Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Golden Book Teapills Ingredients & Drug Interactions

by Plum Flower

Golden Book Teapills label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Golden Book Teapills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Golden Book Teapills is a dietary supplement by Plum Flower with 8 active ingredients. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 1,451 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Paeonia suffruticosa Bark, Root Extract, Cinnamomum cassia Bark Extract, Poria cocos Sclerotium Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Golden Book Teapills by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Golden Book Teapills by Plum Flower — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Golden Book Teapills by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,360 mg) without saying how much of each component you get.

Golden Book Teapills contains 8 ingredients, including a proprietary extract blend and seven other botanical extracts. The active ingredients are Rehmannia Root Extract, Poria Mushroom Sclerotium Extract, Cassia Cinnamon Bark Extract, Alisma Rhizome Extract, Dioscorea Rhizome Extract, Cornus Fruit Extract, Peony Root and Bark Extract, and Aconite Root Extract.

These are traditional Chinese medicinal plants combined in tablet form. The product also contains inactive ingredients (magnesium silicate, dextrin, and China wax) that serve as binders and stabilizers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chronic kidney disease (CKD) — rated "Possibly Effective" (Rehmannia) (Natural Medicines).

The evidence supporting these ingredients for any specific health condition is limited in our data. Rehmannia is rated possibly effective for chronic kidney disease, but the other ingredients—Poria mushroom, cassia cinnamon, peony, and aconite—show insufficient reliable evidence for the conditions they're traditionally used for, including diabetes, fatigue, and various other health concerns.

We don't hold effectiveness ratings for Alisma, Dioscorea, or Cornus in our database.

The evidence, ingredient by ingredient Rehmannia Poria Mushroom Cassia Cinnamon American Dogwood Peony Aconite

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several of these ingredients carry significant safety concerns. Aconite is extremely toxic and can be fatal even in small doses—it should not be used at all during pregnancy or while breastfeeding.

Rehmannia and Poria Mushroom have limited human safety data; the facts advise against both during pregnancy and breastfeeding. Cassia cinnamon in food amounts is generally considered safe, but high-dose supplement forms over time may harm the liver due to coumarin content; avoid medicinal doses in pregnancy and breastfeeding.

Peony is generally well tolerated for short-term use but lacks high-quality safety data; it's not recommended during pregnancy or breastfeeding. Rarely, peony may cause gastrointestinal upset (abdominal bloating, nausea, diarrhea, or loss of appetite), and a rash has been reported with cassia cinnamon.

Side effects, ingredient by ingredient Rehmannia Poria Mushroom Cassia Cinnamon American Dogwood Peony Aconite

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Peony, Poria Mushroom, Aconite, Cassia Cinnamon, Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,452 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Golden Book Teapills, check with your pharmacist if you take anticoagulants or antiplatelet drugs (blood thinners like warfarin or aspirin), antidiabetes medications, antihypertensive drugs (blood pressure medications), sedatives or sleep aids, drugs metabolized by CYP1A2 or CYP3A4 liver enzymes (including clozapine), estrogen replacement therapy or birth control, medications affecting acetylcholine (anticholinergic or cholinergic drugs), phenytoin (Dilantin) for seizures, or any hepatotoxic (liver-damaging) medications. Aconite in particular poses a serious toxicity risk and interacts with blood thinners and stimulants.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This is a complex traditional formula with multiple ingredients that interact with common medications, especially blood pressure and diabetes drugs, blood thinners, sedatives, and certain psychiatric medications. If you take any prescription drugs—particularly for blood pressure, blood sugar, heart conditions, or sleep—talk to your pharmacist before starting.

Pregnant and breastfeeding individuals should avoid this product due to limited safety data and the high toxicity risk from aconite. A pharmacist can check your exact medications against the complete interaction list on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Golden Book Teapills, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934856499
Net contents 1000 Pill(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 310599
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Golden Book Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Pill(s)
Maximum serving Sizes:
8 Pill(s)
Servings per container
125
UPC/BARCODE
739934856499
IngredientAmount% DV
Proprietary Extract Blend1360 mg--
Rehmannia glutinosa Root Extract0 NP--
Poria cocos Sclerotium Extract0 NP--
Cinnamomum cassia Bark Extract0 NP--
Alisma orientale Rhizome Extract0 NP--
Dioscorea opposita Rhizome Extract0 NP--
Cornus officinalis Fruit Extract0 NP--
Paeonia suffruticosa Bark, Root Extract0 NP--
Aconitum carmichaelii Root Extract0 NP--

Other ingredients: Magnesium Silicate, Hydrated, Dextrin, China Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Economy size

Foci Pharmaceutical 1929

Formula

Jin Gui Shen Qi Wan

Scientifically authenticated herbs

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Take 8 pills 3 times daily or as directed by your health care practitioner

Precautions

Not for use during pregnancy

Keep out of reach of children

Formulation

US owned & operated since 1969. Made in China in partnership with the award winning Lanzhou Foci Pharmaceutical Co. Ltd. Plum Flower Quality Guarantee Produced at a Good Manufacturing Practices (GMP) certified factory

No pharmaceuticals or dyes Unsulfured, preservative-free herbs when available Microbial and heavy metal tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Golden Book Teapills by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Golden Book Teapills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Golden Book Teapills by Plum Flower

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container125 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1360 mg per serving

Other (inactive) ingredients: Magnesium Silicate, Hydrated, Dextrin, China Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Golden Book Teapills by Plum Flower Drug Interactions

Want to check YOUR meds against Golden Book Teapills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,451Drugs
1,451 Moderate

Ingredients driving the most interactions

Paeonia suffruticosa Bark, Root Extract 811
Cinnamomum cassia Bark Extract 442
Poria cocos Sclerotium Extract 417
Aconitum carmichaelii Root Extract 278
Rehmannia glutinosa Root Extract 258

Individual Drug Interactions

The ingredients in Golden Book Teapills interact with 1,451 drugs. Click any drug to see the details.

5 of the 8 ingredients in Golden Book Teapills interact with drugs. Each result below shows which ingredient is responsible. Paeonia suffruticosa Bark, Root Extract Cinnamomum cassia Bark Extract Poria cocos Sclerotium Extract Aconitum carmichaelii Root Extract Rehmannia glutinosa Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Golden Book Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Paeonia suffruticosa Bark, Root Extract7 drug types · 811 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining peony with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that peony might have antiplatelet, anticoagulant, and antithrombotic effects.

Likelihood Possible Evidence D
Clozapine (Clozaril)

Theoretically, peony might increase the levels and clinical effects of clozapine.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on cytochromes P450 (CYP) 1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, peony might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro and animal research shows that peony extract has estrogenic activity. Concomitant use might also increase the risk for estrogen-related adverse effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that peony suppresses the metabolism of clozapine via weak-to-moderate inhibitory effects on CYP1A2 and CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estrogen-related adverse effects.
In vitro and animal research shows that peony extract has estrogenic activity. Theoretically, peony might compete for estrogen receptors and/or cause additive estrogenic effects.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Theoretically, peony might reduce the levels and clinical effects of phenytoin.
Animal research shows that taking peony root reduces levels of phenytoin. Some researchers suggest that peony root might affect cytochrome P450 (CYP) 2C9, which metabolizes phenytoin. However, preliminary research in humans shows that peony root does not alter levels of losartan (Cozaar), which is also metabolized by CYP2C9.

Likelihood Probable Evidence D
Paeonia suffruticosa Bark, Root Extract full monograph & interactions

Cinnamomum cassia Bark Extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamomum cassia Bark Extract full monograph & interactions

Poria cocos Sclerotium Extract3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria cocos Sclerotium Extract full monograph & interactions

Aconitum carmichaelii Root Extract2 drug types · 278 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, combining aconite with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Higenamine, a constituent of aconite, is thought to have antiplatelet and antithrombotic effects. In an animal model of thrombosis, higenamine inhibited platelet aggregation and reduced the size of thrombus formation.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, combining aconite with other stimulant drugs might alter the effects of the stimulant drug or increase the risk of cardiovascular toxicity.
Aconite and its constituents have stimulant effects due to agonist activity at beta-2-adrenoreceptors. In cardiac muscle, aconite appears to have a positive inotropic effect and increases heart rate and blood pressure. However, some constituents of aconite can reduce heart rate and blood pressure.

Likelihood Possible Evidence D
Aconitum carmichaelii Root Extract full monograph & interactions

Rehmannia glutinosa Root Extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
Rehmannia glutinosa Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Golden Book Teapills, from the product label.

Plum Flower

Name
Mayway Herbs
City
Oakland
State
CA
Web Address
plumflowerherbs.com
Pharmacist Counseling Corner

Golden Book Teapills by Plum Flower: Common Questions

Does Golden Book Teapills by Plum Flower interact with any medications?
Yes. Based on its ingredients, Golden Book Teapills has a known interaction with 1,451 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Golden Book Teapills contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
No. Aconite is unsafe in pregnancy and breastfeeding due to severe toxicity risk. Rehmannia, Poria mushroom, and peony also lack enough safety data, so the facts advise against them during pregnancy and breastfeeding. Talk to your doctor or pharmacist before considering any use.
What does aconite do, and why is it in this formula?
Aconite is a traditional Chinese medicinal plant used in herbal formulas. However, it's extremely toxic—even small amounts can cause serious harm or death. The safety data we hold lists it as unsafe. If you're considering this product, discuss aconite specifically with your pharmacist.
Can I take this if I'm on blood pressure or diabetes medication?
Rehmannia and cassia cinnamon both may lower blood pressure and blood sugar further, raising the risk of hypotension or low blood sugar. You need to check with your pharmacist before starting, as dose adjustments to your medications might be necessary.
What side effects might I experience?
Peony may cause abdominal bloating, nausea, diarrhea, or loss of appetite in some people—diarrhea occurred in about 5% of patients in one trial. A rash has been reported with cassia cinnamon. Aconite can cause severe cardiovascular and neurological symptoms including irregular heartbeat, weakness, numbness, and seizures.
Does this product have evidence it actually works?
Rehmannia is possibly effective for chronic kidney disease. All the other ingredients in this formula—poria mushroom, cassia cinnamon, peony, and aconite—show insufficient reliable evidence for any condition in our data. Traditional use doesn't guarantee modern medical benefit.
What if I take a sedative or sleep medication?
Poria mushroom extract may enhance the drowsiness and side effects of sedatives and sleep aids. Talk to your pharmacist before adding this product if you take any CNS depressants.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Golden Book Teapills is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Golden Book Teapills label
Go deeper

The Full Monographs Behind Golden Book Teapills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph → Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

American Dogwood

American Dogwood is a North American flowering tree whose bark was used in traditional folk medicine, especially as a substitute for quinine to treat fevers. There is very little modern huma...

Read the full American Dogwood monograph → Herb & supplement monograph

Peony

Interacts with 811 drugs

Peony root is a traditional Chinese medicine herb often used for menstrual problems, cramps, and inflammation, frequently as part of combination formulas. Human evidence for most uses is lim...

Read the full Peony monograph → Herb & supplement monograph

Aconite

Interacts with 278 drugs

Aconite is a highly poisonous plant, and even small amounts of the raw or improperly processed root can cause severe, life-threatening reactions. There is no good scientific evidence that it...

Read the full Aconite monograph →
Sources

Sources & How We Checked

Golden Book Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

American Dogwood 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the American Dogwood monograph →

Peony 15 references
  1. Chen LC, Chou MH, Lin MF, Yang LL. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. J Clin Pharm Ther 2001;26:271-8. PubMed
  2. Guo TL, Zhou XW. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Zhong Xi Yi Jie He Za Zhi 1986;6:714-6, 707.
  3. Xie HJ, Yasar U, Sandberg M, Rane A. Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. J Clin Pharm Ther 2002;27:229-30. . PubMed
  4. Harada M, Suzuki M, Ozaki Y. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. J Pharmacobiodyn 1984;7:304-11. PubMed
  5. Anon. Monograph. Peony (Paeonia spp). Alt Med Rev 2001;6:495-9.
  6. Bruynzeel DP. Contact Dermatitis Due to Paeonia (Peony). Contact Dermatitis 1989; 20:152-3..
  7. Bian, X., Xu, Y., Zhu, L., Gao, P., Liu, X., Liu, S., Qian, M., Gai, M., Yang, J., and Wu, Y. Prevention of maternal-fetal blood group incompatibility with traditional Chinese herbal medicine. Chin Med J (Engl.) 1998;111(7):585-587.
  8. Wong, A. L. and Chan, T. Y. Interaction between warfarin and the herbal product quilinggao. Ann Pharmacother 2003;37(6):836-838.
  9. Cai Y, Yuan Q, Xu K, et al. Assessment of the therapeutic effect of total glycosides of peony for juvenile idiopathic arthritis: a systematic review and meta-analysis. Evid Based Complement Alternat Med 2016;2016:8292486.
  10. Koo YK, Kim JM, Koo JY, et al. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie 2010;65(8):624-8.
  11. Wang W, Tian DD, Zheng B, et al. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Drug Metab Dispos 2015;43(7):1147-53. PubMed
  12. Zhou Y, Jin L, Kong F, et al. Clinical and immunological consequences of total glucosides of paeony treatment in Sjögren's syndrome: A randomized controlled pilot trial. Int Immunopharmacol. 2016 Oct;39:314-319. doi: 10.1016/j.intimp.2016.08.006. PubMed
  13. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Int Urol Nephrol. 2016 Nov;48(11):1873-1880. doi: 10.1007/s11255-016-1345-5. PubMed
  14. Xu Y, Li X, Chen T, et al. Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Phytother Res. 2019;33(1):117-29. [RETRACTED].
  15. Liu X, Li X, Li X, et al. The efficacy and safety of total glucosides of peony in the treatment of primary Sjögren's syndrome: a multi-center, randomized, double-blinded, placebo-controlled clinical trial. Clin Rheumatol. 2019;38(3):657-64. Erratum i

See these in context on the Peony monograph →

Aconite 33 references
  1. Tai YT. Adverse effects from traditional Chinese medicine. Lancet 1993;341:892.
  2. Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. PubMed
  3. Fatovich DM. Aconite: a lethal Chinese herb. Ann Emerg Med 1992;21:309-11. PubMed
  4. Tomlinson B, Chan TY, Chan JC, Critchley JA. Herb-induced aconite poisoning. Lancet 1993;341:370-1. .
  5. Chan TY, Tomlinson B, Critchley JA. Aconitine poisoning following the ingestion of Chinese herbal medicines: a report of eight cases. Aust N Z J Med 1993;23:268-71. PubMed
  6. Yeih DF, Chiang FT, Huang SKS. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone. Heart 2000;84:E8. PubMed
  7. But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5.
  8. Feldkamp A, Koster B, Weber HP. [Fatal poisoning caused by aconite monk's hood]. Monatsschr Kinderheilkd 1991;139:366-7.
  9. Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. PubMed
  10. Poon WT, Lai CK, Ching CK, et al. Aconite poisoning in camouflage. Hong Kong Med J 2006;12:456-9.
  11. Guha, S., Dawn, B., Dutta, G., Chakraborty, T., and Pain, S. Bradycardia, reversible panconduction defect and syncope following self-medication with a homeopathic medicine. Cardiology 1999;91(4):268-271. PubMed
  12. Imazio, M., Belli, R., Pomari, F., Cecchi, E., Chinaglia, A., Gaschino, G., Ghisio, A., Trinchero, R., and Brusca, A. Malignant ventricular arrhythmias due to Aconitum napellus seeds. Circulation 12-5-2000;102(23):2907-2908.
  13. Telang, B. V. and Ng'ang'a, J. N. Involvement of Central adrenergic mechanisms in the induction of cardiac arrhythmias by aconitine nitrate administered intraventricularly. Indian J Physiol Pharmacol. 1975;19(1):1-10.
  14. Lin, C. C., Chou, H. L., and Lin, J. L. Acute aconitine poisoned patients with ventricular arrhythmias successfully reversed by charcoal hemoperfusion. Am J Emerg.Med 2002;20(1):66-67. PubMed
  15. Gaibazzi, N., Gelmini, G. P., Montresor, G., Canel, D., Comini, T., Fracalossi, C., Martinetti, C., Poeta, M. L., and Ziacchi, V. [Long QRS tachycardia secondary to Aconitum napellus alkaloid ingestion]. Ital.Heart J.Suppl 2002;3(8):874-877.
  16. Sorensen, B. [Poisoning with Aconitum napellus (monkshood)]. Ugeskr.Laeger 5-12-2003;165(20):2109-2110.
  17. Tai, Y. T., Lau, C. P., But, P. P., Fong, P. C., and Li, J. P. Bidirectional tachycardia induced by herbal aconite poisoning. Pacing Clin.Electrophysiol. 1992;15(5):831-839. PubMed
  18. Agarwal, B. L., Agarwal, R. K., and Misra, D. N. Malignant Arrhythmias Induced by Accidental Aconite Poisoning. Indian Heart J 1977;29(5):246-248.
  19. Dickens, P., Tai, Y. T., But, P. P., Tomlinson, B., Ng, H. K., and Yan, K. W. Fatal accidental aconitine poisoning following ingestion of Chinese herbal medicine: a report of two cases. Forensic Sci Int 6-28-1994;67(1):55-58. PubMed
  20. Chan, T. Y., Tomlinson, B., Critchley, J. A., and Cockram, C. S. Herb-induced aconitine poisoning presenting as tetraplegia. Vet.Hum.Toxicol. 1994;36(2):133-134. PubMed
  21. Chan, T. Y., Tomlinson, B., Chan, W. W., Yeung, V. T., and Tse, L. K. A case of acute aconitine poisoning caused by chuanwu and caowu. J Trop.Med Hyg. 1993;96(1):62-63.
  22. Yoshioka, N., Gonmori, K., Tagashira, A., Boonhooi, O., Hayashi, M., Saito, Y., and Mizugaki, M. A case of aconitine poisoning with analysis of aconitine alkaloids by GC/SIM. Forensic Sci.Int. 8-15-1996;81(2-3):117-123. PubMed
  23. Kimura, I., Takada, M., and Nojima, H. Aconitine induces bradycardia through a transmission pathway including the anterior hypothalamus in conscious mice. Biol.Pharm Bull. 1997;20(8):856-860. PubMed
  24. Chan TY. Aconite poisoning following the percutaneous absorption of Aconitum alkaloids. Forensic Sci Int. 2012 Nov 30;223(1-3):25-7. PubMed
  25. Chan TY. Aconitum Alkaloid Poisoning Because of Contamination of Herbs by Aconite Roots. Phytother Res. 2016 Jan;30(1):3-8.
  26. Li H, Liu L, Zhu S, Liu Q. Case reports of aconite poisoning in mainland China from 2004 to 2015: A retrospective analysis. J Forensic Leg Med. 2016 May 25;42:68-73. PubMed
  27. Zhao D, Wang J, Cui Y, Wu X. Pharmacological effects of Chinese herb aconite (fuzi) on cardiovascular system. J Tradit Chin Med. 2012 Sep;32(3):308-13. PubMed
  28. Wood C, Coulson J, Thompson J, Bonner S. An intentional aconite overdose: a case report. J Crit Care Med (Targu Mures) 2020;6(2):124-9. PubMed
  29. Bonanno G, Ippolito M, Moscarelli A, et al. Accidental poisoning with aconitum: case report and review of the literature. Clin Case Rep 2020;8(4):696-8. PubMed
  30. Blasco Mariño R, Pacheco Reyes A, Canel Micheloud C, Soteras Martínez I. Cardiac Arrest by Aconite Poisoning. Wilderness Environ Med 2021;32(3):415-417. PubMed
  31. Zhou C, Luo S, Tang J, Quick L, Liu H, Zhao Y. Poisoning Associated with Consumption of a Homemade Medicinal Liquor - Chongqing, China, 2018. MMWR Morb Mortal Wkly Rep 2022;71(16):569-573. PubMed
  32. Loo G, Yong TH, Yeo C. A case report of bidirectional ventricular tachycardia secondary to aconitum toxicity. J Arrhythm 2022;38(3):451-453. PubMed
  33. Majumder MI, Mahadi AR, Rahman OU, Roy BK, Shihab HM. Accidental poisoning with aconite overdose: A case report and resuscitative emergency management in a tertiary level hospital of Bangladesh. Clin Case Rep 2023;11(9):e7845. PubMed

See these in context on the Aconite monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team