Major interaction on record — check this product against your medications before combining. Based on 6 of 12 ingredients. Check your meds →
Dietary supplement

GMC2 for Humans Ingredients & Drug Interactions

by Osumex

GMC2 for Humans label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GMC2 for Humans against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

GMC2 for Humans is a dietary supplement by Osumex with 12 active ingredients. Its ingredients are commonly taken for osteoarthritis, joint pain and stiffness, cartilage support.Based on those ingredients, 1,264 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Boswellia serrata resin extract, Flaxseed Oil, Glucosamine Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GMC2 for Humans by Osumex

Ask about any prescription or over-the-counter medication and we check it for interactions with GMC2 for Humans by Osumex — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of GMC2 for Humans by Osumex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 9 of its 10 active ingredients.

Osumex GMC2 for Humans contains 10 active ingredients. The main ones are two forms of glucosamine—glucosamine sulfate and glucosamine HCl—which support joint structure, plus chondroitin sulfate, which works alongside glucosamine to help maintain cartilage.

The formula also includes collagen for structural support, Boswellia serrata resin extract (an herbal anti-inflammatory), flaxseed oil (a source of omega-3s), yucca, manganese (a mineral), and fat. The inactive ingredients—natural flavors, fructose, xanthan gum, stevia extract, grape skin extract, and potassium sorbate—serve as flavoring, texture, and preservative.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: healthy joint protection and cartilage growth.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Kashin-Beck disease, cartilage degeneration, joint stiffness — and 1 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Chondroitin Sulfate is rated "Possibly Effective" for Osteoarthritis.

Glucosamine sulfate and glucosamine HCl are both likely effective for osteoarthritis, though quality and benefit vary between products. Chondroitin sulfate is possibly effective for both osteoarthritis and cataracts.

Boswellia serrata is possibly effective for osteoarthritis as well. Flaxseed oil has been rated possibly ineffective for obesity, rheumatoid arthritis, bipolar disorder, and high cholesterol.

For yucca and manganese's other uses listed in this formula—joint pain, allergic rhinitis, and osteoporosis—the evidence is insufficient to rate their effectiveness. The evidence for this product's ability to address aging skin, back pain, liver disease, and other conditions is not established in our data.

The evidence, ingredient by ingredient Glucosamine Chondroitin Sulfate Boswellia Serrata Flaxseed Oil Yucca Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucosamine and chondroitin are generally well tolerated when taken by mouth, though common mild side effects include bloating, constipation, cramps, diarrhea, heartburn, and nausea. Allergic reactions are a concern for sensitive individuals; one review found that about 72% of glucosamine-related adverse events involved hypersensitivity reactions, ranging from mild (itching, hives, lip swelling) to rare severe cases (including anaphylaxis in 1.5%) and rare asthma exacerbations.

Boswellia serrata and flaxseed oil are also generally well tolerated at normal doses; Boswellia may cause headache, dizziness, abdominal pain, or diarrhea, while flaxseed oil may cause loose stools or diarrhea at high doses. Manganese is safe in normal dietary amounts, but high-dose supplements carry a rare risk of nerve damage and Parkinson-like symptoms.

Pregnancy: safety data for glucosamine and chondroitin in pregnancy is insufficient, so these are best avoided; Boswellia and yucca safety data is also insufficient; flaxseed oil is possibly safe; and manganese amounts in prenatal vitamins are appropriate, but avoid high-dose supplements. Breastfeeding: safety data is insufficient for glucosamine, chondroitin, Boswellia, and yucca, so avoid unless your doctor advises; flaxseed oil has limited data but may be used with medical advice; and manganese is likely safe at normal dietary levels but avoid high-dose supplements.

Side effects, ingredient by ingredient Glucosamine Chondroitin Sulfate Boswellia Serrata Flaxseed Oil Yucca Manganese

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Boswellia Serrata, Manganese, Chondroitin Sulfate, Glucosamine, Flaxseed Oil.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,265 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Osumex GMC2 for Humans, check with your doctor or pharmacist if you take any of these: blood thinners (anticoagulants) like warfarin—the glucosamine and chondroitin may increase bleeding risk; cancer drugs that target topoisomerase II (such as etoposide or doxorubicin); antipsychotics; immunosuppressants; blood pressure-lowering drugs; other blood thinners or antiplatelet drugs; diabetes medications; acetaminophen (Tylenol); quinolone or tetracycline antibiotics; or ezetimibe (Zetia). This is not a complete list—use the medication checker on this page with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is designed mainly for osteoarthritis support through its glucosamine, chondroitin, and Boswellia content. If you take blood thinners like warfarin, diabetes medications, antipsychotics, antibiotics, blood pressure drugs, or immunosuppressants, talk with your doctor or pharmacist before starting—several ingredients can interact with these.

Pregnant or breastfeeding individuals should also check with their healthcare provider, since safety data for most ingredients is limited. Quality and benefit vary by product, so it's worth discussing with your own healthcare provider whether this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GMC2 for Humans, straight from the product label.

Brand Osumex
Net contents 10 Fluid Ounce(s); 300 mL
Market status On market
Date entered into DSLD Sep 24, 2021
DSLD ID 255218
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GMC2 for Humans by Osumex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 mL
Maximum serving Sizes:
10 mL
Servings per container
30
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Sugar1 Gram(s)--
Protein360 Gram(s)9%
Glucosamine Sulfate500 mg--
Fat0 Gram(s)--
Methylsulfonylmethane200 mg--
Glucosamine HCl1000 mg--
Chondroitin Sulphate200 mg--
Collagen400 mg--
Boswellia serrata resin extract60 mg--
Flaxseed Oil50 mg--
Yucca20 mg--
Manganese2 mg98.3%

Other ingredients: Natural flavours, Fructose, Xanthan Gum, purified Stevia extract, Grape skin extract, Potassium Sorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Superior quality liquid joint care

GMC2 liquid joint care is designed for healthy joint protection and promotes cartilage growth to give joint flexibility and mobility and to case joint pain.

Formula

GMC2 for humans Glucosamine MSM Chondroitin Collagen (30-day supply)

GMC2 contains bioavailable forms of the following amino acids: Alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, hydroxyprolone, leucine isoleucine, cystine, lysine, hydroxylysine, methionine, phenylalanine, proline, serine, threonine, tyrosine, valine

Suggested/Recommended/Usage/Directions

Also use Osumex 100% Pure Antarctic Krill Oil vegetable softgel capsules with GMC2 for faster and more effective results.

Directions for use: Shake well before using. For best results double daily dose for first 10 days. Can be taken anytime, but best after meals for user with sensitive stomach.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

New improved formula

Osumex The natural way to better health

Precautions

Warning: If pregnant or lactating, consult your doctor before use.

For dietary supplement use only.

Keep out of reach of children.

Do not use if seal is broken or missing. If complications discontinue use. Use as directed.

Contains shellfish.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GMC2 for Humans by Osumex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GMC2 for Humans label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GMC2 for Humans by Osumex

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Protein

360 Gram(s) per serving

Glucosamine Sulfate

Interacts with
170 drugs
500 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine Sulfate monograph & interactions

Fat

0 Gram(s) per serving

Methylsulfonylmethane

200 mg per serving

Glucosamine HCl

Interacts with
170 drugs
1000 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine HCl monograph & interactions

Chondroitin Sulphate

Interacts with
2 drugs
200 mg per serving

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain....

Chondroitin Sulphate monograph & interactions

Collagen

400 mg per serving

Boswellia serrata resin extract

Interacts with
952 drugs
60 mg per serving

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

Boswellia serrata resin extract monograph & interactions

Flaxseed Oil

Interacts with
293 drugs
50 mg per serving Form: Omega-3 Fatty Acids

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...

Flaxseed Oil monograph & interactions

Yucca

No known
interactions
20 mg per serving

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-in...

Yucca monograph & interactions

Manganese

Interacts with
83 drugs
2 mg per serving Form: Manganese Sulphate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Other (inactive) ingredients: Natural flavours, Fructose, Xanthan Gum, Purified Stevia extract, Grape skin extract, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

GMC2 for Humans by Osumex Drug Interactions

Want to check YOUR meds against GMC2 for Humans?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,264Drugs
2 Major 1,193 Moderate 69 Minor

Ingredients driving the most interactions

Boswellia serrata resin extract 952
Flaxseed Oil 293
Glucosamine Sulfate 170
Manganese 83
Chondroitin Sulphate 2

Individual Drug Interactions

The ingredients in GMC2 for Humans interact with 1,264 drugs. Click any drug to see the details.

5 of the 12 ingredients in GMC2 for Humans interact with drugs. Each result below shows which ingredient is responsible. Boswellia serrata resin extract Flaxseed Oil Glucosamine Sulfate Manganese Chondroitin Sulphate

Each ingredient & the kinds of drugs it affects

For each ingredient in GMC2 for Humans with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Boswellia serrata resin extract6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
Boswellia serrata resin extract full monograph & interactions

Flaxseed Oil3 drug types · 293 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.

Likelihood Possible Evidence D
Ezetimibe (Zetia)

Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.

Likelihood Probable Evidence B
Flaxseed Oil full monograph & interactions

Glucosamine Sulfate4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine Sulfate full monograph & interactions

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions

Chondroitin Sulphate1 drug type · 2 drugs

Warfarin (Coumadin)

Taking chondroitin in combination with glucosamine might increase the anticoagulant effects of warfarin. However, the effect of chondroitin alone is unclear.
There have been multiple reports of increased international normalized ratio (INR) in patients taking warfarin with glucosamine, with or without chondroitin. The lack of reports with chondroitin alone seem to suggest that the interactions occurring in these reports may have been due to glucosamine. In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in INR in patients previously stabilized on warfarin. Additionally, 20 voluntary case reports to the US Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone, without chondroitin, to increased INR in patients taking warfarin.

Likelihood Unlikely Evidence D
Chondroitin Sulphate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GMC2 for Humans, from the product label.

Osumex

See all Osumex products
Name
Osumex Natural Alternatives Ltd.
City
Oakville
State
ON
Phone Number
1-905-339-2686
Web Address
www.gsamine.com
Pharmacist Counseling Corner

GMC2 for Humans by Osumex: Common Questions

Does GMC2 for Humans by Osumex interact with any medications?
Yes. Based on its ingredients, GMC2 for Humans has a known interaction with 1,264 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GMC2 for Humans contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
Safety data is limited for most ingredients in this formula. Glucosamine, chondroitin, Boswellia, and yucca should be avoided in pregnancy due to insufficient safety information. Flaxseed oil is possibly safe in pregnancy, and manganese in normal amounts (like those in prenatal vitamins) is fine, but avoid high-dose supplements. While breastfeeding, safety is unclear for glucosamine, chondroitin, Boswellia, and yucca; flaxseed oil may be used with medical advice; and normal manganese intake is likely safe. Talk with your doctor or pharmacist for personalized guidance.
Can I take this with warfarin or other blood thinners?
Both forms of glucosamine in this product may increase warfarin's blood-thinning effects and raise your bleeding risk, based on case reports. Flaxseed oil can also add to blood-thinning effects. Do not start this product without clearing it with your doctor or pharmacist first if you take warfarin or any other blood thinner or antiplatelet drug.
What side effects might I experience?
The most common ones are mild digestive issues—bloating, constipation, cramps, diarrhea, heartburn, and nausea. At high doses, flaxseed oil may cause loose stools or diarrhea. Allergic reactions are rare but possible; signs include itching, hives, lip swelling, difficulty breathing, or (very rarely) anaphylaxis. Boswellia may cause headache or dizziness. Stop and seek medical help if you have any allergic or severe symptoms.
Will this actually help my joint pain or osteoarthritis?
Glucosamine sulfate and glucosamine HCl are likely effective for osteoarthritis, and chondroitin sulfate and Boswellia serrata are possibly effective for it as well. However, quality and benefit vary widely between products. For other uses like back pain, the evidence is insufficient. Talk with your doctor about whether this product is right for your specific situation.
Does this interact with diabetes medication?
Glucosamine has historically raised concerns about worsening diabetes, but current evidence suggests it is unlikely to interfere with diabetes drugs. Still, if you take diabetes medication, mention this product to your doctor or pharmacist so they can monitor you.
Can I take this if I'm on antibiotics?
Manganese in this product may reduce the absorption of quinolone antibiotics (like ciprofloxacin) and tetracycline antibiotics (like doxycycline), potentially making them less effective. If you are prescribed one of these antibiotics, check with your doctor or pharmacist about timing or whether you should pause this supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GMC2 for Humans label
Go deeper

The Full Monographs Behind GMC2 for Humans’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Chondroitin Sulfate

Interacts with 2 drugs

Chondroitin sulfate is a naturally occurring building block of cartilage that is widely taken, often with glucosamine, for osteoarthritis joint pain. The evidence is mixed—some people report...

Read the full Chondroitin Sulfate monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph → Herb & supplement monograph

Flaxseed Oil

Interacts with 293 drugs

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...

Read the full Flaxseed Oil monograph → Herb & supplement monograph

Yucca

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for t...

Read the full Yucca monograph → Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

GMC2 for Humans's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 141 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
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Chondroitin Sulfate 22 references
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Flaxseed Oil 21 references
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  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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