
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GABA by AST Sports Science, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
36
UPC/BARCODE
70577003151
IngredientAmount% DV
Gamma Aminobutyric Acid3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

GH potentiator 36 servings Easy to swallow capsules Growth hormone potentiator Muscle Strength Recovery

The principle anabolic actions of growth hormone include the stimulation of amino acid transport, increased protein synthesis, reduction of body-fat and increase of muscle growth.

Made in USA

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

GABA is an amino acid classified as a neurotransmitter. Studies have shown supplementing with GABA increases growth hormone secretion.

AST Sports Science produces GABA under rigid quality control conditions. Each batch is HPLC certified and laboratory tested for purity and potency.

Copyright 2016 AST Sports Science

GABA is a naturally occurring amino acid classified as a neurotransmitter.

GABA is manufactured with the utmost care and highest standards in a NSF GMP certified facility.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

REV# GABA516

Suggested/Recommended/Usage/Directions

Recommended Use: For adults only. As a dietary supplement, take five (5) capsules approximately 30 minutes before sleep. Optional - take 3 to 5 capsules 30 minutes before workout.

Precautions

Some individuals may experience a minor tingling of the skin and/or slight shortness of breath shortly after taking GABA. This is a characteristic of this amino acid and quickly subsides.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GABA by AST Sports Science label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GABA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GABA by AST Sports Science

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Capsule(s) Dosage formCapsule Servings per container36 Amounts shown are per serving.

Gamma Aminobutyric Acid

Interacts with
419 drugs
3 Gram(s) per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma Aminobutyric Acid monograph & interactions
Interaction report

GABA by AST Sports Science Drug Interactions

Want to check YOUR meds against GABA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

Gamma Aminobutyric Acid 419

Individual Drug Interactions

The ingredients in GABA interact with 419 drugs. Click any drug to see the details.

1 of the 1 ingredient in GABA interact with drugs. Each result below shows which ingredient is responsible. Gamma Aminobutyric Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in GABA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gamma Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma Aminobutyric Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GABA, from the product label.

AST Sports Science

See all AST Sports Science products
Name
AST Sports Science
Street Address
120 Capital Drive
City
Golden
State
CO
ZipCode
80401
Phone Number
1-800-627-2788
Web Address
www.ast-ss.com
Pharmacist Counseling Corner

GABA by AST Sports Science: Common Questions

Does GABA by AST Sports Science interact with any medications?
Yes. Based on its ingredients, GABA has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GABA contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is GABA safe to take long-term?
Long-term safety hasn't been well studied, so we don't have good data on how it holds up over months or years. Stick with your doctor or pharmacist on whether it's right for you in the longer run.
Can I take GABA while breastfeeding?
The safety data advises against it — there isn't enough information to know it's safe while breastfeeding. Talk with your doctor or pharmacist about whether it's okay for your situation.
What are the most common side effects?
People taking GABA by mouth most often report drowsiness, nausea, stomach upset, muscle weakness, or mild throat irritation. A thorough safety review hasn't been done, so other effects might show up too.
Does GABA really work for anxiety?
The evidence isn't strong enough for us to say. Studies haven't built a solid case yet, so it's not clear whether it actually helps anxiety or not.
What is GABA supposed to do in this supplement?
GABA is a natural calming compound your brain makes. The supplement aims to provide extra GABA to support relaxation, though the evidence for whether oral supplements actually work that way is thin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GABA label
Go deeper

The Full Monographs Behind GABA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

GABA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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