Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

Gluten-Zyme Ingredients & Drug Interactions

by Country Life

Gluten-Zyme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gluten-Zyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gluten-Zyme is a dietary supplement by Country Life with 7 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gluten-Zyme by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Gluten-Zyme by Country Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gluten-Zyme by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Glutenase Proprietary Blend (Combination)” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Gluten-Zyme contains 12 active ingredients: a blend of live bacteria (probiotics including Lactobacillus helveticus, L. casei, L. rhamnosus, L. lactis, and Bifidobacterium lactis and B. brevis), digestive enzymes (amylase, glucoamylase, peptidase, and acid protease to break down carbohydrates, proteins, and other food components), marine polysaccharides, and a proprietary glutenase blend. The product also contains cellulose and magnesium stearate as inactive ingredients.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support metabolism of proteins associated with wheat and gluten.
  • We looked for evidence on: Diarrhea, Lactose intolerance, Gluten sensitivity, Wheat intolerance, Protein digestion.
  • The closest evidence on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Rotaviral diarrhea.

The evidence we hold doesn't establish that Lactobacillus helveticus works reliably for allergic rhinitis (hay fever), antibiotic-associated diarrhea, cognitive function, depression, rotaviral diarrhea, or exercise-induced respiratory infections—we have insufficient reliable evidence to rate it for any of these. We hold no effectiveness data for the other active ingredients in this product.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus helveticus is generally well tolerated in healthy people, but if you're seriously ill or immunocompromised, be cautious—there isn't enough reliable safety data, so check with your doctor before use. Because the product contains live microorganisms, there's a theoretical concern they could cause infection in vulnerable patients; most reported cases involve bacteria moving from places they naturally exist in the body.

Proteolytic enzymes (the acid protease here) are generally well tolerated but may cause digestive upset or allergic reactions in some people. Safety hasn't been established in pregnancy, and there's little data during breastfeeding—talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Gluten-Zyme if you're on antibiotic drugs (Moderate severity)—they can kill the live organisms in this product and reduce how well it works. Because we couldn't check several ingredients, it's a good idea to run all your medications through the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gluten-Zyme is a blend of probiotics and digestive enzymes, but we don't have solid evidence it works for most of the conditions it may be marketed for. The main concern is taking it with antibiotics, which can reduce the bacteria's effectiveness.

If you're immunocompromised, seriously ill, pregnant, or breastfeeding, talk with your doctor or pharmacist before starting—they can weigh the risks and benefits for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten-Zyme, straight from the product label.

Brand Country Life
Barcode (UPC) 015794053866
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Dec 22, 2017
DSLD ID 81147
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten-Zyme by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
015794053866
IngredientAmount% DV
Maltodextrin0 NP--
L. casei0 NP--
L. rhamnosus0 NP--
L. lactis0 NP--
L. helveticus0 NP--
Amylase0 NP--
Glucoamylase0 NP--
Marine Polysaccharides0 NP--
Peptidase0 NP--
B. lactis0 NP--
Acid Protease0 NP--
Glutenase Proprietary Blend (Combination)400 mg--
B. brevis0 NP--
Probiotic Blend0 NP--

Other ingredients: Cellulose, Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

This product is designed to support the metabolism of proteins often associated with wheat and gluten.

Yes Recyclable packaging Yes Manufacturing supports wind power

H.U.T. Hemoglobin Unit Tyrosine G.T.G.U. Glutamyl-Tyrosyl-Glutamic Unit A.G.U. Amyloglucosidase Unit C.F.A.U. Casein-Folin A Unit L.A.P.U. Leucine Aminopeptidase Unit D.U. Dextrin Units

This product has been manufactured at a GMP Registered facility.

Established 1971

Our pledge of integrity Authenticity Cleanliness Freshness Consistency Accuracy

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Yes Certified gluten-free by GFCO.org

Yes Certified vegan by the AVA

No Wheat, soy or milk No Salt or preservatives No Artificial colors, flavors or sweeteners No GMOs

Dairy-free Certified Gluten-free

Precautions

Caution: If you are pregnant or nursing, taking medication or planning a surgery, consult your doctor before using this product.

If you have Celiac Disease or Non-Celiac Gluten Sensitivity, consult your doctor before using this product. If any adverse reactions occur, stop taking the product and consult your doctor.

Do not accept if seal is broken.

Keep out of the reach of children.

As a reminder, discuss the supplements and medications that you take with your health care providers.

Storage

Store in a dry place between 59(0)-86(0) F

General

Product No. 5386 12D16NL

Formula

Includes Protease, Amylase and Glucoamylase

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take two (2) capsules prior to a meal up to three times a day.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gluten-Zyme by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gluten-Zyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gluten-Zyme by Country Life

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glutenase Proprietary Blend (Combination)

400 mg per serving

Other (inactive) ingredients: Cellulose, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten-Zyme by Country Life Drug Interactions

Want to check YOUR meds against Gluten-Zyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Gluten-Zyme interact with 182 drugs. Click any drug to see the details.

1 of the 7 ingredients in Gluten-Zyme interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Gluten-Zyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gluten-Zyme, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

Gluten-Zyme by Country Life: Common Questions

Does Gluten-Zyme by Country Life interact with any medications?
Yes. Based on its ingredients, Gluten-Zyme has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gluten-Zyme contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gluten-Zyme while I'm on antibiotics?
Not without checking with your doctor first. Antibiotics can kill the live bacteria in this product and make it less effective. Your doctor or pharmacist can tell you whether to skip it during antibiotics or space the doses apart.
Is Gluten-Zyme safe if I'm immunocompromised?
No—people who are seriously ill or have weakened immune systems should be cautious and only use it under a doctor's guidance. There's a theoretical risk that the live organisms could cause infection in vulnerable people.
Can I take this while pregnant or breastfeeding?
The proteolytic enzymes (proteases) in this product have not been studied enough in pregnancy to say it's safe—talk with your doctor or pharmacist. There's also little safety data during breastfeeding, so medical advice is important before use.
What does the acid protease do in this product?
Acid protease is a digestive enzyme that helps break down proteins in food so your body can absorb them better.
Does this product have any fillers?
Yes—it contains cellulose and magnesium stearate as inactive ingredients. These are binders and flow agents that help form the capsule.
Does Gluten-Zyme actually work for digestive issues?
We don't have reliable evidence that the probiotics in this product work for the conditions listed. The effectiveness data is insufficient for most of them, so talk with your doctor about whether it makes sense for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten-Zyme is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten-Zyme label
Go deeper

The Full Monographs Behind Gluten-Zyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Gluten-Zyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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