Garcinia Cambogia Extract 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Garcinia Cambogia Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Garcinia Cambogia Extract 500 mg is a dietary supplement by Rx Select Nutraceuticals with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite suppression, curbing sugar and carb cravings.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garcinia cambogia fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals
Ask about any prescription or over-the-counter medication and we check it for interactions with Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: garcinia cambogia fruit extract at 500 mg per tablet. The extract's main compound is hydroxycitric acid (HCA), which is what researchers believe drives garcinia's effects.
The inactive ingredients—calcium carbonate, microcrystalline cellulose, stearic acid, croscarmellose sodium, film coat, magnesium stearate, and silica—are fillers and binders that hold the tablet together and help it dissolve.
Does it work?
Not established
The evidence for garcinia cambogia is limited. Our data shows insufficient reliable evidence to rate it for athletic performance, nonalcoholic fatty liver disease, hyperlipidemia (high cholesterol), or obesity.
While HCA has reduced blood sugar in animal studies, that effect hasn't been confirmed in people. If you're considering this supplement for any of those reasons, the science behind it isn't solid enough to say it will help.
How safe is it?
Well-documented data
Garcinia is generally well tolerated in the short term. The most common side effects are diarrhea, stomach upset, headache, and nausea—typically mild.
However, rare but serious adverse effects have been reported, including liver injury (sometimes severe enough to cause liver failure), mania (especially in people with bipolar disorder, usually appearing 1–8 weeks after starting), and in one documented case, heart inflammation. The safety data available is sparse, which is why it's not recommended during pregnancy or while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you're on any of the following: antidepressants and other serotonergic drugs (moderate risk of serotonin syndrome), blood thinners or antiplatelet agents like warfarin or aspirin (moderate risk of increased bleeding), diabetes medications (moderate risk of low blood sugar), or any drug known to affect your liver function (moderate risk of liver injury). No interactions are documented for ingredients we couldn't evaluate, but garcinia itself carries documented moderate-severity risks with these four medication types.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Garcinia cambogia may be worth a conversation with your doctor if you're interested in it for weight or metabolic support, but the evidence it actually works is weak. The bigger concern is its interactions with antidepressants, blood thinners, diabetes medications, and liver-affecting drugs—and the rare but real risk of liver damage.
If you take any prescription medication or have liver, heart, or mood concerns, talk with your own pharmacist or doctor before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Garcinia Cambogia Extract 500 mg, straight from the product label.
| Brand | Rx Select Nutraceuticals |
|---|---|
| Barcode (UPC) | 035046086930 |
| Net contents | 120 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Feb 23, 2018 |
| DSLD ID | 82482 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Garcinia cambogia fruit extract | 500 mg | -- |
Other ingredients: Calcium Carbonate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Film Coat, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
50% Hydroxycitric Acid
General Statements
Garcinia cambogia, the all-natural way to help reduce your appetite, burn more calories & suppress carbohydrate cravings
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
2013 Copyright Windmill Health Products All rights reserved.
Seals/Symbols
Made in the U.S.A.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 tablet up to three times daily, approximately 1 hour before a meal. Do not exceed 3 tablets per day.
Precautions
Keep out of reach of children.
Do not use if inner seal is broken.
Storage
Store at 15-30(0)C (59-86(0)F). Protect from heat, light and moisture.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
N8693
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.
Garcinia cambogia fruit extract
Interacts with704 drugs
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...
Garcinia cambogia fruit extract monograph & interactionsOther (inactive) ingredients: Calcium Carbonate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Film Coat, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals Drug Interactions
HelloPharmacist Interaction Report
Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals does interact with medications.
The main concern is its hydroxycitric acid (HCA) content, which can affect four different medication types.
Read the full breakdown — every affected drug type, severity by severity
The most serious documented risk involves serotonergic drugs (antidepressants and similar medications). In one case, a patient taking garcinia extract 1000 mg daily alongside escitalopram developed serotonin syndrome—a potentially dangerous condition marked by agitation, confusion, and rapid heart rate.
The theoretical risk is that garcinia might add to the effects of these medications and push you into serotonin toxicity.
You should also be cautious with blood thinners and antiplatelet drugs (like warfarin or aspirin), drugs for diabetes, and any medication that can affect your liver. HCA may increase bleeding risk, lower blood sugar more than intended, and potentially add stress to liver function—particularly important since garcinia itself has been linked to rare liver injury.
Altogether, these interactions span 705 individual medications.
Before you start this supplement, run your current medications through the interaction checker on this page. If you take an antidepressant, blood thinner, diabetes medication, or anything that affects your liver, check with your own doctor or pharmacist first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Garcinia Cambogia Extract 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Garcinia Cambogia Extract 500 mg interact with 704 drugs. Click any drug to see the details.
1 of the 1 ingredient in Garcinia Cambogia Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Garcinia cambogia fruit extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Extract + Abciximab interactionAbiraterone
How Abiraterone interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Fruit Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Garcinia Cambogia Extract 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit ExtractSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Garcinia Cambogia Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Garcinia cambogia fruit extract
Anticoagulant/Antiplatelet Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.
Antidiabetes Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.
Hepatotoxic Drugs
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.
Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Brand information
Manufacturer and brand details for Garcinia Cambogia Extract 500 mg, from the product label.
Rx Select Nutraceuticals
See all Rx Select Nutraceuticals products- Name
- Windmill Health Products
- Street Address
- 2900 Titan Row
- City
- Orlando
- State
- FL
- ZipCode
- 32809
Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals: Common Questions
Does Garcinia Cambogia Extract 500 mg by Rx Select Nutraceuticals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is garcinia cambogia supposed to do?
Can I take this while pregnant or breastfeeding?
What are the side effects?
Is garcinia safe if I have bipolar disorder?
Does this supplement have fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Garcinia Cambogia Extract 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Garcinia Cambogia Extract 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Garcinia Cambogia Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garcinia 44 references
- Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
- Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
- Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
- Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
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