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Dietary supplement

Hops Extract Ingredients & Drug Interactions

by BulkSupplements.com

Hops Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hops Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hops Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hops extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hops Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Hops Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hops Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: hops extract, a concentrated form of the flowering cone of the hop plant. Hops has been used traditionally to promote relaxation and sleep, and also shows activity at estrogen receptors in the body.

There are no inactive ingredients listed for this powder form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hops product and its label doesn't state a use — see Hops's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that hops extract is effective for age-related cognitive decline, sexual dysfunction, anxiety, ADHD, dyspepsia, or insomnia. While hops has been used traditionally for relaxation and sleep, the research available to us rates all of these uses as insufficient reliable evidence.

If you're considering hops for any of these reasons, talk it over with your doctor to explore options with stronger evidence behind them.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops extract is generally well tolerated for short-term use but may cause drowsiness—so don't drive or operate machinery if it makes you sleepy. Long-term safety hasn't been well studied, so we don't have solid data on what happens if you take it regularly for months or years.

The safety data advises against hops during pregnancy and while breastfeeding, as there isn't enough information to know it's safe in those situations. Occupational exposure to hops dust is linked to chronic respiratory symptoms like dry cough and bronchitis, though this typically occurs in workers handling large amounts over time.

A small number of case reports link hops supplements (usually combined with soy) to postmenopausal bleeding, though it's unclear whether hops, soy, the combination, or something else caused it. Allergic contact reactions have been reported from touching the fresh plant and its dust.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take sedatives, sleep aids, anti-anxiety medications, or any drug that slows your central nervous system, talk with your doctor or pharmacist before using hops—it may add to the drowsiness. Anyone on estrogen-based hormone replacement therapy should also check first, as large amounts of hops might reduce the therapy's effectiveness.

Finally, if you take medications metabolized by CYP1A2 or CYP3A4 liver enzymes, confirm with your pharmacist that hops won't interfere, though the real-world risk is thought to be small.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Hops extract is traditionally used for relaxation and sleep, but we don't have enough reliable evidence to confirm it works for any condition. If you take sedatives, hormone medications, or many other prescription drugs, check with your doctor or pharmacist before starting—the sedative effect and estrogen interactions are worth discussing.

Keep in mind that long-term safety isn't well studied, and pregnancy and breastfeeding aren't recommended.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hops Extract, straight from the product label.

Brand BulkSupplements.com
Net contents 100 Gram(s); 3.53 Ounce(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254774
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hops Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
520 mg
Maximum serving Sizes:
520 mg
Servings per container
192
IngredientAmount% DV
Hops extract520 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

US standard measuring spoons Spoon size (level) milligrams 1/4 teaspoon 520 1/2 teaspoon 1040 1 teaspoon 2080 Powder density may vary. For accurate measurement, a milligram scale is necessary.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Free of: Sugar, soy, dairy, yeast, gluten or additives.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 520 mg (1/4 tsp) daily, or directed by a physician.

Storage

Storage: Keep dry, cool & dark.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hops Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hops Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hops Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size520 mg Dosage formPowder Servings per container192 Amounts shown are per serving.

Hops extract

Interacts with
863 drugs
520 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Hops extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hops Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Hops Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Hops extract 863

Individual Drug Interactions

The ingredients in Hops Extract interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hops Extract interact with drugs. Each result below shows which ingredient is responsible. Hops extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hops Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hops extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hops Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Road
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Hops Extract by BulkSupplements.com: Common Questions

Does Hops Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Hops Extract has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hops Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take hops extract while I'm pregnant?
No, the safety data advises against it. There isn't enough information to know it's safe during pregnancy, so it's best avoided. Talk with your doctor or pharmacist before taking any new supplement while pregnant.
Is it safe to use hops while breastfeeding?
No, safety is unknown while breastfeeding, so it should be avoided. If you're nursing and interested in hops for any reason, discuss it with your doctor or pharmacist first.
Will hops extract help me sleep?
Hops has been used traditionally for sleep, but the research we have rates the evidence as insufficient to confirm it works. If you're looking for a sleep aid, talk with your doctor about options with stronger evidence behind them.
Can hops extract cause drowsiness?
Yes, drowsiness is a possible side effect. Because hops can sedate, don't drive or use machinery until you know how it affects you. Be especially cautious if you take other sedative medications.
What should I know about taking hops long-term?
Long-term safety hasn't been well studied, so we don't have solid data on what happens with regular, extended use. If you're considering taking hops for weeks or months, check with your doctor or pharmacist first.
Does hops extract interact with hormone replacement therapy?
Theoretically, large amounts of hops might interfere with HRT by competing for estrogen receptors, though most hops extracts contain only small amounts of the active constituents responsible. If you're on HRT, confirm with your doctor or pharmacist before starting hops.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hops Extract label
Go deeper

The Full Monographs Behind Hops Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Hops Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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