Garlic & Parsley Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Garlic & Parsley against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Garlic & Parsley is a dietary supplement by NOW with 2 active ingredients. Its ingredients are commonly taken for high blood pressure, high cholesterol, heart health.Based on those ingredients, 1,028 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garlic Oil Concentrate, Parsley Oil Concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Garlic & Parsley by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Garlic & Parsley by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Garlic & Parsley by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: garlic oil concentrate and parsley oil concentrate. Garlic has been studied for its potential effects on blood pressure, cholesterol, and blood sugar, while parsley is traditionally used in herbal medicine for urinary and digestive support.
The softgels are made with soybean oil as the carrier and an inactive softgel capsule shell.
Does it work?
Moderate evidence
Garlic is possibly effective for diabetes, high blood pressure, heart disease prevention (atherosclerosis), liver fat buildup (NAFLD), and gum disease (periodontitis), based on the evidence we hold. Parsley's effectiveness isn't well established in the data we have—the available research is too limited to rate it for urinary tract infections, skin conditions, or joint health.
How safe is it?
Well-documented data
Garlic taken by mouth is generally well tolerated, though some people experience stomach upset, gas, bad breath, body odor, and nausea. Rare cases of allergic reaction have been reported; people allergic to raw garlic may tolerate cooked garlic better since some allergens break down with heat.
Parsley in food amounts is safe, but concentrated supplements and essential oils aren't well studied at high doses and should be avoided unless your doctor approves. Very high doses of parsley (well beyond what's in a supplement) have caused serious effects like anemia and blood cell disorders in rare cases.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you're on blood thinners (anticoagulants) or antiplatelet drugs like aspirin or warfarin—garlic and parsley both increase bleeding risk. Also flag diabetes medications, blood pressure drugs, protease inhibitors for HIV, tacrolimus or sirolimus for transplants, diuretics, pentobarbital, and any drug metabolized by CYP3A4, CYP2E1, or CYP1A2 enzymes.
These are common enzyme substrates; your pharmacist can check if your medications are among them.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with blood pressure, blood sugar, or liver health, but it's not right for you if you take blood thinners, diabetes meds, or certain heart and transplant drugs without checking first. Talk with your doctor or pharmacist before starting, especially if you're on any prescription medication or have bleeding concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Garlic & Parsley, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Garlic & Parsley by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Garlic Oil Concentrate | 2.3 mg | -- |
| Parsley Oil Concentrate | 2 mg | -- |
Other ingredients: Soybean Oil, Softgel Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
SUGGESTED USAGE: As a dietary supplement, take 2 softgels 1 to 2 times daily with meals. Consider taking these other NOW(R) products: Hawthorn Extract, Immune Renew(TM) and Chlorophyll.
Precautions
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Do Not Eat Freshness Packet. Keep in Bottle.
Caution: For adults only.
General Statements
For more product information visit www.nowfoods.com/1800
Please Recycle.
SOFTGEL SIZE Made in the USA
HERBAL SUPPLEMENT
Storage
Store in a cool, dry place after opening.
Brand IP Statement(s)
NOW(R) Garlic & Parsley delivers the natural nutrient profile found in Genuine Whole Foods. NOW(R)’s Garlic Oil is extracted and concentrated from the bulb of Allium sativum. It is equivalent to a whole garlic clove with no added fillers. Garlic has naturally occurring sulfur compounds, amino acids and trace minerals. Parsley Oil is added to this product to help reduce the natural garlic odor.
Seals/Symbols
Genuine Whole Food
GMP QUALITY ASSURED
FDA Statement of Identity
A Dietary Supplement
General
CODE 1800 V4
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Garlic & Parsley by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Garlic & Parsley by NOW
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Garlic Oil Concentrate
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Garlic Oil Concentrate monograph & interactionsParsley Oil Concentrate
Interacts with443 drugs
Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a...
Parsley Oil Concentrate monograph & interactionsOther (inactive) ingredients: Soybean Oil, Softgel Capsule. These complete the product’s ingredient list but are not active constituents.
Garlic & Parsley by NOW Drug Interactions
HelloPharmacist Interaction Report
NOW Garlic & Parsley contains garlic oil and parsley oil, both of which have documented interactions with medications.
The most serious concerns involve anticoagulants and antiplatelet drugs—garlic and parsley may both increase bleeding risk, and garlic specifically has reports of raising INR (a blood-thinning measure) in patients taking warfarin.
Read the full breakdown — every affected drug type, severity by severity
Garlic interacts with antihypertensive drugs (blood pressure medications), diabetes drugs, and several enzyme substrates—including CYP3A4 substrates (a broad category affecting many common medications), CYP2E1 substrates, protease inhibitors used for HIV, and tacrolimus used after transplants. Parsley adds interactions with CYP1A2 substrates, diuretics, barbiturates like pentobarbital, and sirolimus (another transplant drug).
Both may lower blood sugar, raising hypoglycemia risk with diabetes medications.
Parsley also contains vitamin K, which may reduce warfarin's effectiveness in large amounts. A Minor interaction exists between parsley and aspirin in people with parsley allergies.
Altogether, these interactions span 1,029 individual medications.
Use the medication checker on this page to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Garlic & Parsley?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Garlic & Parsley interact with 1,028 drugs. Click any drug to see the details.
2 of the 2 ingredients in Garlic & Parsley interact with drugs. Each result below shows which ingredient is responsible. Garlic Oil Concentrate Parsley Oil Concentrate
Aluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionParsley Oil ConcentrateAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amiloride, Hydrochlorothiazide interactionParsley Oil ConcentrateDiuretic Drugs Moderate
Interaction Summary
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Read the full Parsley Oil Concentrate + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amiodarone interactionAmitriptylineElavil
How Amitriptyline interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amitriptyline interactionParsley Oil ConcentrateCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley Oil Concentrate + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Parsley Oil ConcentrateCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley Oil Concentrate + Amitriptyline, Chlordiazepoxide interactionGarlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amitriptyline, Perphenazine interactionParsley Oil ConcentrateCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley Oil Concentrate + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Ammonium Chloride interactionParsley Oil ConcentrateDiuretic Drugs Moderate
Interaction Summary
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Read the full Parsley Oil Concentrate + Ammonium Chloride interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmprenavirAgenerase
How Amprenavir interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates, Protease Inhibitors (pis) Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Amprenavir interactionAmylase, Lipase, Protease (prescription Drug)Pancreatin 10, Pancron 10 Pancreatin
How Amylase, Lipase, Protease (prescription Drug) interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateProtease Inhibitors (pis) Moderate
Interaction Summary
Theoretically, garlic products containing allicin might decrease levels of PIs.
Read the full Garlic Oil Concentrate + Amylase, Lipase, Protease (prescription Drug) interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Anacaulase-bcdb interactionParsley Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Anagrelide interactionParsley Oil ConcentrateCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Read the full Parsley Oil Concentrate + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Parsley Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Anisindione interactionGarlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Parsley Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Parsley Oil Concentrate + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionGarlic Oil ConcentrateAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Garlic Oil Concentrate + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Parsley Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Antithrombin Iii interactionGarlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Antithrombin Iii interactionApalutamideErleada
How Apalutamide interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Apixaban interactionParsley Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Apixaban interactionApremilastOtezla
How Apremilast interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Aprepitant interactionAprocitentanTryvio
How Aprocitentan interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic Oil Concentrate + Aprocitentan interactionArgatrobanArgatroban
How Argatroban interacts with Garlic & Parsley — through 2 ingredients. Tap an ingredient for the detail:
Garlic Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Garlic Oil Concentrate + Argatroban interactionParsley Oil ConcentrateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Parsley Oil Concentrate + Argatroban interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Garlic & Parsley — through 1 ingredient. Tap an ingredient for the detail:
Garlic Oil ConcentrateCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Garlic Oil Concentrate + Aripiprazole interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Garlic & Parsley with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Garlic Oil Concentrate
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Parsley Oil Concentrate
Anticoagulant/Antiplatelet Drugs
Theoretically, parsley might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Animal research suggests that parsley has antiplatelet effects.
Antidiabetes Drugs
Theoretically, parsley might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that parsley might decrease blood glucose. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, parsley might increase serum levels of CYP1A2 substrates.
Laboratory research suggests that parsley can inhibit CYP1A2.
Diuretic Drugs
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Animal research suggests that parsley seed extract increases urine elimination. Parsley leaf and root might also interfere with diuretic therapy due their purported aquaretic effects.
Pentobarbital (Nembutal)
Theoretically, parsley might increase the duration of pentobarbital effects.
Animal research suggests that parsley juice prolongs the action of pentobarbital, perhaps by decreasing cytochrome P450 levels. It is not known if this occurs in humans or if this applies to other barbiturates or sedatives.
Sirolimus (Rapamune)
Theoretically, large quantities of parsley might increase sirolimus levels.
In one case report, an adult female with a history of kidney transplant presented with elevated blood sirolimus levels, approximately 4-7 times greater than previous measures, after daily consumption of a juice containing approximately 30 grams of parsley for 7 days. Sirolimus levels returned to normal a week after the parsley juice was discontinued.
Warfarin (Coumadin)
Theoretically, large amounts of parsley leaf and root might decrease the effects of warfarin.
Parlsey contains vitamin K.
Aspirin
Theoretically, aspirin might increase the severity of allergic reactions to parsley.
In one case, severe urticaria and swelling were reported after taking aspirin with parsley in an individual with a known mild parsley allergy.
Brand information
Manufacturer and brand details for Garlic & Parsley, from the product label.
NOW
See all NOW products- Name
- NOW FOODS
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
Garlic & Parsley by NOW: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Garlic & Parsley’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Garlic
Interacts with 989 drugsGarlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usually small. It is generally safe in food am...
Read the full Garlic monograph → Herb & supplement monographParsley
Interacts with 443 drugsParsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C. It is traditionally used as a diuretic and for digestion, but solid hu...
Read the full Parsley monograph →Sources & How We Checked
Garlic & Parsley's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 175 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garlic 154 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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