Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

HCL Breakthrough Ingredients & Drug Interactions

by BiOptimizers

HCL Breakthrough label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HCL Breakthrough against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

HCL Breakthrough is a dietary supplement by BiOptimizers with 7 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HCL Breakthrough by BiOptimizers

Ask about any prescription or over-the-counter medication and we check it for interactions with HCL Breakthrough by BiOptimizers — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HCL Breakthrough by BiOptimizers

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 7 active ingredients.
  • “Enzyme Blend” is a proprietary blend — the label gives one combined amount (21.50 mg) without saying how much of each component you get.

HCL Breakthrough contains seven active ingredients: amylase, lipase, cellulase, betaine hydrochloride, an enzyme blend, protease 4.5, and protease 3. These are digestive enzymes designed to help break down food.

The product also contains inactive ingredients (rice extract, cellulose, and water) as fillers and capsule material. Betaine hydrochloride is included to increase stomach acidity.

The proteases and other enzymes work to digest proteins, carbohydrates, and fats.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: increase stomach acid to support digestion.
  • We looked for evidence on: Dyspepsia, hypochlorhydria, indigestion, low stomach acid.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The data we hold doesn't establish effectiveness for any of the conditions these ingredients are used for. Lipase, betaine hydrochloride, and the proteases all have insufficient evidence to rate their use in conditions like indigestion (dyspepsia), inflammatory bowel disease, or diarrhea.

That doesn't mean they don't work—it means the research we have access to isn't strong enough to say either way. Your results may depend on your individual digestion and the specific reason you're taking it.

The evidence, ingredient by ingredient Betaine Hydrochloride Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated, though people with serious digestive conditions should use it only under medical guidance. The proteases are also generally well tolerated for most adults but may cause digestive upset or allergic reactions in some people.

Betaine hydrochloride, however, can irritate the stomach and is not safe for people with ulcers, gastritis, or acid reflux—it can cause heartburn and may slow ulcer healing. For pregnancy: betaine hydrochloride should be avoided, as there isn't enough safety information.

Lipase and the proteases also lack adequate safety data during pregnancy—if you're pregnant or planning to be, talk with your doctor or pharmacist before using this product. Safety during breastfeeding has not been well studied for any of these ingredients; check with your healthcare provider first.

Side effects, ingredient by ingredient Betaine Hydrochloride Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking HCL Breakthrough, double-check if you use H2-blockers, antacids, or proton pump inhibitors (PPIs) for heartburn or acid reflux—the betaine hydrochloride in this product may reduce how well they work. We could not check three ingredients, so if you're on other medications, use the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

HCL Breakthrough is an enzyme product aimed at digestive support, but its effectiveness isn't established in the data we hold. The main caution is betaine hydrochloride, which can interfere with acid-reducing medications like H2-blockers, antacids, and PPIs.

If you take any of those, or have ulcers or acid reflux, talk with your pharmacist before starting. Pregnant or breastfeeding?

Check with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HCL Breakthrough, straight from the product label.

Brand BiOptimizers
Barcode (UPC) 0648620408426
Net contents 90 Veggie Cap(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 320984
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HCL Breakthrough by BiOptimizers, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
0648620408426
IngredientAmount% DV
Amylase0 NP--
Lipase0 NP--
Cellulase0 NP--
Betaine Hydrochloride500 mg--
Enzyme Blend21.5 mg--
Protease 4.50 NP--
Protease 30 NP--
Trace Mineral5 mg--

Other ingredients: Rice extract, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

HCL Breakthrough is a natural source of beet-derived hydrochloric acid, that may help increase stomach acid, or hydrochloric acid to support digestion and detoxification.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule with each meal, or within 30 minutes of eating a meal.

Storage

Store in a cool/dry location.

Precautions

Caution: Keep out of reach of children.

Do not use if ulcer or gastritis are present. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition.

General Statements

To reorder or contact us, please visit: BiOptimizers.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Optimized digestive solutions

Vegan

Gluten-free Soy-free

Natural digestive support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HCL Breakthrough by BiOptimizers label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HCL Breakthrough label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HCL Breakthrough by BiOptimizers

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
500 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Enzyme Blend

21.5 mg per serving

Trace Mineral

5 mg per serving

Other (inactive) ingredients: Rice extract, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

HCL Breakthrough by BiOptimizers Drug Interactions

Want to check YOUR meds against HCL Breakthrough?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in HCL Breakthrough interact with 36 drugs. Click any drug to see the details.

1 of the 7 ingredients in HCL Breakthrough interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in HCL Breakthrough with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HCL Breakthrough, from the product label.

BiOptimizers

See all BiOptimizers products
Name
BiOptimizers USA, Inc.
Street Address
5470 Kietzke Lane, Suite 300
City
Reno
State
NV
ZipCode
89511
Web Address
BiOptimizers.com
Pharmacist Counseling Corner

HCL Breakthrough by BiOptimizers: Common Questions

Does HCL Breakthrough by BiOptimizers interact with any medications?
Yes. Based on its ingredients, HCL Breakthrough has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HCL Breakthrough contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an H2-blocker or PPI for acid reflux?
Not without talking to your pharmacist first. Betaine hydrochloride in this product increases stomach acid, which could make your H2-blocker or PPI less effective. Your pharmacist can help you figure out timing or whether this product is right for you.
Is this safe if I have an ulcer?
No. Betaine hydrochloride can irritate ulcers and may slow healing. Skip this product if you have ulcers, gastritis, or true acid reflux.
Can I take this while pregnant?
Not without your doctor's go-ahead. Betaine hydrochloride should be avoided in pregnancy. Lipase and the proteases also lack enough safety data, so talk with your doctor or pharmacist for personalized advice.
What does betaine hydrochloride do in this product?
It increases stomach acid to help your digestive enzymes work better. But that's exactly why it can interfere with acid-reducing medications.
Can I take this if I'm breastfeeding?
Safety hasn't been well studied for any of these ingredients during breastfeeding. Check with your healthcare provider first before using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HCL Breakthrough is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HCL Breakthrough label
Go deeper

The Full Monographs Behind HCL Breakthrough’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

HCL Breakthrough's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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