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Dietary supplement

Gotu Kola Mandukparnee Powder Ingredients & Drug Interactions

by Herbal Hills

Gotu Kola Mandukparnee Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gotu Kola Mandukparnee Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gotu Kola Mandukparnee Powder is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for wound healing, varicose veins and poor circulation, anxiety and stress.Based on those ingredients, 579 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gotu Kola Mandukparnee powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gotu Kola Mandukparnee Powder by Herbal Hills

Ask about any prescription or over-the-counter medication and we check it for interactions with Gotu Kola Mandukparnee Powder by Herbal Hills — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gotu Kola Mandukparnee Powder by Herbal Hills

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: gotu kola mandukparnee powder. Gotu kola is a plant traditionally used in herbal medicine, and this powder form delivers it without any added inactive ingredients or fillers.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: nervine tonic supporting mental function and cognition.
  • We looked for evidence on: Cognitive function, Generalized anxiety disorder (GAD), Depression, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), stress — and 2 related terms.
  • The closest evidence on file: Gotu Kola is rated "Possibly Ineffective" for Cognitive function (Natural Medicines).
  • Also on file: Gotu Kola is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Generalized anxiety disorder (GAD), Attention deficit-hyperactivity disorder (ADHD), Depression.

The evidence for gotu kola is mixed. It's possibly effective for venous insufficiency (poor circulation in the legs) and possibly effective for burns when applied topically.

For radiation dermatitis (skin damage from radiation therapy), the evidence suggests it's probably not effective. For cognitive function and Alzheimer's disease, we don't have enough reliable evidence to say whether it works.

For generalized anxiety disorder, the evidence isn't established in the data we hold.

The evidence, ingredient by ingredient Gotu Kola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, gotu kola is generally well tolerated short-term, though quality evidence is limited. The most common side effects are gastric irritation and nausea.

There's a rare but serious concern about liver toxicity — at least four cases have been reported — though contaminants in the products tested couldn't be ruled out, and the doses used weren't documented. In one clinical trial where liver function was monitored, 120 mg daily for 6 months didn't cause changes in liver function.

The safety data advises against use during pregnancy, since there isn't enough information to be sure it's safe. During breastfeeding, safety is unknown, so it's best avoided.

If applied to skin, gotu kola can occasionally cause allergic contact dermatitis (itching, redness, and bumps), though not everyone who reacts to gotu kola products is sensitive to gotu kola itself.

Side effects, ingredient by ingredient Gotu Kola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gotu Kola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 580 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this powder, double-check any medications that affect the liver or cause drowsiness — especially sedatives, anti-anxiety drugs, and pain relievers that carry liver risk. The interaction severity is Moderate for both.

If you're on any prescription medication, use the search tool on this page to check your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gotu kola may help with poor leg circulation and wound healing, but the evidence is limited and the liver concerns — though rare — warrant caution. If you take sedatives, anti-anxiety drugs, or any medication that affects your liver, talk with your doctor or pharmacist before starting this powder.

Pregnant or breastfeeding? Skip it until you've checked with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gotu Kola Mandukparnee Powder, straight from the product label.

Brand Herbal Hills
Barcode (UPC) 8906008269253
Net contents 1 kg
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203737
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gotu Kola Mandukparnee Powder by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Not Present
Maximum serving Sizes:
3 Not Present
UPC/BARCODE
8906008269253
IngredientAmount% DV
Gotu Kola Mandukparnee powder0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Gotu Kola is considered to be a nervine tonic that supports healthy mental functions. It may act as an anti-anxiety agent. It has nootropic properties i.e. it helps support cognitive ability. May support healthy mental functions. Contains saponins which may have beneficial effect on hair, skin & connective tissues.

Halal India www.Halalindia.com S No. 001548

Suggested/Recommended/Usage/Directions

Dosage: Take 3 gms powder, 1 to 2 times a day or as advised by the physician.

Precautions

Caution: Pregnant or lactating women are advised to consume herbal products under the advice of the physician.

Keep out of reach of children.

Do not use if pouch is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place away from direct sunlight.

FDA Statement of Identity

Ayurvedic Product

General Statements

Mfg. Lic. No.: PD/AYU/002/10 (An ISO 22000:2005 Certified Company) Customer Care : 91 22 28686868 (10 a.m to 6 p.m on weekdays)

Seals/Symbols

ISO Certified Company 22000:2005 Halal India www.Halalindia.com S No. 001548 GMP Good Manufacturing Practice

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gotu Kola Mandukparnee Powder by Herbal Hills label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gotu Kola Mandukparnee Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gotu Kola Mandukparnee Powder by Herbal Hills

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Not Present Dosage formPowder Amounts shown are per serving.

Gotu Kola Mandukparnee powder

Interacts with
579 drugs
0 NP per serving

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporti...

Gotu Kola Mandukparnee powder monograph & interactions
Interaction report

Gotu Kola Mandukparnee Powder by Herbal Hills Drug Interactions

Want to check YOUR meds against Gotu Kola Mandukparnee Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
579Drugs
579 Moderate

Ingredients driving the most interactions

Gotu Kola Mandukparnee powder 579

Individual Drug Interactions

The ingredients in Gotu Kola Mandukparnee Powder interact with 579 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gotu Kola Mandukparnee Powder interact with drugs. Each result below shows which ingredient is responsible. Gotu Kola Mandukparnee powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Gotu Kola Mandukparnee Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gotu Kola Mandukparnee powder2 drug types · 579 drugs

Cns Depressants

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.
There are at least four case reports of hepatotoxicity associated with the use of gotu kola. However, more information is needed to determine if gotu kola was the causative factor in these cases.

Likelihood Possible Evidence D
Gotu Kola Mandukparnee powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gotu Kola Mandukparnee Powder, from the product label.

Herbal Hills

See all Herbal Hills products
Name
Isha Agro Developers Pvt. Ltd.
Street Address
36A/55AB, Lonavala Co.op. Indl. Est. Ltd.
City
Village - Nangargaon, Lonavala, Pune
State
Maharashtra
Phone Number
91 22 28686868
Web Address
www.herbalhills.in
Pharmacist Counseling Corner

Gotu Kola Mandukparnee Powder by Herbal Hills: Common Questions

Does Gotu Kola Mandukparnee Powder by Herbal Hills interact with any medications?
Yes. Based on its ingredients, Gotu Kola Mandukparnee Powder has a known interaction with 579 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gotu Kola Mandukparnee Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gotu kola if I'm pregnant?
The safety data advises against it — there isn't enough information to be sure it's safe during pregnancy. Talk with your doctor or pharmacist about whether this is right for you.
Is it safe while breastfeeding?
Safety during breastfeeding is unknown, so it's best avoided. Check with your doctor or pharmacist if you're considering it.
What are the side effects?
When taken by mouth, the most common side effects are stomach irritation and nausea. It's generally well tolerated short-term. Liver toxicity is rare but has been reported — if you notice signs of liver problems like jaundice or dark urine, stop and see your doctor.
Does gotu kola really help with anxiety?
We don't have enough reliable evidence to say whether it works for anxiety. The evidence we hold doesn't establish it for that purpose.
What does this powder actually do?
Gotu kola is possibly effective for venous insufficiency — poor circulation in the legs — and possibly effective for burns. For other uses like cognitive function or Alzheimer's disease, the evidence doesn't support it or is too limited to judge.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gotu Kola Mandukparnee Powder label
Go deeper

The Full Monographs Behind Gotu Kola Mandukparnee Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gotu Kola

Interacts with 579 drugs

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest poss...

Read the full Gotu Kola monograph →
Sources

Sources & How We Checked

Gotu Kola Mandukparnee Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gotu Kola 18 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.
  16. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.
  17. Bilbao, I., Aguirre, A., Zabala, R., Gonzalez, R., Raton, J., and Diaz Perez, J. L. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33(6):435-436.
  18. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed

See these in context on the Gotu Kola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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