Major interaction on record — check this product against your medications before combining. Based on 9 of 14 ingredients. Check your meds →
Dietary supplement

Genius Gamer Ingredients & Drug Interactions

by The Genius Brand

Genius Gamer label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Genius Gamer against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Genius Gamer is a dietary supplement by The Genius Brand with 14 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 927 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dicaffeine Malate, Theacrine, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Genius Gamer by The Genius Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Genius Gamer by The Genius Brand — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Genius Gamer by The Genius Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 14 of its 14 active ingredients.
  • “Dicaffeine Malate” is listed as a grouped ingredient — the label gives one combined amount (19 mg) without saying how much of each component you get.
  • “Vitashure” is listed as a grouped ingredient — the label gives one combined amount (21 mg) without saying how much of each component you get.

Genius Gamer contains 14 active ingredients. The product delivers three forms of caffeine—caffeine itself, methyliberine, and dicaffeine malate—each a stimulant that increases alertness and energy.

It also includes B vitamins (B1, B2, B3, B5, B6, and B12) that support energy metabolism and nervous system function. Citicoline (Cognizin) is included for brain health, alongside lutein and zeaxanthin, two pigments known to support eye health.

Theacrine is another stimulant compound, and N-acetyl-L-tyrosine is an amino acid that may support mental focus. The product contains several inactive ingredients—hypromellose, organic rice flour, organic rice, and ascorbyl palmitate—which are used as capsule material and flow agents.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gaming performance, focus and eye health.
  • We looked for evidence on: Attention, Cognitive function, Athletic performance, Age-related macular degeneration (AMD), Cataracts, Asthenopia (eye strain) — and 4 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD), Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Caffeine in this product is effective for mental alertness and likely effective for athletic performance. Vitamin B6 is effective for correcting B6 deficiency but is only possibly effective for pregnancy-related nausea.

Vitamin B3 is possibly effective for several conditions including acne and osteoarthritis. Citicoline is possibly effective for age-related cognitive decline and cataracts but is listed as possibly ineffective for stroke.

Lutein is possibly effective for age-related macular degeneration and cataracts. For theacrine, zeaxanthin, and vitamin B2, the evidence we hold is either insufficient to rate or no effectiveness data is on file.

The evidence, ingredient by ingredient Vitamin B6 Riboflavin Caffeine Citicoline Vitamin B12 Lutein Theacrine Niacinamide

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate doses is generally well tolerated in healthy adults, though high doses can cause serious side effects. Common side effects include anxiety, insomnia, nausea, tremors, and restlessness; stroke has been reported rarely.

Caffeine may pass small amounts into breast milk and has mixed safety data in pregnancy—some ratings say possibly safe, others say possibly unsafe, so talk with your doctor about your specific situation. Vitamin B6 is safe at normal food and supplement amounts but can damage nerves (sensory neuropathy) at very high doses over time.

Vitamin B3 is usually well tolerated at recommended doses but can cause nausea, rash, and other gastrointestinal issues at high doses. Vitamin B2 is very safe; excess is removed in urine.

Vitamin B12 is well tolerated with no established upper limit. Citicoline is generally well tolerated in studies, but long-term safety is not fully established, and it should be avoided in pregnancy and while breastfeeding due to insufficient safety data.

Lutein from food and typical supplement doses is safe for adults. Theacrine's long-term safety is not established, and it should be avoided in pregnancy and breastfeeding.

Zeaxanthin is well tolerated at typical supplement doses.

Side effects, ingredient by ingredient Vitamin B6 Riboflavin Caffeine Citicoline Vitamin B12 Lutein Theacrine Niacinamide

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 9 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Riboflavin, Caffeine, Theacrine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 927 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Genius Gamer, double-check with your doctor or pharmacist if you take ephedrine or related stimulants (Major severity risk), sedatives like pentobarbital, blood pressure medications, antipsychotics like clozapine, seizure medications (phenobarbital, carbamazepine, phenytoin), the antibiotic class quinolones, the ulcer drug cimetidine, amiodarone (a heart rhythm drug), blood thinners or antiplatelet drugs (especially warfarin), the seizure medication primidone, or diabetes medications. The stimulant content and multiple drug interactions mean your own healthcare provider needs to review this with you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Genius Gamer is a multi-ingredient energy and focus supplement built around caffeine, B vitamins, and brain-supportive compounds. It's aimed at people looking for a mental and physical performance boost, especially gamers and athletes.

However, the three forms of caffeine and the seizure-drug interactions make it important to check with your doctor or pharmacist before taking it, especially if you're on any medications. If you're pregnant or breastfeeding, talk with your provider first—some ingredients have mixed safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Genius Gamer, straight from the product label.

Brand The Genius Brand
Barcode (UPC) 850098008286
Net contents 80 Veggie Capsule(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 263199
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Genius Gamer by The Genius Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
80
UPC/BARCODE
850098008286
IngredientAmount% DV
Caffeine13.5 mg--
Vitamin B10.4 mg25%
Vitamin B60.5 mg25%
Vitamin B20.4 mg25%
N-Acetyl-L-Tyrosine88 mg--
Dicaffeine Malate19 mg--
Cognizin Citicoline50 mg--
Methyliberine16 mg--
Caffeine12.5 mg--
Vitamin B121.5 mg25%
Lutein5 mg--
Theacrine16 mg--
Vitamin B35 mg25%
Vitamin B52.5 mcg25%
Vitashure21 mg--
Zeaxanthin Isomer1 mg--

Other ingredients: Hypromellose, organic Rice Flour, organic Rice, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Genius Gamer is a formulation for serious Gamers looking for optimal performance. Gamers demand a lot from their brains - quick reactions, enhanced peripheral vision and rapid speed of thought throughout long periods of intense focus.

Brain Energy Increase Reaction Time Elite Gaming Performance Supplement

Formula

Containing premium ingredients Teacrine, Dynamine and Cognizin aimed at promoting performance athletes, driven professionals, intense gamers or anyone striving to perform at their peak. Genius Gamer also contains eye health nutrients which is critical for Gamers. Game on!

Containing premium ingredients Teacrine, Dynamine and Cognizin aimed at promoting performance athletes, driven professionals, intense gamers or anyone striving to perform at their peak. Genius Gamer also contains eye health nutrients which is critical for Gamers. Game on!

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, consume one (1) capsule with a glass of water or your favorite drink.

Brand IP Statement(s)

Infinergy Di-Caffeine Malate VitaShure Microencapsulated Caffeine Lutemax Lutein & Zeaxanthin Dynamine TeaCrine Cognizin TeaCrine is a registered trademark and protected by Patents Pending claiming priority to Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc. Dynamine is a trademark and protected by Patents Pending claiming priority to Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.

Precautions

Warnings: Do not exceed recommended dose. Not intended for use by persons with a medical condition.

Consult your physician before using this product if you are pregnant or nursing, or taking any medication. Do not use if you have high blood pressure or heart problems or are contemplating becoming pregnant.

Keep out of reach of children.

This product is manufactured in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and shellfish.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Genius Gamer by The Genius Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Genius Gamer label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Genius Gamer by The Genius Brand

These are the 14 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container80 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B1

0.4 mg per serving Form: Thiamine Hydrochloride

Vitamin B6

Interacts with
210 drugs
0.5 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B2

Interacts with
20 drugs
0.4 mg per serving Form: Riboflavin 5-Phosphate

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Vitamin B2 monograph & interactions

N-Acetyl-L-Tyrosine

88 mg per serving

Dicaffeine Malate

Interacts with
655 drugs
19 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Dicaffeine Malate monograph & interactions

Cognizin Citicoline

No known
interactions
50 mg per serving

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

Cognizin Citicoline monograph & interactions

Methyliberine

Interacts with
655 drugs
16 mg per serving

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredn...

Methyliberine monograph & interactions

Vitamin B12

Interacts with
20 drugs
1.5 mg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Lutein

No known
interactions
5 mg per serving Form: Lutemax 2020

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Theacrine

Interacts with
248 drugs
16 mg per serving

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studie...

Theacrine monograph & interactions

Vitamin B3

Interacts with
124 drugs
5 mg per serving Form: Niacinamide

Niacinamide (also called nicotinamide) is a form of vitamin B3 used in supplements and skin-care products. It is well established for preventing and t...

Vitamin B3 monograph & interactions

Vitamin B5

2.5 mcg per serving Form: D-Calcium Pantothenic Acid

Vitashure

21 mg per serving Form: Caffeine

Zeaxanthin Isomer

Interacts with
86 drugs
1 mg per serving Form: Lutemax

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin Isomer monograph & interactions

Other (inactive) ingredients: Hypromellose, Organic Rice Flour, Organic Rice, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Genius Gamer by The Genius Brand Drug Interactions

Want to check YOUR meds against Genius Gamer?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
927Drugs
8 Major 843 Moderate 76 Minor

Ingredients driving the most interactions

Dicaffeine Malate 655
Theacrine 248
Vitamin B6 210
Vitamin B3 124
Zeaxanthin Isomer 86

Individual Drug Interactions

The ingredients in Genius Gamer interact with 927 drugs. Click any drug to see the details.

7 of the 14 ingredients in Genius Gamer interact with drugs. Each result below shows which ingredient is responsible. Dicaffeine Malate Theacrine Vitamin B6 Vitamin B3 Zeaxanthin Isomer Vitamin B2 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Genius Gamer with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dicaffeine Malate41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Dicaffeine Malate full monograph & all 41 interactions

Theacrine1 drug type · 248 drugs

Cns Depressants

Theoretically, theacrine might alter the effects of CNS depressants.
Animal research shows that low doses of theacrine have sedating effects, whereas high doses might have stimulant effects. Depending on the dose of theacrine used, it might increase or decrease the effects of CNS depressants. However, these effects have not yet been reported in humans.

Likelihood Possible Evidence D
Theacrine full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B34 drug types · 124 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, niacinamide may have additive effects when used with anticoagulant or antiplatelet drugs, especially in patients on hemodialysis.
Several cases of thrombocytopenia have been reported for hemodialysis patients treated with niacinamide 1 gram daily. Hemodialysis patients receiving niacinamide had almost a three-fold higher risk of developing thrombocytopenia when compared with those receiving placebo.

Likelihood Unlikely Evidence D
Carbamazepine (Tegretol)

Niacinamide might increase the levels and adverse effects of carbamazepine.
Plasma levels of carbamazepine were increased in two children given high-dose niacinamide, 60-80 mg/kg/day. This might be due to inhibition of the cytochrome P450 enzymes involved in carbamazepine metabolism. There is not enough data to determine the clinical significance of this interaction.

Likelihood Possible Evidence D
Primidone (Mysoline)

Niacinamide might increase the levels and adverse effects of primidone.
Case reports in children suggest niacinamide 60-100 mg/kg/day reduces hepatic metabolism of primidone to phenobarbital, and reduces the overall clearance rate of primidone; however, there is not enough data to determine the clinical significance of this potential interaction.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacinamide may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 8.4 after taking niacinamide 500 mg twice daily for 10 days. The patient's INR was previously stable, ranging between 2 and 3, with no other changes to current medications or diet reported. The elevated INR returned to the therapeutic range after receiving vitamin K and discontinuing niacinamide.

Likelihood Possible Evidence D
Vitamin B3 full monograph & interactions

Zeaxanthin Isomer1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin Isomer full monograph & interactions

Vitamin B21 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Vitamin B2 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Genius Gamer, from the product label.

The Genius Brand

See all The Genius Brand products
Name
The Genius Brand
Street Address
2204 McFarland 400 Blvd
City
Alpharetta
State
GA
ZipCode
30004
Phone Number
1-888-498-9544
Web Address
TheGeniusBrand.com
Pharmacist Counseling Corner

Genius Gamer by The Genius Brand: Common Questions

Does Genius Gamer by The Genius Brand interact with any medications?
Yes. Based on its ingredients, Genius Gamer has a known interaction with 927 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Genius Gamer contains 14 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine? How much?
Yes—this product contains caffeine in three forms: caffeine itself, methyliberine, and dicaffeine malate. The product facts don't specify the total amount of caffeine per dose, so check the label or contact the manufacturer for the exact total.
Is it safe if I'm pregnant or breastfeeding?
The data on this is mixed. Caffeine ratings say possibly safe in pregnancy but also possibly unsafe, and small amounts do pass into breast milk. Citicoline, theacrine, and some B6 evidence advise against use in pregnancy and breastfeeding. Talk with your doctor or pharmacist about your situation—they can weigh the ingredients against your specific needs.
Can I take this if I'm on seizure medication?
Probably not without checking first. Caffeine may reduce the effectiveness of seizure drugs like phenobarbital and carbamazepine, and vitamin B6 at high doses can do the same with phenobarbital and phenytoin. Your doctor or pharmacist needs to review whether this product is safe for you.
What is citicoline for?
Citicoline is included for brain health. It's possibly effective for age-related cognitive decline and cataracts, but the evidence for other brain conditions like Alzheimer's disease and traumatic brain injury is insufficient to say either way.
Will this keep me awake?
Possibly—caffeine commonly causes insomnia and sleep disturbances, especially in people sensitive to stimulants. Theacrine, another ingredient, also has stimulant effects at higher doses, so this product may interfere with sleep if taken late in the day.
Does this product contain any fillers?
It contains several inactive ingredients: hypromellose, organic rice flour, organic rice, and ascorbyl palmitate. These are used as capsule material and to help the powder flow. Whether you consider these "fillers" depends on your definition, but they're standard in capsule supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Genius Gamer label
Go deeper

The Full Monographs Behind Genius Gamer’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...

Read the full Citicoline monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Theacrine

Interacts with 248 drugs

Theacrine is a caffeine-like compound found naturally in certain tea plants and is sold in supplements for energy, focus, and mood. Early human studies suggest it may give a stimulant-like b...

Read the full Theacrine monograph → Herb & supplement monograph

Niacinamide

Interacts with 124 drugs

Niacinamide (also called nicotinamide) is a form of vitamin B3 used in supplements and skin-care products. It is well established for preventing and treating vitamin B3 deficiency, and there...

Read the full Niacinamide monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Genius Gamer's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 343 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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Vitamin B6 32 references
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Riboflavin 5 references
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Citicoline 11 references
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Vitamin B12 30 references
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Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

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Theacrine 1 reference
  1. Xu JK, Kurihara H, Zhao L, Yao XS. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice. J Asian Nat Prod Res 2007;9(6-8):665-72.

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Niacinamide 22 references
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Zeaxanthin 4 references
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  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
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