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Dietary supplement

Gentian & Skullcap Capsules Ingredients & Drug Interactions

by Wise Woman Herbals

Gentian & Skullcap Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gentian & Skullcap Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gentian & Skullcap Capsules is a dietary supplement by Wise Woman Herbals with 2 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap, Gentian. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gentian & Skullcap Capsules by Wise Woman Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Gentian & Skullcap Capsules by Wise Woman Herbals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gentian & Skullcap Capsules by Wise Woman Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (960 mg) without saying how much of each component you get.

This product contains two active herbal ingredients: gentian and skullcap, delivered in a two-ingredient proprietary blend inside vegetarian capsules. Gentian is a root traditionally used for digestive support, though reliable evidence for its effects is limited.

Skullcap is an herb historically used for stress and nervousness, but clinical evidence supporting its effectiveness is also insufficient. The capsule itself is vegetarian.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish effectiveness for either ingredient. Gentian's uses — wound healing, weight management, sinus inflammation, and gastritis — all carry a rating of insufficient reliable evidence.

Skullcap shows the same: epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder are all rated insufficient reliable evidence. If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Gentian Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both herbs are generally tolerated in small amounts by healthy adults, though gentian can upset the stomach and is not well studied at high doses. Skullcap is often used short-term, but evidence is limited and product quality varies — use with care.

In trials, mild digestive disturbances occurred in around 9% of people taking skullcap at higher doses, and sedation or cognitive impairment was reported at doses of 200 mg or more. Gentian combined with other herbs has caused nausea, vomiting, diarrhea, and bloating in a small number of trial participants.

There is not enough safety data for gentian or skullcap during pregnancy or while breastfeeding — both are best avoided in these situations. If you're pregnant, planning pregnancy, or nursing, check with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Gentian Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Gentian, Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take any blood pressure medications — gentian may theoretically lower your blood pressure further. Also verify with them if you use any CNS depressants (sedatives, sleep aids, anxiety or pain medications with sedating effects) — skullcap can add to drowsiness and cognitive impairment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gentian & Skullcap may be worth trying if you're interested in traditional herbal support for digestion or stress, but the evidence for either ingredient working is insufficient. The bigger concern is that this product interacts with blood pressure medications and sedating drugs — if you take either type, check with your doctor or pharmacist first.

Pregnant or nursing? This isn't the right choice.

Talk to your healthcare provider about whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gentian & Skullcap Capsules, straight from the product label.

Brand Wise Woman Herbals
Barcode (UPC) 748840022195
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 284838
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gentian & Skullcap Capsules by Wise Woman Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
748840022195
IngredientAmount% DV
Proprietary Blend960 mg--
Gentian0 NP--
Skullcap0 NP--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules, 2-3 times per day with food.

Precautions

Caution: Keep out of the reach of children.

Warning: Cancer and reproductive harm. Www.P65Warnings.ca.gov

General Statements

Botanical formula

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry area away from direct sunlight with lid tightly sealed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gentian & Skullcap Capsules by Wise Woman Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gentian & Skullcap Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gentian & Skullcap Capsules by Wise Woman Herbals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

960 mg per serving

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gentian & Skullcap Capsules by Wise Woman Herbals Drug Interactions

Want to check YOUR meds against Gentian & Skullcap Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
419 Moderate

Ingredients driving the most interactions

Skullcap 248
Gentian 172

Individual Drug Interactions

The ingredients in Gentian & Skullcap Capsules interact with 419 drugs. Click any drug to see the details.

2 of the 2 ingredients in Gentian & Skullcap Capsules interact with drugs. Each result below shows which ingredient is responsible. Skullcap Gentian

Each ingredient & the kinds of drugs it affects

For each ingredient in Gentian & Skullcap Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap full monograph & interactions

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gentian & Skullcap Capsules, from the product label.

Wise Woman Herbals

See all Wise Woman Herbals products
Name
Wise Woman Herbals
City
Creswell
State
OR
ZipCode
97426
Phone Number
541.895.5152
Web Address
wisewomanherbals.com
Pharmacist Counseling Corner

Gentian & Skullcap Capsules by Wise Woman Herbals: Common Questions

Does Gentian & Skullcap Capsules by Wise Woman Herbals interact with any medications?
Yes. Based on its ingredients, Gentian & Skullcap Capsules has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gentian & Skullcap Capsules contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data for either gentian or skullcap in pregnancy or while breastfeeding, so both ingredients are best avoided in these situations. Talk with your doctor or pharmacist about alternatives.
What side effects might I experience?
Stomach upset is the most common concern — gentian can cause nausea, vomiting, diarrhea, or bloating, especially at higher doses or combined with other herbs. Skullcap may cause digestive disturbances (in about 9% of people at higher doses) and sedation or impaired thinking. Vivid dreams have been reported in isolated cases.
Does this actually work for stress or digestion?
The evidence we hold does not establish that either gentian or skullcap is effective for any condition — both are rated insufficient reliable evidence. If you're considering it for a specific reason, ask your doctor what the research actually supports.
Is this safe to use long-term?
Gentian is generally tolerated in small amounts but isn't well studied at high doses. Skullcap is typically used short-term, and product quality varies — use with care. If you're thinking of taking it regularly, check with your pharmacist or doctor first.
What's in the capsule besides the herbs?
The capsule itself is vegetarian — there are no other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gentian & Skullcap Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gentian & Skullcap Capsules label
Go deeper

The Full Monographs Behind Gentian & Skullcap Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Gentian & Skullcap Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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