Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

GB-3 Ingredients & Drug Interactions

by Endo-met Laboratories

GB-3 label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GB-3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GB-3 is a dietary supplement by Endo-met Laboratories with 3 active ingredients. Its ingredients are commonly taken for digestive support, liver and gallbladder health, antioxidant support.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Radish extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GB-3 by Endo-met Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with GB-3 by Endo-met Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GB-3 by Endo-met Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GB-3 contains 3 active ingredients. Pancreatin is a digestive enzyme blend that helps break down food.

Black radish extract is derived from radish root, traditionally used for biliary and digestive support. Cholic acid is a bile acid that aids fat digestion and absorption.

The tablet also contains several inactive ingredients — microcrystalline cellulose, croscarmellose sodium, magnesium vegetable stearate, stearic acid, silicon dioxide, and a film coating — which help hold the tablet together and make it easier to swallow.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Radish's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: liver and gallbladder health support.
  • We looked for evidence on: Biliary disorders, hepatic function, bile flow, cholecystitis.
  • The closest evidence on file: Radish is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders (Natural Medicines).

The effectiveness evidence for GB-3's ingredients is limited. Black radish extract is rated as having insufficient reliable evidence for both biliary disorders and diabetes support — meaning the research we have isn't strong enough to say whether it works for those purposes.

Pancreatin and cholic acid effectiveness ratings are not on file in our data.

The evidence, ingredient by ingredient Radish

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Black radish is generally well tolerated in normal food amounts. However, concentrated radish supplements haven't been extensively studied for safety, and the facts advise caution with concentrated forms and unwashed raw sprouts.

Side effects from radish are uncommon but possible. A rare case of allergy (throat tightness and hives) has been reported.

Large amounts may irritate the stomach lining and cause mild indigestion, though it's unclear whether that's from radish alone or from other ingredients in the product. We have no pregnancy or breastfeeding safety data on file for any of the three active ingredients — talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while nursing.

Side effects, ingredient by ingredient Radish

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Radish.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medications to lower blood sugar), check with your doctor or pharmacist before starting GB-3 — black radish extract may increase the risk of low blood sugar. We could not check pancreatin or cholic acid for interactions, so run your full medication list through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

GB-3 is a digestive support tablet with three active ingredients, but the evidence for how well it works isn't established in our data. The main caution is if you take antidiabetes medication — black radish may lower blood sugar further.

Before you start, talk with your doctor or pharmacist about your medications and whether this product is a good fit for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GB-3, straight from the product label.

Brand Endo-met Laboratories
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 229077
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GB-3 by Endo-met Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
180
IngredientAmount% DV
Pancreatin160 mg--
Black Radish extract130 mg--
Cholic Acid112 mg--

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Vegetable Stearate, Stearic Acid, Silicon Dioxide, Film Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One tablet daily, or as directed by a physician. Am noon pm

Precautions

Notice: It is advisable to keep this and all supplements out of the reach of children.

FDA Statement of Identity

Ox bile, pancreatin, and black radish Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GB-3 by Endo-met Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GB-3 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GB-3 by Endo-met Laboratories

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pancreatin

160 mg per serving

Black Radish extract

Interacts with
86 drugs
130 mg per serving

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and it...

Black Radish extract monograph & interactions

Cholic Acid

112 mg per serving Form: Ox Bile

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Vegetable Stearate, Stearic Acid, Silicon Dioxide, Film Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

GB-3 by Endo-met Laboratories Drug Interactions

Want to check YOUR meds against GB-3?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Black Radish extract 86

Individual Drug Interactions

The ingredients in GB-3 interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in GB-3 interact with drugs. Each result below shows which ingredient is responsible. Black Radish extract

Each ingredient & the kinds of drugs it affects

For each ingredient in GB-3 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Radish extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, radish might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that radish extract, juice, and sprouts can reduce glucose levels. Animal research also shows that radish root juice 300 mg/kg reduces fasting and postprandial blood glucose in a rat model of diabetes, with effects similar to glibenclamide.

Likelihood Possible Evidence D
Black Radish extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GB-3, from the product label.

Endo-met Laboratories

See all Endo-met Laboratories products
Name
Endo-Met Laboratories, Inc.
City
Phoenix
State
AZ
ZipCode
85021
Pharmacist Counseling Corner

GB-3 by Endo-met Laboratories: Common Questions

Does GB-3 by Endo-met Laboratories interact with any medications?
Yes. Based on its ingredients, GB-3 has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GB-3 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does pancreatin do?
Pancreatin is a digestive enzyme blend that helps your body break down food so nutrients can be absorbed more easily.
Can I take GB-3 if I'm pregnant or breastfeeding?
We don't have safety data on file for any of the three active ingredients during pregnancy or lactation. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What's black radish extract used for?
Black radish extract has been traditionally used for biliary and digestive support, though the research evidence we have isn't strong enough yet to confirm it works for those purposes.
Can radish cause side effects?
Radish is generally well tolerated in food amounts. Rarely, some people have had allergic reactions (throat tightness, hives). Large amounts may irritate the stomach and cause mild indigestion.
Is GB-3 safe to take long-term?
Radish in normal food amounts is generally well tolerated. However, the long-term safety of concentrated radish supplements hasn't been well studied, so talk with your pharmacist about how long you plan to take it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GB-3 label
Go deeper

The Full Monographs Behind GB-3’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Radish

Interacts with 86 drugs

Radish is a common edible root vegetable that is nutritious and generally safe to eat as food. Some people use radish (especially black radish) and its extracts for digestion and liver suppo...

Read the full Radish monograph →
Sources

Sources & How We Checked

GB-3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Radish 5 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Damiani E, Aloia AM, Priore MG, Nardulli S, Ferrannini A. Generalized urticaria after ingestion of Raphanus sativus. Ann Allergy Asthma Immunol. 2011 Feb;106(2):168. PubMed
  3. Evans M, Paterson E, Barnes DM. An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects. BMC Complement Altern Med. 2014 Dec 9;14:475. PubMed
  4. Banihani SA. Radish (Raphanus sativus) and diabetes. Nutrients. 2017;9(9). pii: E1014. PubMed
  5. Shukla S, Chatterji S, Mehta S, Rai PK, Singh RK, Yadav DK, Watal G. Antidiabetic effect of Raphanus sativus root juice. Pharm Biol. 2011 Jan;49(1):32-7.

See these in context on the Radish monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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