Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

High Test Ingredients & Drug Interactions

by BioXgenic

High Test label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Test against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Test is a dietary supplement by BioXgenic with 5 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,320 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Test by BioXgenic

Ask about any prescription or over-the-counter medication and we check it for interactions with High Test by BioXgenic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Test by BioXgenic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 14 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,015 mg) without saying how much of each component you get.
  • “Hormone Releasing X Complex” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.
  • “Testosterone Boosting X Complex” is a proprietary blend — the label gives one combined amount (600 mg) without saying how much of each component you get.

High Test contains 14 ingredients, including amino acids, minerals, botanicals, and a spice extract. The amino acids are L-glutamine (for cellular support), L-tyrosine (a thyroid and neurotransmitter precursor), L-arginine (for nitric oxide and blood flow), L-lysine (for immune and connective tissue support), and L-ornithine (linked to athletic performance).

Zinc is a mineral cofactor for immune and reproductive function. The botanical ingredients are beta-sitosterol (from plant sterols, used in prostate support), Tribulus terrestris and Eurycoma longifolia (traditional herbs for sexual function and athletic performance), oats (Avena sativa, for cholesterol and blood sugar), saw palmetto (for prostate health), and fenugreek (Testofen brand, for sexual function and blood sugar).

Bioperine is a black pepper extract used to enhance absorption of other nutrients. Three proprietary blends—Hormone Releasing X Complex, Testosterone Boosting X Complex, and Natural Factors X Complex, plus Prostate Safety X Complex—round out the formula; their individual components are not disclosed on the label.

The capsule also contains gelatin, magnesium stearate, titanium dioxide, and FD&C Blue #1 as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: increase testosterone and sexual vitality.
  • We looked for evidence on: Age-related testosterone deficiency, Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Erectile dysfunction, Male sexual function, Prostate health.
  • The strongest evidence on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Fenugreek is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).

Evidence for the active ingredients in High Test is mixed. Zinc is effective for zinc deficiency and likely effective for Wilson disease.

Oats are likely effective for lowering cholesterol and reducing heart disease risk. L-glutamine is effective for sickle cell disease and possibly effective for HIV-related wasting, postoperative recovery, and critical illness.

L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, though athletic performance is rated possibly ineffective. L-arginine has no established effectiveness rating in the data we hold.

L-lysine is possibly effective for cold sores. Beta-sitosterol is likely effective for benign prostatic hyperplasia and possibly effective for high cholesterol and heart disease.

Tribulus is possibly effective for sexual dysfunction but possibly ineffective for athletic performance. Eurycoma longifolia is possibly effective for sexual desire.

Fenugreek is possibly effective for sexual dysfunction and diabetes. Saw palmetto is possibly ineffective for benign prostatic hyperplasia.

For L-ornithine, GABA, Bioperine, and the proprietary blends, the evidence is insufficient or not established in our data.

The evidence, ingredient by ingredient Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 13 of the 14 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 14 of 14.
  • General safety write-ups exist for 14 of 14.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in High Test are generally well tolerated in the short term. L-glutamine, L-tyrosine, L-arginine, L-lysine, L-ornithine, and oats are well tolerated orally at typical doses, though long-term safety data for many are limited.

Zinc is well tolerated below 40 mg daily; higher doses may increase copper deficiency risk. Common mild side effects include gastrointestinal upset (nausea, diarrhea, bloating, constipation), headache, and fatigue.

GABA may cause drowsiness and muscle weakness. Bioperine (black pepper) is well tolerated as a food spice but less studied at supplement concentrations.

Tribulus and Eurycoma longifolia may increase testosterone; if levels go too high, acne, insulin resistance, and liver effects are possible. Saw palmetto rarely causes cardiovascular effects like heart block or irregular heartbeats.

Fenugreek can cause severe allergic reactions including anaphylaxis in sensitive people. Pregnancy and lactation safety varies by ingredient: L-glutamine and oats are rated likely safe in pregnancy; L-tyrosine, L-arginine, and Bioperine lack sufficient data; L-ornithine, GABA, beta-sitosterol, tribulus, saw palmetto, and Eurycoma longifolia are best avoided in pregnancy and lactation.

L-lysine data on supplement use in pregnancy and lactation are insufficient—food sources are fine. Fenugreek is likely unsafe in pregnancy but possibly safe for lactation.

Side effects, ingredient by ingredient Zinc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 12 of the 14 matched ingredients can interact with medications — Tribulus, Lysine, Gamma-aminobutyric Acid (gaba), Fenugreek, Black Pepper, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,321 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking High Test, double-check these medication types with your doctor or pharmacist. Most serious: anticonvulsant (seizure) medications may be antagonized by L-glutamine.

Blood pressure-lowering drugs (antihypertensives, ACE inhibitors, ARBs) could have stronger effects when combined with L-arginine, GABA, or tribulus. Diabetes medications and insulin may cause dangerously low blood sugar if combined with L-arginine, oats, fenugreek, or tribulus.

Blood thinners (warfarin) and antiplatelet drugs (clopidogrel, aspirin) may have increased effects with L-arginine, saw palmetto, or fenugreek. Antibiotics—especially quinolones, tetracyclines, cephalexin, and penicillamine—have reduced absorption with zinc; space doses 2–6 hours apart.

HIV drugs (ritonavir, integrase inhibitors, bictegravir combinations) may have lower levels with zinc. Thyroid hormones may have stronger effects with L-tyrosine.

Levodopa (Parkinson's) absorption may be reduced by L-tyrosine. Seizure medications like phenytoin may have higher levels with Bioperine.

Lithium levels may rise with tribulus. Several other drug types are also affected—ask your pharmacist to run the full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

High Test is a multingredient formula aimed at sexual function, athletic performance, and prostate health. It may help with those goals for some people, but the evidence is stronger for some ingredients than others.

Because it contains multiple ingredients that interact with common medications—especially blood pressure drugs, diabetes drugs, blood thinners, antibiotics, seizure medications, and thyroid hormones—you'll want to check your exact medications with your doctor or pharmacist before starting. If you're pregnant, breastfeeding, or managing a chronic condition, discuss this product with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 14 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Test, straight from the product label.

Brand BioXgenic
Barcode (UPC) 699439000400
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 76216
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Test by BioXgenic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Cap(s)
Maximum serving Sizes:
1 Cap(s)
Servings per container
30
UPC/BARCODE
699439000400
IngredientAmount% DV
L-Glutamine0 NP--
L-Tyrosine0 NP--
Zinc30 mg200%
Proprietary Blend2015 mg--
GABA0 NP--
Beta-Sitosterol0 NP--
L-Arginine0 NP--
L-Lysine0 NP--
L-Ornithine0 NP--
Bioperine0 NP--
Hormone Releasing X Complex525 mg--
Testosterone Boosting X Complex600 mg--
Natural Factors X Complex500 mg--
Tribulus terrestris0 NP--
Eurycoma longifolia0 NP--
Avena sativa0 NP--
Prostate Safety X Complex390 mg--
Saw Palmetto0 NP--
Testofen0 NP--

Other ingredients: Gelatin, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Supreme blend of 14 herbs and amino acids to increase testosterone and increase sexual vitality.

Provides prostate protective factors.

Daily supplements for sexual health

Testosterone booster Promotes lean body mass and strength Increases testosterone naturally Libido and energy enhancer Prostate protection

Our advanced formula offers a unique three pronged testosterone boosting formula with a fourth prong that has prostate protective factors.

Also accelerates tissue repair to reduce recovery time following an injury.

Also helps reduce fatigue following exercise.

New Physician approved

Naturally supporting sexual health

Additional benefits: Increased energy and libido. Assists in forming lean body mass.

Frequency of sexual intercourse Times/week Active Placebo Baseline | Week 3 | Week 6

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule (3) times a day. For maximum effectiveness, this product should be used daily.

Also: Use for a minimum of two months. For best results continue using daily.

Formula

Caution: For men only.

Keep out of reach of children.

Contains clinically proven testosterone booster Testofen

Prong 1: Hormone Releasing X Complex: Specific amino acids have been shown to induce production of growth hormone. L-Arginine increases levels of growth hormone in the body.

L-Ornithine increases human growth hormone levels.

Prong 2: Testosterone Boosting X Complex: Testofen 600mg per day- published clinical studies show it supports free testosterone levels, helps maintain muscle mass and supports reduction in body fat.

Prong 3: Natural Factors X Complex: Tribulus terrestris has been used in traditional Chinese and Indian Ayurvedic medicine to help with stronger, more frequent erections, higher volume of ejaculate and improved muscular density. Prong 4: Prostate Safety X Complex: Increasing testosterone can also cause prostate growth so this prong is an added protection for men over 40. Saw palmetto supports prostate and urinary health in men. Beta sitosterol can bind to the prostate and reduce inflammation. Bioperine-maximizes absorption and increases bioavailability.

Prong 4: Prostate Safety X Complex: Increasing testosterone can also cause prostate growth so this prong is an added protection for men over 40.

Contains clinically proven testofen testosterone booster and prostate protective factors

Male performance

Precautions

Caution: For men only. Not to be taken by those under 18 years of age, or those with hormone-related cancers. Use as directed.

Not to be taken by those under 18 years of age, or those with hormone-related cancers.

If you are using any prescription drug, or have a medical condition, consult your doctor before using this product.

Discontinue use two weeks prior to surgery. If erection last longer than 4 hours, please consult your physician.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

3011-011817

FDA Statement of Identity

Herbal Dietary Supplement

Brand IP Statement(s)

Bioperine is a trademark of Sabinsa Corporation. Testofen and Fenuside are trademarks of Gencor.

Testofen clinical studies show that men using the recommended dose went from having sex once a week to 2.5 times a week, after 3 weeks of use.

Please visit BioXgenic.com to read the Testofen clinical study.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Test by BioXgenic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Test label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Test by BioXgenic

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
30 mg per serving Form: Zinc Oxide

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Proprietary Blend

2015 mg per serving
  • › Hormone Releasing X Complex
  • › Testosterone Boosting X Complex
  • › Natural Factors X Complex
  • › Prostate Safety X Complex

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Test by BioXgenic Drug Interactions

Want to check YOUR meds against High Test?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,320Drugs
1,201 Moderate 119 Minor

Ingredients driving the most interactions

Zinc 67

Individual Drug Interactions

The ingredients in High Test interact with 1,320 drugs. Click any drug to see the details.

1 of the 5 ingredients in High Test interact with drugs. Each result below shows which ingredient is responsible. Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in High Test with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Test, from the product label.

BioXgenic

See all BioXgenic products
Name
MD Science Lab LLC
City
Pompano Beach
State
FL
ZipCode
33069
Phone Number
954-725-5502
Web Address
BioXgenic.com
Pharmacist Counseling Corner

High Test by BioXgenic: Common Questions

Does High Test by BioXgenic interact with any medications?
Yes. Based on its ingredients, High Test has a known interaction with 1,320 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Test contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product lower my blood pressure?
Possibly. L-arginine, GABA, and tribulus can all theoretically lower blood pressure based on clinical research. If you take blood pressure medication, this product could increase that effect and cause your pressure to drop too far. Check with your doctor or pharmacist before starting.
Can I take this if I'm on diabetes medication?
Potentially not without supervision. L-arginine, oats, fenugreek, and tribulus can all lower blood sugar. Combining them with your diabetes drug—especially insulin—raises the risk of dangerously low blood sugar (hypoglycemia). Talk to your doctor first.
What's Testofen and why is it in here?
Testofen is a branded fenugreek seed extract used for sexual function and testosterone support. Fenugreek is possibly effective for sexual dysfunction and diabetes. It can cause GI upset (diarrhea, bloating, nausea) and rare severe allergies.
Is it safe to take this while pregnant?
Several ingredients lack enough pregnancy safety data, and some—like tribulus, saw palmetto, and fenugreek—are best avoided during pregnancy because of possible hormonal effects. L-glutamine and oats are rated likely safe. Talk to your doctor or midwife before use.
Does this product have fillers?
Yes. The inactive ingredients include gelatin (capsule material), magnesium stearate (a lubricant), titanium dioxide (a coloring agent), and FD&C Blue #1 (a dye). It also contains three proprietary blends whose individual components are not listed on the label.
Can I take this with antibiotics?
Zinc in this product can reduce absorption of several antibiotics, including quinolones, tetracyclines, cephalexin, and penicillamine. Space doses 2–6 hours apart and tell your pharmacist you're taking a zinc supplement so they can advise on timing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Test label
Go deeper

The Full Monographs Behind High Test’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

High Test's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 304 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Tyrosine 4 references
  1. Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
  2. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  3. Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
  4. van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed

See these in context on the Tyrosine monograph →

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
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Ornithine 1 reference
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Tribulus 10 references
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Saw Palmetto 22 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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