Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Hemo Rage Black Ultra Concentrate Apple Ambush Ingredients & Drug Interactions

by Nutrex Research

Hemo Rage Black Ultra Concentrate Apple Ambush label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemo Rage Black Ultra Concentrate Apple Ambush against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Hemo Rage Black Ultra Concentrate Apple Ambush is a dietary supplement by Nutrex Research with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,006 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Caffeine Anhydrous, L-Arginine Alpha Ketoglutarate, Methylhexaneamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Beyond Extreme Energy Boosting Turbo Shot” is listed as a grouped ingredient — the label gives one combined amount (2,180 mg) without saying how much of each component you get.

Hemo Rage Black Ultra Concentrate has seven active ingredients. Sodium and taurine are amino acid and electrolyte support; caffeine anhydrous is a central nervous system stimulant for energy and alertness.

L-arginine alpha ketoglutarate is an amino acid meant to support circulation and nitric oxide production. Huperzine A is an alkaloid compound used for cognitive function.

CarnoSyn (beta-alanine) is an amino acid linked to athletic endurance. The product also contains a proprietary blend called "Beyond Extreme Energy Boosting Turbo Shot," which includes methylhexaneamine (1,3-DMAA), a potent synthetic stimulant.

Inactive ingredients include water, phosphoric acid, citric acid, natural flavors, sucralose, sodium citrate, sodium benzoate, potassium sorbate, acesulfame potassium, FD&C Yellow 5, and FD&C Blue 1.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Neonatal apnea — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Postoperative headache — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Athletic performance — rated "Likely Effective" (Caffeine) (Natural Medicines).
  • On file: Cystic fibrosis — rated "Likely Effective" (Sodium) (Natural Medicines).
  • On file: Mental alertness — rated "Likely Effective" (Caffeine) (Natural Medicines).

Sodium is likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity, but there isn't enough reliable evidence for bipolar disorder or congestive heart failure. Taurine is possibly effective for hepatitis and congestive heart failure, but possibly ineffective for obesity.

Caffeine is effective for neonatal apnea and postoperative headache, likely effective for mental alertness and athletic performance, and possibly effective for bronchopulmonary dysplasia. Huperzine A is possibly effective for Alzheimer disease but has insufficient evidence for athletic performance, cognitive impairment, vascular dementia, depression, and memory.

CarnoSyn (beta-alanine) is possibly effective for athletic performance and physical performance, but there isn't enough evidence for age-related cognitive decline, COPD, cognitive function, or menopausal symptoms. L-arginine and methylhexaneamine have no established effectiveness ratings in our data.

The evidence, ingredient by ingredient Sodium Taurine Caffeine L-arginine Huperzine A Beta-alanine 1,3-dmaa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated in normal dietary amounts but should not be supplemented without medical advice; high intake is tied to high blood pressure, heart strain, and kidney disease. Taurine is generally well tolerated short-term in healthy adults but long-term safety is uncertain; most common side effects are constipation, diarrhea, and indigestion, though hypersensitivity reactions occur rarely.

Caffeine in moderate doses is typically well tolerated but can cause anxiety, insomnia, tremors, nausea, and restlessness; it's associated with pregnancy risks. L-arginine is generally well tolerated short-term but can lower blood pressure and safety for self-treatment is not well established; common side effects include abdominal pain, bloating, nausea, diarrhea, and headache.

Huperzine A is pharmacologically active and can cause dose-dependent cholinergic side effects like blurred vision, constipation, diarrhea, dizziness, dry mouth, nausea, and vomiting. CarnoSyn is generally well tolerated but commonly causes harmless skin tingling and flushing.

Methylhexaneamine (1,3-DMAA) is banned in many countries and tied to serious cardiovascular harm including heart attack, stroke, cardiac arrest, and life-threatening lactic acidosis; it's also linked to anxiety, paranoia, and suicidal behavior.

Side effects, ingredient by ingredient Sodium Taurine Caffeine L-arginine Huperzine A Beta-alanine 1,3-dmaa

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Huperzine A, L-arginine, Caffeine, Taurine, 1,3-dmaa, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,006 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antihypertensive drugs (blood pressure medications), ACE inhibitors, or ARBs, talk with your doctor or pharmacist first — this product may lower your blood pressure too far. If you take lithium for bipolar disorder, ephedrine, stimulant drugs, anticholinergic drugs, cholinergic drugs, blood thinners, diabetes medications, potassium-sparing diuretics, or sildenafil, check with your pharmacist before starting.

The methylhexaneamine in this product is a potent stimulant banned in many countries; anyone with a heart condition, high blood pressure, or anxiety should avoid it entirely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant pre-workout drink built on caffeine, taurine, and methylhexaneamine — ingredients designed to boost energy and athletic performance. If you take any blood pressure medication, diabetes drug, blood thinner, lithium, or any other regular medication, you need to talk with your doctor or pharmacist before using this product, because the risk of serious interactions is real.

The methylhexaneamine and caffeine combination alone carries a Major severity risk with ephedrine, and high sodium content is a concern if your doctor has advised you to limit salt intake.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemo Rage Black Ultra Concentrate Apple Ambush, straight from the product label.

Brand Nutrex Research
Barcode (UPC) 853237000554
Net contents 4 fl. Oz.; 118.3 mL
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 9855
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 fl. Oz.
Maximum serving Sizes:
4 fl. Oz.
Servings per container
2
UPC/BARCODE
853237000554
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 g1%
Sodium35 mg1%
Taurine0 NP--
Caffeine Anhydrous0 NP--
L-Arginine Alpha Ketoglutarate0 NP--
Huperzine A0 NP--
CarnoSyn0 NP--
Beyond Extreme Energy Boosting Turbo Shot2180 mg--
Methylhexaneamine0 NP--

Other ingredients: Water, phosphoric acid, Citric Acid, Natural flavors, Sucralose, Sodium Citrate, Sodium Benzoate, Potassium Sorbate, Acesulfame Potassium, FD&C Yellow 5, FD&C Blue 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store out of sunlight in a cool, dry place.

Precautions

This product contains ingredients that may be banned by some sports organizations. Do not use if cap safety seal is broken.

KEEP OUT OF REACH OF CHILDREN.

Allergen Warning: Manufactured on equipment that processes products containing milk, egg, soybeans, shellfish, wheat and tree nuts.

WARNING: NOT TO BE USED BY ANYONE UNDER THE AGE OF 18.

Do not use if pregnant or nursing.

Do not use this product for longer than 8 weeks and make sure that usage is followed by a 2-week off-period. Consult your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, anti-depressants, aspirin, non-steroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, phenylethylamine or other stimulants. Consult your physician prior to use if you have a medical condition, including but not limited to heart, liver, kidney or thyroid disease, psychiatric disorders, difficulty urinating, diabetes, high blood pressure, pernicious anemia, cardiac arrhythmia, hyper beta-alaninemia, recurrent headaches, enlarged prostate or glaucoma. May cause flushing and itching. Discontinue use 2 weeks prior to surgery. Immediately discontinue if you experience rapid heartbeat, dizziness, severe headaches or shortness of breath.

FDA Disclaimer Statement

The statements on this label have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

As individuals vary so may results from using this product.

Use your smart phone to scan this QR code and see real consumer reviews about this product. (QR Code)

2 SERVINGS

TURBO ENERGY SHOT

NATURALLY & ARTIFICIALLY FLAVORED

one serving

EXTREME CAUTION ADVISED: HEMO-RAGE BLACK TURBO SHOT MAY BE STRONGER THAN ANY ENERGY-BOOSTING PRODUCT YOU HAVE EVER TRIED. IT MAY BE WAY TOO STRONG FOR SOME INDIVIDUALS. HEMO-RAGE BLACK TURBO SHOT IS SO POWERFUL THAT ALL YOU NEED IS ONE SINGLE SERVING. JUST HALF THIS BOTTLE AND YOU’RE SET FOR AN EXPERIENCE UNLIKE ANYTHING ELSE!

Never exceed the recommended maximum dosage. Do not consume synephrine, caffeine or thyroid-boosting compounds from other sources, including but not limited to coffee, tea, soda and other dietary supplements or medications containing phenylephrine, caffeine or any stimulants whatsoever.

General

LBL-RAGESHOT-4OZ-AA-V1-US

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: HEMO-RAGE Black Turbo Shot may be way too strong for some individuals. Start by taking only one serving (half this bottle) in a 24-hour period. Once you’ve tested your tolerance you may dare to consume a full bottle. NEVER EXCEED ONE FULL BOTTLE IN A 24-HOUR PERIOD!

Brand IP Statement(s)

Natural Alternatives International (NAI) is the owner of patents 5,965,596, 6,172,098, 6,426,361, 6,680,294 and registered trademark CarnoSyn.®

Formula

This product contains caffeine.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemo Rage Black Ultra Concentrate Apple Ambush label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 fl. Oz. Dosage formLiquid Servings per container2 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
35 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Beyond Extreme Energy Boosting Turbo Shot

2180 mg per serving

Other (inactive) ingredients: Water, Phosphoric acid, Citric Acid, Natural flavors, Sucralose, Sodium Citrate, Sodium Benzoate, Potassium Sorbate, Acesulfame Potassium, FD&C Yellow 5, FD&C Blue 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research Drug Interactions

Want to check YOUR meds against Hemo Rage Black Ultra Concentrate Apple Ambush?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,006Drugs
8 Major 933 Moderate 65 Minor

Ingredients driving the most interactions

Caffeine Anhydrous 655
L-Arginine Alpha Ketoglutarate 403
Methylhexaneamine 321
Huperzine A 219
Sodium 205

Individual Drug Interactions

The ingredients in Hemo Rage Black Ultra Concentrate Apple Ambush interact with 1,006 drugs. Click any drug to see the details.

6 of the 7 ingredients in Hemo Rage Black Ultra Concentrate Apple Ambush interact with drugs. Each result below shows which ingredient is responsible. Caffeine Anhydrous L-Arginine Alpha Ketoglutarate Methylhexaneamine Huperzine A Sodium Taurine

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemo Rage Black Ultra Concentrate Apple Ambush with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

L-Arginine Alpha Ketoglutarate9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Alpha Ketoglutarate full monograph & interactions

Methylhexaneamine2 drug types · 321 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro. Theoretically, 1,3-DMAA can increase levels of CYP2D6 substrates. Some of drugs that are CYP2D6 substrates include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.

Likelihood Possible Evidence D
Stimulant Drugs

1,3-DMAA is thought to have stimulant effects. There is concern that taking 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some preliminary research shows that taking 1,3-DMAA 50 mg daily in combination with caffeine 250 mg daily does not increase respiratory rate, blood pressure, or other cardiovascular outcomes compared to taking caffeine alone in healthy men. However, a number of cardiovascular side effects have been reported for patients taking 1,3-DMAA in combination with other stimulants including caffeine. Theoretically, combining 1,3-DMAA with stimulant drugs might increase the risk of adverse cardiovascular effects. Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Likelihood Possible Evidence D
Methylhexaneamine full monograph & interactions

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Taurine2 drug types · 173 drugs

Antihypertensive Drugs

Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Some clinical evidence suggests that taurine can reduce both systolic and diastolic blood pressure.

Likelihood Probable Evidence D
Lithium

Theoretically, taurine might reduce excretion and increase plasma levels of lithium.
Taurine is thought to have diuretic properties, which might reduce the excretion of lithium.

Likelihood Probable Evidence D
Taurine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemo Rage Black Ultra Concentrate Apple Ambush, from the product label.

Nutrex Research

See all Nutrex Research products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-3NUTREX
Web Address
Nutrex.com
Pharmacist Counseling Corner

Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research: Common Questions

Does Hemo Rage Black Ultra Concentrate Apple Ambush by Nutrex Research interact with any medications?
Yes. Based on its ingredients, Hemo Rage Black Ultra Concentrate Apple Ambush has a known interaction with 1,006 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemo Rage Black Ultra Concentrate Apple Ambush contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for athletic performance?
Caffeine is likely effective for athletic performance, and beta-alanine (CarnoSyn) is possibly effective for both athletic and physical performance. The taurine and L-arginine may also support endurance, though there isn't enough evidence to rate them for this use. The effect will depend on your individual response and training.
What is methylhexaneamine, and why is it in here?
Methylhexaneamine (1,3-DMAA) is a potent synthetic stimulant added for extreme energy and alertness. It's banned in many countries because it's tied to serious cardiovascular harm — heart attack, stroke, and cardiac arrest. This is the single most concerning ingredient in the product.
Can I use this if I'm pregnant or breastfeeding?
No. Huperzine A and beta-alanine should be avoided during pregnancy and breastfeeding — there isn't enough safety data. Caffeine is possibly unsafe in pregnancy. Methylhexaneamine (1,3-DMAA) is unsafe during both. Talk with your doctor or pharmacist about any pre-workout use before, during, or after pregnancy.
What are the most common side effects?
Caffeine commonly causes anxiety, insomnia, jitteriness, and nausea. Beta-alanine causes harmless tingling and flushing on the skin. Taurine can cause constipation, diarrhea, or indigestion. L-arginine may cause bloating, headache, or flushing. Methylhexaneamine can cause rapid heart rate, anxiety, and in rare cases serious cardiovascular events.
Why is there so much sodium in a sports drink?
Sodium helps the body retain fluids during intense exercise and supports electrolyte balance. However, if you take blood pressure medication, lithium, corticosteroids, or have been told by your doctor to limit salt, the sodium content here is a concern — discuss it with your pharmacist.
Is this product safe to combine with other supplements?
This product already contains multiple stimulants (caffeine and methylhexaneamine) and is not recommended with other stimulant supplements or energy products. Check with your pharmacist before combining it with any other supplement or medication — the interactions above apply when you mix it with prescription drugs too.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hemo Rage Black Ultra Concentrate Apple Ambush is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemo Rage Black Ultra Concentrate Apple Ambush label
Go deeper

The Full Monographs Behind Hemo Rage Black Ultra Concentrate Apple Ambush’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Taurine

Interacts with 173 drugs

Taurine is an amino acid your body makes naturally and that you also get from animal foods. It is widely used in energy drinks and sports supplements, and short-term use appears generally sa...

Read the full Taurine monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

1,3-dmaa

Interacts with 321 drugs

DMAA (1,3-dimethylamylamine) is a synthetic stimulant that was sold in pre-workout and weight-loss supplements but has been linked to serious harm, including high blood pressure, heart probl...

Read the full 1,3-dmaa monograph →
Sources

Sources & How We Checked

Hemo Rage Black Ultra Concentrate Apple Ambush's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 408 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
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  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Taurine 21 references
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See these in context on the Taurine monograph →

Caffeine 236 references
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See these in context on the Caffeine monograph →

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1,3-dmaa 21 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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