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Dietary supplement

Hops 300 mg Ingredients & Drug Interactions

by Natural Grocers by Vitamin Cottage

Hops 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hops 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hops 300 mg is a dietary supplement by Natural Grocers by Vitamin Cottage with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hops. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hops 300 mg by Natural Grocers by Vitamin Cottage

Ask about any prescription or over-the-counter medication and we check it for interactions with Hops 300 mg by Natural Grocers by Vitamin Cottage — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hops 300 mg by Natural Grocers by Vitamin Cottage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: hops, 300 mg per capsule. Hops is a plant commonly used in brewing; the part used here is the flower cluster.

The capsule also holds inactive ingredients—microcrystalline cellulose (a binder), silica and rice bran (flow agents), and the capsule material itself.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Women's health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence on hops for the conditions listed—age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion, and insomnia—is insufficient to establish whether it works. We hold no reliable data showing benefit for any of these uses.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops is generally well tolerated for short-term use but may cause drowsiness. Long-term safety hasn't been well studied.

The safety data advises against use during pregnancy. There isn't enough safety information to know whether it's safe while breastfeeding—talk it over with your doctor or pharmacist.

Oral supplements combining hops and soy have been linked in a few cases to postmenopausal bleeding, though it's unclear whether hops alone is responsible. Occupational exposure to hops dust (usually mixed with other dusts) has been tied to chronic respiratory symptoms like cough and bronchitis, but that's from workplace inhalation, not oral supplements.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Hops 300 mg, double-check with your doctor or pharmacist if you take any sedatives or sleep aids (the most serious interaction), estrogen-based hormone replacement therapy or birth control, or medications that depend on liver metabolism (CYP3A4 or CYP1A2 substrates). The interaction with sedatives is Moderate; the others are Moderate to Minor but still worth confirming.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Hops may help some people relax, but the evidence for specific health benefits isn't established yet. If you take sedatives, hormone medications, or drugs metabolized through your liver, check your medications with your doctor or pharmacist before starting—the interactions are moderate to minor but real.

Avoid hops during pregnancy and breastfeeding. Talk it over with your own healthcare provider about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hops 300 mg, straight from the product label.

Brand Natural Grocers by Vitamin Cottage
Barcode (UPC) 849327002966
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 256734
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hops 300 mg by Natural Grocers by Vitamin Cottage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
90
UPC/BARCODE
849327002966
IngredientAmount% DV
Hops300 mg--

Other ingredients: Capsule, Microcrystalline Cellulose, Silica, Rice Bran

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) vegetarian capsule daily, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Formulation

We only put our name on formulas that meet our unrivaled quality standards, and we continue raising the bar on these standards without raising the bar on your budget. Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients. We scrutinize every detail, so you don't have to, because we are, and always have been, your Original good4u Grocers. To your health, - The Isely Family

Our supplements are GMP (Good Manufacturing Practices) certified, ingredient verified, screened for heavy metals, and formulated without questionable fillers, artificial colors, sweeteners, flavors, and other problematic ingredients.

Gluten free

Vegetarian

Made in USA

BPA Free

Contains no: Sugar, salt, dairy, yeast, wheat, gluten, corn, soy, preservatives, magnesium stearate, artificial colors or flavors.

Seals/Symbols

GMP Good Manufacturing Practice

Formula

Women's health

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: As with any supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, or are under medical supervision for any reason.

For serious adverse event reporting call (877-455-2826.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hops 300 mg by Natural Grocers by Vitamin Cottage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hops 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hops 300 mg by Natural Grocers by Vitamin Cottage

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Hops

Interacts with
863 drugs
300 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Hops monograph & interactions

Other (inactive) ingredients: Capsule, Microcrystalline Cellulose, Silica, Rice Bran. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hops 300 mg by Natural Grocers by Vitamin Cottage Drug Interactions

Want to check YOUR meds against Hops 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Hops 863

Individual Drug Interactions

The ingredients in Hops 300 mg interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hops 300 mg interact with drugs. Each result below shows which ingredient is responsible. Hops

Each ingredient & the kinds of drugs it affects

For each ingredient in Hops 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hops4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hops 300 mg, from the product label.

Natural Grocers by Vitamin Cottage

See all Natural Grocers by Vitamin Cottage products
Name
Vitamin Cottage Natural Food Markets, Inc.
City
Lakewood
State
CO
ZipCode
80228
Phone Number
877-455-2826
Web Address
www.naturalgrocers.com
Pharmacist Counseling Corner

Hops 300 mg by Natural Grocers by Vitamin Cottage: Common Questions

Does Hops 300 mg by Natural Grocers by Vitamin Cottage interact with any medications?
Yes. Based on its ingredients, Hops 300 mg has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hops 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a sleeping pill or anti-anxiety medication?
No, not without checking first. Hops may add to the drowsy or sedating effects of those drugs, which could leave you too impaired. Talk with your doctor or pharmacist before combining them.
Is hops safe during pregnancy?
No. The safety data advises against hops during pregnancy. Talk with your doctor or pharmacist if you're pregnant or planning to be.
What about breastfeeding?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist for personalized advice if you're breastfeeding.
Will this actually help my anxiety or sleep?
The evidence we hold is insufficient to say whether hops works for anxiety, insomnia, or the other conditions listed. There's not enough reliable research to establish benefit.
What's the inactive ingredient list?
The capsule itself, microcrystalline cellulose (a binder), silica and rice bran (flow agents). No major fillers or artificial additives beyond those.
Could this cause drowsiness even if I'm not on other drugs?
Yes—hops may cause drowsiness on its own. The safety data notes this as a possible effect, so don't drive or operate machinery until you see how you react.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hops 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hops 300 mg label
Go deeper

The Full Monographs Behind Hops 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Hops 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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