Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Heart Blu Ingredients & Drug Interactions

by BluScience

Heart Blu label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Heart Blu against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Heart Blu is a dietary supplement by BluScience with 3 active ingredients. Its ingredients are commonly taken for antioxidant support, heart health, brain and memory health.Based on those ingredients, 88 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Blueberry fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Heart Blu by BluScience

Ask about any prescription or over-the-counter medication and we check it for interactions with Heart Blu by BluScience — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Heart Blu by BluScience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Heart Blu contains three active ingredients. Blueberry fruit extract is the one we have detailed information about.

The product also includes phytosterols and pterostilbene, plus several inactive ingredients (hypromellose, talc, silica, magnesium stearate, microcrystalline cellulose, mica-based pearlescent pigment, titanium dioxide, and FD&C Blue #1 and FD&C Red #40) that serve as capsule material, binders, and colorants.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Blueberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy cholesterol levels within normal range.
  • We looked for evidence on: Hyperlipidemia, Hypertriglyceridemia, Cardiovascular disease (CVD), Metabolic syndrome, Dyslipidemia, Cholesterol management.
  • The closest evidence on file: Blueberry is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Blueberry is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertriglyceridemia, Metabolic syndrome.

Blueberry fruit extract has been studied for several cardiovascular and cognitive claims. The evidence rates it as possibly ineffective for high blood pressure.

For age-related cognitive decline, anxiety, athletic performance, high cholesterol (hyperlipidemia), and cardiovascular disease, the evidence is insufficient to rate whether it works. We hold no effectiveness data for phytosterols or pterostilbene.

The evidence, ingredient by ingredient Blueberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Blueberry is generally well tolerated. The most common side effects reported with freeze-dried blueberries are constipation, diarrhea, nausea, and vomiting — in one trial, about a quarter of people taking 50 grams daily dropped out in the first week due to stomach complaints.

Eating fresh blueberries is considered safe, but concentrated supplements in pregnancy and breastfeeding haven't been well studied; there isn't enough data to know whether high-dose extracts are safe during these times. Talk with your pharmacist or doctor for personalized guidance if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Blueberry

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Blueberry.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 88 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Heart Blu, double-check with your pharmacist or doctor if you take antidiabetes drugs (minor interaction risk with blueberry extract), flurbiprofen or similar NSAIDs (minor interaction risk), or buspirone (minor interaction risk). No interactions are documented for the other ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Heart Blu is mainly a concern if you take diabetes medications or pain relievers like flurbiprofen, since blueberry extract may affect how your body handles them. If you're thinking about adding this product and you take any medications regularly, run them through the checker on this page first.

A quick conversation with your pharmacist can help you avoid any interactions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Heart Blu, straight from the product label.

Brand BluScience
Net contents 60 Vegetarian Capsules
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1591
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Heart Blu by BluScience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
IngredientAmount% DV
Phytosterols400 mg--
Blueberry fruit extract100 mg--
Pterostilbene50 mg--

Other ingredients: Hypromellose, Talc, Silica, Magnesium Stearate, Microcrystalline Cellulose, mica-based pearlescent pigment and titanium dioxide, FD&C Blue #1, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BluScience(TM) is the fusion of blueberries and science…an extraordinary combination made possible by pterostilbene (pTeroPure(R)), a compound found naturally in blueberries. BluScience(TM) has created a line of products that combines the powerful effects of this protective agent with other ingredients that have potent health benefits. BluScience(TM) is committed to providing the most beneficial and highest quality formulations specially designed to support optimum health.* Our BluScience line of product include: HeartBlu Healthy Heart Support* Trim Blu Weight Management* EternalBlu Anti-aging Support* Blu2Go Focus & Energy Melt*

From the creators of pTeroPure(R)

HeartBlu Healthy Heart Support contains pTer0Pure(R) Pteroslilbene, a pure form of the all—trans pterostilbene found naturally in blueberries. Harnessing the science behind blueberries and the superior cellular uptake of pterostilbene, HeartBlu functions as a cardiovascular supplement by helping to maintain healthy cholesterol levels.*

pTeroPure(R) a trademark of ChromaDex, Inc. www.pteropure.com

pTeroPure(R) Pterostilbene: Supports healthy cholesterol levels already within the normal range.* Ingredients that complement pterostilbene: Phytosterols: Phytosterols are the plant's version of cholesterol, used to support the cell membrane. They may work to help regulate cholesterol's absorption by the body because of their similar chemical structure.* Blueberry Fruit Extract: The other polyphenols in blueberry extract naturally complement pterostilbenes benefitial eftects.*

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medications or have a medical condition.

General Statements

For more information:

Healthy Heart Support*

Made in USA

One capsule provides the amount of pterostilbene found in over 500 cartons of blueberries* Helps maintain healthy cholesterol levels* Supporta cardiovascular health*

The fusion of blueberries and science

US patents pending

General

V0711

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take (2) capsules daily - one in the morning and one in the evening. Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Heart Blu by BluScience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Heart Blu label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Heart Blu by BluScience

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phytosterols

400 mg per serving

Blueberry fruit extract

Interacts with
88 drugs
100 mg per serving

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...

Blueberry fruit extract monograph & interactions

Pterostilbene

50 mg per serving

Other (inactive) ingredients: Hypromellose, Talc, Silica, Magnesium Stearate, Microcrystalline Cellulose, Mica-based pearlescent pigment and titanium dioxide, FD&C Blue #1, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Heart Blu by BluScience Drug Interactions

Want to check YOUR meds against Heart Blu?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
88Drugs
88 Minor

Ingredients driving the most interactions

Blueberry fruit extract 88

Individual Drug Interactions

The ingredients in Heart Blu interact with 88 drugs. Click any drug to see the details.

1 of the 3 ingredients in Heart Blu interact with drugs. Each result below shows which ingredient is responsible. Blueberry fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Heart Blu with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blueberry fruit extract3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D
Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B
Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B
Blueberry fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Heart Blu, from the product label.

BluScience

See all BluScience products
Name
BluScience
City
Irvine
State
CA
ZipCode
92618
Phone Number
1.855.777.0660
Web Address
www.bluscience.com
Pharmacist Counseling Corner

Heart Blu by BluScience: Common Questions

Does Heart Blu by BluScience interact with any medications?
Yes. Based on its ingredients, Heart Blu has a known interaction with 88 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Heart Blu contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Heart Blu lower my blood sugar if I take diabetes medication?
Blueberry extract in the product may theoretically lower blood sugar, which could increase the risk of low blood sugar if combined with diabetes drugs. This is a minor interaction, but you should talk with your pharmacist or doctor before adding Heart Blu to your regimen.
What are the most common side effects of blueberry extract in this product?
Freeze-dried blueberries can cause constipation, diarrhea, nausea, and vomiting. In one clinical trial, about 26% of people taking 50 grams daily stopped because of stomach upset in the first week. Most people tolerate blueberry well, though.
Is Heart Blu safe to take while I'm pregnant or breastfeeding?
There isn't enough data to know whether high-dose blueberry extracts are safe during pregnancy or breastfeeding. Eating blueberries as food is fine, but concentrated supplements haven't been well studied. Talk with your doctor or pharmacist for personalized advice.
Does blueberry extract in this product really help with high blood pressure?
The evidence rates blueberry as possibly ineffective for high blood pressure. For other heart-health claims like cholesterol or cardiovascular disease prevention, there's not enough reliable evidence to rate whether it works.
What are phytosterols and pterostilbene in this product for?
The product contains phytosterols and pterostilbene as active ingredients, but we hold no interaction data or effectiveness information for either one. Your pharmacist can tell you more about their intended roles in heart health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Heart Blu is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Heart Blu label
Go deeper

The Full Monographs Behind Heart Blu’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph →
Sources

Sources & How We Checked

Heart Blu's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Blueberry 7 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
  3. Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
  4. Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
  5. Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
  6. Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
  7. Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed

See these in context on the Blueberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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