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Dietary supplement

Gravel Root Ingredients & Drug Interactions

by Herbal Terra

Gravel Root label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gravel Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gravel Root is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for kidney stones, urinary tract complaints, fluid retention.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gravel Root by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Gravel Root by Herbal Terra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gravel Root by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a liquid extract of wildcrafted gravel root (Eupatorium purpureum) dried root. The only other ingredient is menstruum, which is the liquid used to extract the plant material and is considered inactive.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Gravel Root product and its label doesn't state a use — see Gravel Root's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We have no effectiveness ratings on file for gravel root. The evidence for what it actually does isn't established in the data we hold.

The evidence, ingredient by ingredient Gravel Root

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The safety profile of gravel root is a real concern. The main issue is its pyrrolizidine alkaloid content — compounds that can damage your liver and lungs.

With chronic use or exposure, these can cause a condition called veno-occlusive disease, which starts with vague symptoms like belly pain, vomiting, and diarrhea within days, and can lead to persistent liver enlargement within weeks. Because of limited safety data and the risk of liver toxicity, gravel root should be used cautiously and only short-term if at all.

The safety data advises against it during pregnancy and breastfeeding. If you have liver or lung problems, or you're on any liver-affecting medications, talk with your pharmacist before considering this product.

Side effects, ingredient by ingredient Gravel Root

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gravel Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 89 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking gravel root, double-check if you're on lithium (a Moderate interaction risk with raised levels possible) or drugs that induce the liver enzyme CYP3A4, including carbamazepine, phenobarbital, phenytoin, rifampin, or rifabutin (also Moderate severity, with possible increased toxic breakdown of the plant's alkaloid compounds). Use the medication checker on this page with your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gravel root carries a documented risk of liver and lung damage from its pyrrolizidine alkaloid content, especially with long-term use. It also interacts with lithium and drugs that rev up liver detoxification.

If you're taking any medications — particularly lithium or seizure drugs — check with your pharmacist first. This is one to be cautious with.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gravel Root, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7429523099064
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235063
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gravel Root by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
7429523099064
IngredientAmount% DV
wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract970 mg--

Other ingredients: Menstruum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Origin of plant material: USA.

Manufactured in the USA in an FDA registered facility

Alcohol free

Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract

Non GMO

No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free

Suggested/Recommended/Usage/Directions

Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.

FDA Disclaimer Statement

Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution May have contraindications.

Do not use if you are allergic to any ingredients.

Consult a physician before using during pregnancy, if nursing, or if you are on any medications.

Keep out of the reach of children.

Storage

Store in a cool, dry, dark place.

Formula

Eupatorium purpureum

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Made in USA Made in an FDA registered facility Natural Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gravel Root by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gravel Root label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gravel Root by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract

Interacts with
88 drugs
970 mg per serving

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scien...

Wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract monograph & interactions

Other (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gravel Root by Herbal Terra Drug Interactions

Want to check YOUR meds against Gravel Root?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
88Drugs
88 Moderate

Ingredients driving the most interactions

wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract 88

Individual Drug Interactions

The ingredients in Gravel Root interact with 88 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gravel Root interact with drugs. Each result below shows which ingredient is responsible. wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gravel Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract2 drug types · 88 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Lithium

Gravel root is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, gravel root might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
wildcrafted Gravel Root (Eupatorium purpureum) dried root liquid extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gravel Root, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra
Pharmacist Counseling Corner

Gravel Root by Herbal Terra: Common Questions

Does Gravel Root by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Gravel Root has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gravel Root contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gravel root while pregnant or breastfeeding?
No. The safety data advises against gravel root during pregnancy and breastfeeding. Talk with your doctor or pharmacist about safer alternatives if you need support during these times.
What's pyrrolizidine alkaloid and why should I care?
Pyrrolizidine alkaloids (PAs) are natural compounds in gravel root that can damage your liver and lungs. Your liver can convert them into toxic forms, especially if you're on certain medications. Long-term exposure is linked to a serious liver condition called veno-occlusive disease.
How long is it safe to use gravel root?
The data recommends cautious, short-term use only because of the liver and lung risks from its PA content. Don't use this long-term without talking to your pharmacist first.
What are the side effects of gravel root?
The main concern is liver damage and lung damage from the pyrrolizidine alkaloids it contains. With sub-acute exposure, you might notice belly pain, vomiting, diarrhea, and fluid buildup (ascites) within days, plus liver enlargement within weeks. These are serious signs — stop use and seek medical care if they occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gravel Root label
Go deeper

The Full Monographs Behind Gravel Root’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gravel Root

Interacts with 88 drugs

Gravel Root is a traditional North American herb long used by herbalists for kidney stones and urinary problems, but there is very little modern scientific evidence to support these uses. Be...

Read the full Gravel Root monograph →
Sources

Sources & How We Checked

Gravel Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gravel Root 5 references
  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Stickel F, Seitz HK. The efficacy and safety of comfrey. Public Health Nutr 2000;3:501-8. PubMed
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

See these in context on the Gravel Root monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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