Garcinia Cambogia 50% HCA Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Garcinia Cambogia 50% HCA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Garcinia Cambogia 50% HCA is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite suppression, curbing sugar and carb cravings.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garcinia cambogia extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Garcinia Cambogia 50% HCA by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with Garcinia Cambogia 50% HCA by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Garcinia Cambogia 50% HCA by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is a single-ingredient supplement: garcinia cambogia extract standardized to 50% hydroxycitric acid (HCA). HCA is the active compound extracted from the fruit and rind of garcinia, a tropical plant.
The powder contains no other active ingredients — fillers or binders are not included.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that garcinia cambogia works for the claims commonly made about it. Effectiveness for athletic performance, obesity, high cholesterol (hyperlipidemia), and fatty liver disease (nonalcoholic fatty liver disease) all carry a rating of Insufficient Reliable Evidence To Rate, meaning the research available isn't strong enough yet to say whether it helps.
How safe is it?
Well-documented data
Garcinia is generally well tolerated in the short term, but caution is warranted because of rare reports of liver injury and hepatitis linked to its use. The most common side effects are diarrhea, stomach discomfort, headache, and nausea.
Serious adverse effects are rare but have included liver failure, mania (in which people experience reduced need for sleep, excessive spending, and agitation — particularly concerning in people with bipolar disorder), pancreatitis, and in one case, a severe heart muscle inflammation. Do not use this product during pregnancy or while breastfeeding — there isn't enough safety data.
Meds to double-check
Moderate interaction found
Before taking garcinia cambogia, talk with your doctor or pharmacist if you take any serotonergic drugs — antidepressants like escitalopram, sertraline, or fluoxetine (Moderate severity); blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate severity); diabetes medications like metformin or insulin (Moderate severity); or any drug known to stress the liver (Moderate severity). A documented case of serotonin syndrome occurred when garcinia was combined with an antidepressant, so this is not purely theoretical.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is best suited for people with no liver disease and no history of mania or bipolar disorder who aren't taking antidepressants, blood thinners, diabetes medications, or other drugs that affect the liver. Since garcinia carries real risks of drug interactions and rare but serious side effects, talk with your doctor or pharmacist before you start it, especially if you take any prescription medications or have liver or heart concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Garcinia Cambogia 50% HCA, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Net contents | 500 Gram(s); 17.64 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2021 |
| DSLD ID | 253279 |
| Product type | Botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Garcinia Cambogia 50% HCA by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Clean & pure bulk supplements US Standard Measuring Spoons Spoon Size (level) milligrams 1/16 teaspoon 190 1/8 teaspoon 380 1/4 teaspoon 760
Precautions
Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.
Consult your physician before use.
Keep out of reach of children!
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Free of: Sugar, soy, dairy, yeast, gluten or additives.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 500 mg (rounded 1/8 tsp) one to three times daily, or as directed by a physician.
Storage
Storage: Keep dry, cool & dark.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Garcinia Cambogia 50% HCA by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Garcinia Cambogia 50% HCA by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container1000 Amounts shown are per serving.
Garcinia cambogia extract
Interacts with704 drugs
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...
Garcinia cambogia extract monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Garcinia Cambogia 50% HCA by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
Garcinia Cambogia 50% HCA by BulkSupplements.com can interact with medications through its main active ingredient, hydroxycitric acid (HCA).
The most serious documented concern involves serotonergic drugs (antidepressants, certain pain relievers, and related medications) — there's a case report of a patient who developed serotonin syndrome, a potentially dangerous condition with confusion, rapid heartbeat, and high blood pressure, after combining garcinia extract with escitalopram, an antidepressant.
Read the full breakdown — every affected drug type, severity by severity
Additionally, garcinia may interact with blood thinners and antiplatelet drugs (like warfarin and aspirin) because HCA can inhibit how blood platelets clump together, theoretically raising bleeding risk. It also carries a Moderate concern with diabetes medications — the HCA in garcinia can lower blood sugar in animal studies, so combining it with insulin or other diabetes drugs might cause low blood sugar (hypoglycemia).
There's an additional Moderate-severity concern with drugs that can damage the liver (hepatotoxic drugs); rare cases of liver injury have been reported with garcinia use.
Although these are theoretical risks based on how the ingredient works, there's one documented case of a patient developing serotonin syndrome while taking garcinia and an antidepressant together. Altogether, these interactions span 705 individual medications.
Before you start this product, check your exact medications with the search tool on this page or talk with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Garcinia Cambogia 50% HCA?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Garcinia Cambogia 50% HCA interact with 704 drugs. Click any drug to see the details.
1 of the 1 ingredient in Garcinia Cambogia 50% HCA interact with drugs. Each result below shows which ingredient is responsible. Garcinia cambogia extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Extract + Abciximab interactionAbiraterone
How Abiraterone interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Garcinia Cambogia 50% HCA — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Garcinia Cambogia 50% HCA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Garcinia cambogia extract
Anticoagulant/Antiplatelet Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.
Antidiabetes Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.
Hepatotoxic Drugs
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.
Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Brand information
Manufacturer and brand details for Garcinia Cambogia 50% HCA, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Road
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
Garcinia Cambogia 50% HCA by BulkSupplements.com: Common Questions
Does Garcinia Cambogia 50% HCA by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is hydroxycitric acid, and why is it in this product?
Can I take this if I'm on an antidepressant?
What are the most common side effects?
Is this safe during pregnancy or breastfeeding?
Can I take this if I have diabetes?
Does this actually help with weight loss or cholesterol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Garcinia Cambogia 50% HCA is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Garcinia Cambogia 50% HCA’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Garcinia Cambogia 50% HCA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garcinia 44 references
- Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
- Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
- Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
- Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
- Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
- Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
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