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Dietary supplement

Guggul Extract 750 mg Ingredients & Drug Interactions

by NOW

Guggul Extract 750 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Guggul Extract 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Guggul Extract 750 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggul extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Guggul Extract 750 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Guggul Extract 750 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Guggul Extract 750 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: guggul extract at 750 mg per tablet. Guggul is a resin from the Commiphora tree, used traditionally to support cholesterol and weight management.

The tablet also contains inactive ingredients — cellulose, stearic acid, croscarmellose sodium, silica, magnesium stearate, and a vegetarian coating — which are fillers and binders that help form the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Guggul product and its label doesn't state a use — see Guggul's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on guggul's effectiveness is mixed and incomplete. It's rated possibly ineffective for obesity based on the data we hold.

For acne, high cholesterol, and hemorrhoids, there isn't enough reliable evidence yet to say whether it works or not. If you're considering guggul for one of these reasons, talk with your doctor about what the current science supports and whether it's the right choice for you.

The evidence, ingredient by ingredient Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guggul is generally well tolerated when taken by mouth, but digestive upset is common — belching, bloating, diarrhea, nausea, headache, and an unpleasant taste have all been reported. Skin reactions (rash, itching, swelling) are also possible and appear to be dose-dependent; the risk was higher at 2,000 mg three times daily than at 1,000 mg three times daily.

A small number of people have had hypersensitivity reactions within minutes of taking it. Rarely, a serious muscle condition called rhabdomyolysis has been reported.

Guggul should not be used during pregnancy — animal and traditional use data suggest it may stimulate the uterus and its safety is not established. There isn't enough safety information to recommend it while breastfeeding either.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Guggul.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 758 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs like warfarin or aspirin — guggul may increase bleeding risk. Also double-check if you take beta-blockers (like propranolol), calcium channel blockers (like diltiazem), birth control pills, estrogen or hormone replacement therapy, thyroid medication, tamoxifen, or any medications broken down by your liver's CYP3A4 enzyme, because guggul may reduce their effectiveness or worsen side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Guggul extract may be worth considering if you're exploring traditional remedies for cholesterol or weight, but the evidence for its effectiveness is weak and the interaction list is long. If you take any heart medications, blood thinners, birth control, hormone therapy, or thyroid drugs, you'll need to clear this with your doctor or pharmacist first.

Digestive upset and skin reactions are common, so start low and watch for any rash or itching.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Guggul Extract 750 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047663
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37512
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Guggul Extract 750 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
733739047663
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Guggul extract750 mg--

Other ingredients: Cellulose, Stearic Acid, Croscarmellose Sodium, Silica, Magnesium Stearate, Vegetarian Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: As a dietary supplement, take 1 tablet 4 times daily.

General Statements

Guggul Extract is a purified extract isolated from the crude Guggul gum of the small Commiphora mukul tree in India and has been used by traditional Ayurvedic herbalists for centuries.

Please Recycle.

TABLET SIZE

Made in the USA

HERBAL SUPPLEMENT

For more product information visit www.nowfoods.com/4766

Formula

This product is standardized for the two active components, Z-Guggulsterone and E-Guggulsterone. Other components of Guggul Extract include diterpenes, sterols, esters and fatty alcohols.

2% Guggulsterones

Precautions

Consult physician if pregnant/nursing, taking medication, or have a medical condition (especially liver, stomach, or bowel disorder).

If skin rash occurs, discontinue use.

Keep out of reach of children.

Do Not Eat Freshness Packet. Keep in Bottle.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Caution: For adults only.

Storage

Store in a cool, dry place after opening.

FDA Statement of Identity

A Dietary Supplement

Formulation

Vegetarian/Vegan

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Seals/Symbols

QUALITY GMP ASSURED

General

CODE 4766 V2

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Guggul Extract 750 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Guggul Extract 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Guggul Extract 750 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Guggul extract

Interacts with
757 drugs
750 mg per serving Form: Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul extract monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Croscarmellose Sodium, Silica, Magnesium Stearate, Vegetarian Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Guggul Extract 750 mg by NOW Drug Interactions

Want to check YOUR meds against Guggul Extract 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
757Drugs
757 Moderate

Ingredients driving the most interactions

Guggul extract 757

Individual Drug Interactions

The ingredients in Guggul Extract 750 mg interact with 757 drugs. Click any drug to see the details.

1 of the 1 ingredient in Guggul Extract 750 mg interact with drugs. Each result below shows which ingredient is responsible. Guggul extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Guggul Extract 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Guggul extract9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Guggul Extract 750 mg, from the product label.

NOW

See all NOW products
Web Address
www.nowfoods.com
Pharmacist Counseling Corner

Guggul Extract 750 mg by NOW: Common Questions

Does Guggul Extract 750 mg by NOW interact with any medications?
Yes. Based on its ingredients, Guggul Extract 750 mg has a known interaction with 757 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Guggul Extract 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does guggul actually do?
Guggul is a resin from a tree traditionally used to support cholesterol and weight management. The evidence we have shows it's possibly ineffective for obesity, and we don't have enough reliable data yet to say whether it works for acne, hemorrhoids, or high cholesterol.
Will this upset my stomach?
It might. The most common side effects are belching, bloating, diarrhea, nausea, and headache. A small number of people also report an unpleasant taste. These are generally mild, but if digestive upset is a problem for you, mention it to your pharmacist.
Can I take it if I'm pregnant or breastfeeding?
No — guggul should be avoided during pregnancy because it may stimulate the uterus and its safety in pregnancy hasn't been established. There also isn't enough safety information to recommend it while breastfeeding. Talk with your doctor if you're pregnant, planning to become pregnant, or nursing.
Are there any skin side effects?
Yes. Rash, itching, and swelling can happen, and the risk goes up with higher doses. In one study, 3% of people taking 1,000 mg three times daily had skin reactions, compared with 15% at 2,000 mg three times daily. If you develop any rash or itching, stop taking it and let your doctor know.
How many active ingredients are in this?
Just one — guggul extract at 750 mg. The rest of the tablet is made up of inactive fillers and binders like cellulose and magnesium stearate that help hold it together.
Why does this interact with so many drugs?
Guggul affects your body in multiple ways at once. It can speed up how your liver breaks down many medications, reduce how much of certain heart drugs you absorb, act like estrogen in your body, and possibly thin your blood. That's why it shows up on medication interaction lists across different drug types.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Guggul Extract 750 mg label
Go deeper

The Full Monographs Behind Guggul Extract 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Guggul Extract 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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