Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Hair Therapy Stress Relief Unflavored Ingredients & Drug Interactions

by Viviscal

Hair Therapy Stress Relief Unflavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hair Therapy Stress Relief Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hair Therapy Stress Relief Unflavored is a dietary supplement by Viviscal with 6 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 1,384 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha, Laminaria japonica. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hair Therapy Stress Relief Unflavored by Viviscal

Ask about any prescription or over-the-counter medication and we check it for interactions with Hair Therapy Stress Relief Unflavored by Viviscal — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hair Therapy Stress Relief Unflavored by Viviscal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Proprietary Seaweed Complex” is a proprietary blend — the label gives one combined amount (25 mg) without saying how much of each component you get.

Hair Therapy Stress Relief contains 6 active ingredients designed to support hair and manage stress. Biotin is a B vitamin that plays a role in hair health.

Ashwagandha is an herbal adaptogen traditionally used to help manage stress and promote relaxation. Marine collagen provides amino acids that support hair structure.

Dunaliella salina is a type of algae, and Laminaria japonica (a seaweed) are included for their nutrient profiles. Haematococcus pluvialis is a microalgae source of astaxanthin.

The powder also contains inactive ingredients like sugar, natural flavors, and maltodextrin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: hair health and restful sleep.
  • We looked for evidence on: Androgenic alopecia, Alopecia areata, Brittle nails, Insomnia, Stress, Anxiety — and 4 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Insomnia, Stress.
  • Also on file: Biotin is rated "Insufficient Reliable Evidence To Rate" for Alopecia areata, Brittle nails.

Biotin is likely effective for biotin deficiency, though it's possibly ineffective for multiple sclerosis and seborrheic dermatitis, and evidence for alopecia areata is insufficient. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder — the main reasons people take this product — though evidence for bipolar disorder is insufficient.

The facts don't establish evidence for marine collagen, Dunaliella salina, Laminaria japonica, or Haematococcus pluvialis in our data.

The evidence, ingredient by ingredient Biotin Ashwagandha Laminaria

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at fairly high doses, because your body removes excess through urine. Rare reports associate very high doses with mild diarrhea, and one case reported a serious reaction in someone taking multiple supplements together — causality wasn't clear.

Check with your doctor before taking high-dose biotin supplements. Ashwagandha is generally well tolerated short-term in healthy adults, though long-term safety data are limited.

The most common side effects are diarrhea, nausea, and vomiting, but these don't typically occur at usual doses. Rare serious concerns include liver damage, low thyroid function that reversed after stopping, and one case of intracranial bleeding linked to possible vasospasm — though ashwagandha's exact role in that case was unclear.

Laminaria can concentrate arsenic from seawater; one case reported arsenic poisoning symptoms after months of use. Iodine content varies and may affect the thyroid.

Side effects, ingredient by ingredient Biotin Ashwagandha Laminaria

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Laminaria, Ashwagandha.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,385 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications against these types: blood pressure drugs (ACE inhibitors, potassium-sparing diuretics, and other antihypertensives), thyroid medications (thyroid hormone and antithyroid drugs), sedatives and CNS depressants (including benzodiazepines), diabetes medications, immunosuppressants, amiodarone, digoxin, and hepatotoxic drugs. These carry Moderate severity interactions with ashwagandha or laminaria.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people looking to support hair health and manage everyday stress. If you take any blood pressure meds, diabetes drugs, thyroid medications, sedatives, benzodiazepines, or immunosuppressants, check with your pharmacist first — ashwagandha and the seaweed ingredient have documented interactions with these.

Don't take it if you're pregnant or breastfeeding without talking to your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hair Therapy Stress Relief Unflavored, straight from the product label.

Brand Viviscal
Barcode (UPC) 022600300052
Net contents 30 Powder Packet(s); 2.4 Ounce(s); 68 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 246401
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hair Therapy Stress Relief Unflavored by Viviscal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.08 oz
Maximum serving Sizes:
0.08 oz
Servings per container
30
UPC/BARCODE
022600300052
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Biotin5000 mcg16667%
Added Sugars1 Gram(s)2%
Total Sugars1 Gram(s)--
Ashwagandha125 mg--
Marine Collagen500 mg--
Dunaliella salina0 NP--
Proprietary Seaweed Complex25 mg--
Laminaria japonica0 NP--
Haematococcus pluvialis0 NP--

Other ingredients: Sugar, Natural Flavors, Maltodextrin, Less than 2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

At Viviscal, we understand hair. For over 25 years, through our intensive research and multiple clinical studies on our core supplement, we have helped women successfully reclaim their hair health.

Proud Supporter of Arbor Day Foundation Paper box Multi-layer packet How2Recycle.info

Formulation

Now, our Viviscal hair therapy provides a balance of nutrients to help address your specific needs and help form the foundation for healthy, gorgeous hair.

Viviscal hair therapy beauty rest promotes restful sleep and boosts hair health, fortifying your hair's natural beauty.

Soy & Dairy Free Gluten Free No Artificial Dyes or Flavors

Boost hair health + support sleep

Made in USA with U.S. and imported ingredients.

Formula

Our seaweed complex is a proprietary blend of carefully-selected nutrient-rich sea kelp & algae. Biotin is an essential nutrient that supports hair health. Marine collagen contains amino acids which support keratin formation, the main building block of hair. Melatonin is a naturally occurring hormone that helps regulate your body's circadian rhythm to promote a healthy sleep cycle.

Seaweed Complex & Biotin - Melatonin - Marine Collagen

Suggested/Recommended/Usage/Directions

Directions: Enjoy a fully personalized experience that fits your diet and lifestyle. 1 Choose any 8-12 oz beverage of choice, 30-60 minutes prior to bedtime. 2 Pour entire packet into cup 3 Stir until dissolved. Enjoy, and sleep well!

Suggested Use: As a dietary supplement, adults add 1 packet to 8-12 oz of liquid 30-60 minutes prior to sleep event.

Precautions

Do not exceed 1 packet per day.

Warning: Melatonin may cause drowsiness or sleepiness, do not take when driving, operating heavy machinery, or engaging in any activity that requires alertness. This product is not intended to treat insomnia or other sleep disorders.

If you have a medical condition, are on medication, are pregnant or nursing or have questions regarding you nutritional need, consult a qualified healthcare professional before using this product.

Not to be used by children under 18 years old. Keep out of reach of children.

Contains: Fish (Tilapia)

Storage

Store in a cool dry place.

Store in a cool dry place.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hair Therapy Stress Relief Unflavored by Viviscal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hair Therapy Stress Relief Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hair Therapy Stress Relief Unflavored by Viviscal

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.08 oz Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
5000 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Ashwagandha

Interacts with
1,372 drugs
125 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Ashwagandha monograph & interactions

Marine Collagen

500 mg per serving

Proprietary Seaweed Complex

25 mg per serving

Other (inactive) ingredients: Sugar, Natural Flavors, Maltodextrin, Less than 2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hair Therapy Stress Relief Unflavored by Viviscal Drug Interactions

Want to check YOUR meds against Hair Therapy Stress Relief Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,384Drugs
930 Moderate 454 Minor

Ingredients driving the most interactions

Ashwagandha 1,372
Laminaria japonica 69

Individual Drug Interactions

The ingredients in Hair Therapy Stress Relief Unflavored interact with 1,384 drugs. Click any drug to see the details.

2 of the 6 ingredients in Hair Therapy Stress Relief Unflavored interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha Laminaria japonica

Each ingredient & the kinds of drugs it affects

For each ingredient in Hair Therapy Stress Relief Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha full monograph & interactions

Laminaria japonica6 drug types · 69 drugs

Ace Inhibitors (Aceis)

Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.
Laminaria contains potassium.

Likelihood Possible Evidence D
Amiodarone (Cordarone)

Theoretically, combining laminaria with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with laminaria supplements, some of which may contain as much as 1000 mcg iodine, might increase the risk of adverse effects from iodine, including altered thyroid function.

Likelihood Possible Evidence D
Antithyroid Drugs

Due to its iodine content, laminaria might alter the effects of antithyroid drugs.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of antithyroid drugs.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, laminaria might increase the risk of hyperkalemia, which could increase the effects and adverse effects of digoxin.
Laminaria contains potassium.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, laminaria might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Laminaria contains potassium.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, laminaria might alter the effects of thyroid hormone.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Laminaria japonica full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hair Therapy Stress Relief Unflavored, from the product label.

Viviscal

See all Viviscal products
Name
Church & Dwight Co., Inc.
City
Ewing
State
NJ
ZipCode
08628
Phone Number
1-866-951-1748
Web Address
www.viviscal.com
Pharmacist Counseling Corner

Hair Therapy Stress Relief Unflavored by Viviscal: Common Questions

Does Hair Therapy Stress Relief Unflavored by Viviscal interact with any medications?
Yes. Based on its ingredients, Hair Therapy Stress Relief Unflavored has a known interaction with 1,384 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hair Therapy Stress Relief Unflavored contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or trying to get pregnant?
Ashwagandha is traditionally thought to risk miscarriage, so the safety data advise against it during pregnancy. Laminaria contains high amounts of iodine, which can harm a developing baby's thyroid, so kelp supplements are best avoided unless your doctor directs otherwise. Biotin is likely safe in amounts from food and prenatal vitamins. Talk with your doctor or pharmacist about whether this product is right for you.
Can I take this while breastfeeding?
There isn't enough safety information for ashwagandha while breastfeeding, so it's best avoided. Laminaria's iodine passes into breast milk and high amounts may affect your baby's thyroid, so avoid concentrated supplements. Talk with your doctor or pharmacist for personalized advice.
Will this actually help my hair?
Biotin is likely effective for biotin deficiency. For the other ingredients — marine collagen, seaweeds, and the algae sources — we don't hold evidence in our data. Ashwagandha is possibly effective for stress and anxiety, which is what this product targets, but we don't have evidence that it directly improves hair.
What are the most common side effects?
Ashwagandha may cause diarrhea, nausea, and vomiting, though these don't commonly happen at typical doses. Biotin at very high doses has rarely been linked to mild diarrhea. Laminaria can concentrate arsenic from seawater, and iodine content varies, which may affect your thyroid.
Is biotin safe at high doses?
Biotin is generally well tolerated because excess is removed in your urine. That said, check with your doctor before taking high-dose biotin supplements, especially if you're already getting it from other sources.
What is ashwagandha used for?
Ashwagandha is an herbal adaptogen possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder — it's included here because it may help with stress relief. It's generally well tolerated short-term, though long-term safety data are limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hair Therapy Stress Relief Unflavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hair Therapy Stress Relief Unflavored label
Go deeper

The Full Monographs Behind Hair Therapy Stress Relief Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Laminaria

Interacts with 69 drugs

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because its iodine content can be high and variabl...

Read the full Laminaria monograph →
Sources

Sources & How We Checked

Hair Therapy Stress Relief Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
  17. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med 2021;1 PubMed
  18. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J R Coll Physicians Edinb. 2021;51(4):363-365. PubMed
  19. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Cureus. 2022 Mar 25;14(3):e23494. PubMed
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See these in context on the Ashwagandha monograph →

Laminaria 9 references
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See these in context on the Laminaria monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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