Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Gamma E Tocopherol With Sesame Lignans Ingredients & Drug Interactions

by Life Extension

Gamma E Tocopherol With Sesame Lignans label
See full label image
Softgel Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gamma E Tocopherol With Sesame Lignans against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gamma E Tocopherol With Sesame Lignans is a dietary supplement by Life Extension with 3 active ingredients. Its ingredients are commonly taken for general antioxidant support, skin and hair care, heart health.Based on those ingredients, 1,073 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Sesame seed (Sesamum indicum) lignan extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gamma E Tocopherol With Sesame Lignans by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Gamma E Tocopherol With Sesame Lignans by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gamma E Tocopherol With Sesame Lignans by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Gamma-E Mixed Tocopherols” is listed as a grouped ingredient — the label gives one combined amount (359 mg) without saying how much of each component you get.

This product contains 6 active ingredients, all forms of vitamin E: vitamin E, beta-tocopherol, gamma-tocopherol, alpha-tocopherol, gamma-E mixed tocopherols (a blend of the tocopherols listed separately), and delta tocopherol. These tocopherols work as antioxidants in your body.

The product also includes sesame seed lignan extract, which contains compounds from sesame thought to offer additional antioxidant support. The softgel capsule also contains several inactive ingredients — gelatin, glycerin, purified water, silica, sunflower lecithin, carob color, and rosemary extract — that serve as the capsule shell and preservative.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vitamin E deficiency — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Ataxia with vitamin E deficiency (AVED) — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Vitamin E) (Natural Medicines).
  • On file: Beta-thalassemia — rated "Possibly Effective" (Vitamin E) (Natural Medicines).
  • On file: Glucose-6-phosphate dehydrogenase (G6PD) deficiency — rated "Possibly Effective" (Vitamin E) (Natural Medicines).

Vitamin E is effective for treating vitamin E deficiency and a rare genetic condition called AVED (ataxia with vitamin E deficiency). It's possibly effective for Alzheimer disease, beta-thalassemia, G6PD deficiency, and intracranial hemorrhage, though the evidence is not conclusive.

Sesame seed lignan extract is possibly effective for high blood pressure, but possibly ineffective for cough. The evidence is insufficient to rate it for nonalcoholic fatty liver disease, HIV/AIDS-related wasting, Alzheimer disease, or anemia of chronic disease.

The evidence, ingredient by ingredient Vitamin E Sesame

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E at usual dietary levels is generally well tolerated. However, the safety notes caution that high-dose long-term supplements may raise the risk of bleeding and other harms.

Serious but rare side effects from oral vitamin E include bleeding, hemorrhagic stroke, and cardiovascular complications. High doses in particular may increase bleeding risk if you have a vitamin K deficiency or take anticoagulant or antiplatelet drugs.

Sesame is a major allergen — allergic reactions ranging from skin rashes to breathing problems have been reported. One case of diarrhea was tied to sesame in a trial.

Because this product uses concentrated sesame extract rather than whole food, it's less well studied for safety. For pregnancy, vitamin E is rated possibly safe, but amounts from food and prenatal vitamins are appropriate; talk with your doctor before taking high-dose supplements.

For breastfeeding, vitamin E is likely safe at normal dietary amounts, though there's a possibly unsafe rating for high-dose supplements — check with your doctor or pharmacist first.

Side effects, ingredient by ingredient Vitamin E Sesame

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin E, Sesame.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,074 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (including warfarin) — vitamin E raises bleeding risk. Also flag blood pressure medications, diabetes drugs, chemotherapy (alkylating agents and antitumor antibiotics), selumetinib, and any drugs processed by CYP2C9 or CYP3A4 liver enzymes.

If you have a sesame allergy, avoid this product entirely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is geared toward people who want the antioxidant support of mixed vitamin E tocopherols combined with sesame lignans. If you take blood thinners, blood pressure meds, diabetes drugs, or certain chemotherapy drugs, this product isn't right for you without a conversation with your doctor or pharmacist first.

Even if you don't take medications, high-dose vitamin E can raise bleeding risk, so it's worth running your personal health history and prescription list past your doctor before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gamma E Tocopherol With Sesame Lignans, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870759065
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 70663
Product type Botanical With Nutrients
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gamma E Tocopherol With Sesame Lignans by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
737870759065
IngredientAmount% DV
Vitamin E45 IU150%
Beta-Tocopherol0 NP--
Gamma-Tocopherol0 NP--
Alpha-Tocopherol0 NP--
Gamma-E Mixed Tocopherols359 mg--
Delta Tocopherol0 NP--
Sesame seed (Sesamum indicum) lignan extract20 mg--

Other ingredients: Gelatin, Glycerin, purified Water, Silica, Sunflower Lecithin, Carob color, Rosemary extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed in a cool, dry place.

General Statements

13030359

Foundation for longer life

To report a serious adverse event event or obtain product information, contact 1-866-280-2852.

Read the entire label and follow the directions carefully prior to use.

Formula

Enhanced, natural form of Vitamin E

Contains soybeans.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains soybeans.

Warnings: -Keep out of reach of children.

-Do not exceed recommended dose. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Caution: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) softgel once or twice daily with food, or as recommended by a healthcare practitioner.

General

00759J

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gamma E Tocopherol With Sesame Lignans by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gamma E Tocopherol With Sesame Lignans label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gamma E Tocopherol With Sesame Lignans by Life Extension

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin E

Interacts with
764 drugs
45 IU per serving Form: D-Alpha-Tocopherol

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Gamma-E Mixed Tocopherols

Interacts with
764 drugs
359 mg per serving

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Gamma-E Mixed Tocopherols monograph & interactions

Sesame seed (Sesamum indicum) lignan extract

Interacts with
528 drugs
20 mg per serving

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds ca...

Sesame seed (Sesamum indicum) lignan extract monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Purified Water, Silica, Sunflower Lecithin, Carob color, Rosemary extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gamma E Tocopherol With Sesame Lignans by Life Extension Drug Interactions

Want to check YOUR meds against Gamma E Tocopherol With Sesame Lignans?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,073Drugs
1,010 Moderate 63 Minor

Ingredients driving the most interactions

Vitamin E 764
Sesame seed (Sesamum indicum) lignan extract 528

Individual Drug Interactions

The ingredients in Gamma E Tocopherol With Sesame Lignans interact with 1,073 drugs. Click any drug to see the details.

2 of the 3 ingredients in Gamma E Tocopherol With Sesame Lignans interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Sesame seed (Sesamum indicum) lignan extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gamma E Tocopherol With Sesame Lignans with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Sesame seed (Sesamum indicum) lignan extract5 drug types · 528 drugs

Antidiabetes Drugs

Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical studies show that sesame oil can decrease plasma glucose and glycated hemoglobin (HbA1c) levels. Some clinical research in patients taking glibenclamide shows that using sesame oil or a blend of sesame oil and rice bran oil in place of other oil for cooking reduces plasma glucose more than glibenclamide alone. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that replacing other cooking oil with sesame oil can lower systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with or without hypertension. There is also some evidence that sesame oil has additive effects in patients also taking atenolol, nifedipine, and/or hydrochlorothiazide. In patients using nifedipine, using a blend of sesame oil and rice bran oil for cooking reduces both SBP and DBP more than nifedipine alone.

Likelihood Probable Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.
In vitro, sesame inhibits CYP2C9. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, sesame might interfere with tamoxifen.
In animal research, sesame seed reduces the tumor-inhibitory effect of tamoxifen by reducing apoptosis and increasing proliferation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sesame might alter the transport of P-glycoprotein substrates.
In vitro research suggests that sesamin, a constituent of sesame, can inhibit the multi-drug transporter protein, P-glycoprotein. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sesame seed (Sesamum indicum) lignan extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gamma E Tocopherol With Sesame Lignans, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Gamma E Tocopherol With Sesame Lignans by Life Extension: Common Questions

Does Gamma E Tocopherol With Sesame Lignans by Life Extension interact with any medications?
Yes. Based on its ingredients, Gamma E Tocopherol With Sesame Lignans has a known interaction with 1,073 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gamma E Tocopherol With Sesame Lignans contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
No — vitamin E in this product interferes with how blood thinners work and raises your bleeding risk. Talk with your doctor or pharmacist before taking it; they may need to adjust your dose or monitor you more closely.
Will this help my blood pressure?
The sesame lignan extract in this product is possibly effective for high blood pressure, but vitamin E alone is not rated for that. If you're already on blood pressure medication, adding this supplement could lower your pressure further — check with your doctor first.
Does this product have a sesame allergy warning?
Yes. Sesame is a major allergen, and this product contains sesame seed lignan extract. If you have a sesame allergy, don't take it. Allergic reactions can range from skin rashes to breathing trouble.
Is it safe to take this while breastfeeding?
Vitamin E at normal dietary amounts is likely safe while breastfeeding, but safety data for high-dose supplements isn't clear — the facts note a possibly unsafe rating for high-dose use. Talk with your doctor or pharmacist about whether this product is appropriate for you.
What are the tocopherols in this product for?
Tocopherols are forms of vitamin E that work as antioxidants in your body. Vitamin E is effective for treating vitamin E deficiency and possibly helpful for Alzheimer disease, beta-thalassemia, and a few other conditions, though evidence for those uses is not definitive.
Does this product have any fillers?
It contains several inactive ingredients — gelatin, glycerin, water, silica, sunflower lecithin, carob color, and rosemary extract — that form the capsule and preserve the product. These are standard excipients, not fillers in the sense of inert bulk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gamma E Tocopherol With Sesame Lignans is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gamma E Tocopherol With Sesame Lignans label
Go deeper

The Full Monographs Behind Gamma E Tocopherol With Sesame Lignans’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Sesame

Interacts with 528 drugs

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds called lignans. Some early research sugges...

Read the full Sesame monograph →
Sources

Sources & How We Checked

Gamma E Tocopherol With Sesame Lignans's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 117 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
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