Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Lutein with Zeaxanthin 40 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Lutein with Zeaxanthin 40 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein with Zeaxanthin 40 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein with Zeaxanthin 40 mg is a dietary supplement by The Vitamin Shoppe with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains 2 active ingredients: lutein and zeaxanthin, both carotenoids (plant pigments) that concentrate in the retina of your eye. Lutein and zeaxanthin are naturally found together in leafy greens and colorful vegetables.

The softgel also contains several inactive ingredients—safflower oil, gelatin, glycerin, purified water, yellow beeswax, soy lecithin, sunflower oil, and tocopherol—that help deliver the actives and maintain the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, the two most common age-related vision problems. Zeaxanthin is also possibly effective for AMD.

For other conditions the facts list—retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, and necrotizing enterocolitis—the evidence does not support use. For zeaxanthin's effects on cognitive decline, Alzheimer disease, asthma, and breast cancer, the evidence is too thin to say either way.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from foods and typical supplement doses is generally well tolerated, with doses up to 20 mg daily showing no adverse effects in trials. Zeaxanthin is also generally well tolerated at typical supplement amounts.

For pregnancy and breastfeeding, both are rated likely safe, but the data on concentrated supplement doses (not just food sources) is limited. If you're pregnant or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Zeaxanthin carries a moderate interaction with antidiabetes drugs—it may theoretically increase the risk of low blood sugar. Check your blood sugar medications (and any others you take) with the search tool before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward two-ingredient eye-support supplement suited to adults concerned about macular degeneration or cataracts. If you take diabetes medication, check your exact drugs before starting because zeaxanthin may affect blood sugar control.

Pregnant or breastfeeding? Talk it over with your doctor or pharmacist first.

Run your complete medication list through the interaction checker on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein with Zeaxanthin 40 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536036493
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218301
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766536036493
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Lutein40 mg--
Zeaxanthin8 mg--

Other ingredients: Safflower Oil, Gelatin, Glycerin, purified Water, yellow Beeswax, Soy Lecithin, Sunflower Oil, Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Reduced eye fatigue associated with digital device use Helps filter blue light Supports macular health

Gluten-free Dairy-free Nut-free Non-GMO Does not contain: Gluten, sugar, salt, artificial colors of flavors.

General Statements

Specialty

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Promise Tested & Trusted

Precautions

Contains: Soy.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) softgel daily, preferably with a meal.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Lutemax is a trademark or OmniActive Health Technologies Ltd.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein with Zeaxanthin 40 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
40 mg per serving Form: Marigold flowers extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
8 mg per serving Form: Marigold flowers extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Safflower Oil, Gelatin, Glycerin, Purified Water, Yellow Beeswax, Soy Lecithin, Sunflower Oil, Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Lutein with Zeaxanthin 40 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein with Zeaxanthin 40 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein with Zeaxanthin 40 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein with Zeaxanthin 40 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein with Zeaxanthin 40 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe: Common Questions

Does Lutein with Zeaxanthin 40 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Lutein with Zeaxanthin 40 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein with Zeaxanthin 40 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually help with macular degeneration?
Both lutein and zeaxanthin are possibly effective for age-related macular degeneration (AMD), meaning there's decent evidence they may help, but we don't yet have the kind of rock-solid proof we'd like. They're most useful as one part of overall eye health, alongside diet and routine eye exams.
Is it safe to take if I'm pregnant?
Both ingredients are rated likely safe in pregnancy, but the safety data on supplement doses specifically is limited—food sources are studied more. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
Both are rated likely safe, and lutein naturally occurs in breast milk. However, data on concentrated supplement doses while nursing is thin, so check with your doctor or pharmacist before starting.
What are the inactive ingredients?
The softgel contains safflower oil, gelatin, glycerin, purified water, yellow beeswax, soy lecithin, sunflower oil, and tocopherol. If you have allergies (especially to soy or gelatin), read the label carefully or talk to your pharmacist.
Are there any side effects?
Lutein at typical supplement doses is generally well tolerated, with no adverse effects reported at doses up to 20 mg daily. Zeaxanthin is also generally well tolerated at standard supplement amounts.
What's the difference between lutein and zeaxanthin?
Both are carotenoids that live in your eye and protect it from oxidative stress. They often work together—they're found together in leafy greens—and this product combines them for that synergy. Zeaxanthin concentrates more in the center of the retina, while lutein spreads wider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein with Zeaxanthin 40 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein with Zeaxanthin 40 mg label
Go deeper

The Full Monographs Behind Lutein with Zeaxanthin 40 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein with Zeaxanthin 40 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team