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Dietary supplement

Horny Goat Weed Ingredients & Drug Interactions

by GNC Men's

Horny Goat Weed label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horny Goat Weed against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horny Goat Weed is a dietary supplement by GNC Men's with 2 active ingredients. Its ingredients are commonly taken for low libido and sexual function, energy and stamina, menopause symptoms.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horny Goat Weed by GNC Men's

Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed by GNC Men's — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horny Goat Weed by GNC Men's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Horny Goat Weed Aerial Parts Extract is the primary ingredient — it's the flowering and leafy parts of the plant.

Maca root extract comes from a plant root and is included as a second active component. Both are plant extracts meant to support the product's intended use.

The capsule also contains inactive ingredients (gelatin, microcrystalline cellulose, magnesium stearate, silicon dioxide, and sodium lauryl sulfate) that serve as binders, fillers, and capsule material.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support sexual health.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual desire, Sexual dysfunction, Antidepressant-induced sexual dysfunction, Male infertility, Age-related testosterone deficiency — and 4 related terms.
  • The closest evidence on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction (Natural Medicines).
  • Also on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Postmenopausal conditions, Sexual desire, Age-related testosterone deficiency, Male infertility.
  • Also on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction, Erectile dysfunction (ED).

The evidence we have doesn't establish that this product works. Both Horny Goat Weed and Maca root are rated as having insufficient reliable evidence for the conditions they're marketed for — including sexual dysfunction, which is what this product appears to be formulated for.

That means the studies either don't exist, aren't strong enough, or are too limited to say whether it actually helps.

The evidence, ingredient by ingredient Maca Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horny Goat Weed is generally well tolerated in the short term, though the safety data is limited and quality varies between products. The most common side effects are dizziness, dry mouth, nosebleed, thirst, and vomiting.

Maca root is generally well tolerated as a food, but long-term supplement safety hasn't been studied. One rare case of a serious heart rhythm problem (tachyarrhythmia) was reported after taking horny goat weed, though it's unclear whether it was the sole ingredient responsible.

Due to insufficient safety data, avoid this product during pregnancy and while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your pharmacist or doctor before taking it.

Side effects, ingredient by ingredient Maca Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Horny Goat Weed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on blood thinners or antiplatelet medications (like warfarin or aspirin) — Horny Goat Weed may increase bleeding risk. Also check blood pressure medications (it may lower pressure further), estrogen-containing drugs, and any medications your liver breaks down using CYP1A2, CYP2B6, or CYP3A4 enzymes — Horny Goat Weed may boost their effects and side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

The evidence doesn't show this product works for its intended purpose. If you're considering it anyway, you need to check your medications first — it interacts with blood thinners, blood pressure drugs, and several other types of medication your liver processes.

Talk with your pharmacist before starting, especially if you take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horny Goat Weed, straight from the product label.

Brand GNC Men's
Barcode (UPC) 048107173449
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 315302
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horny Goat Weed by GNC Men's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
048107173449
IngredientAmount% DV
Maca root extract250 mg--
Horny Goat Weed Aerial Parts Extract600 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Contains a bioengineered food ingredient.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

General Statements

For more information: 1-888-462-2548 GNC.com

30-day supply

FDA Statement of Identity

Dietary Supplement

Formulation

Traditionally used to support sexual health

No artificial colors, no artificial flavors, gluten free, no milk.

Formula

600 mg horny goat weed 250 mg maca extract

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two capsules daily. For best results, take before activity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horny Goat Weed by GNC Men's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horny Goat Weed label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horny Goat Weed by GNC Men's

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Maca root extract

No known
interactions
250 mg per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Maca root extract monograph & interactions

Horny Goat Weed Aerial Parts Extract

Interacts with
963 drugs
600 mg per serving

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed Aerial Parts Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horny Goat Weed by GNC Men's Drug Interactions

Want to check YOUR meds against Horny Goat Weed?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
963 Moderate

Ingredients driving the most interactions

Horny Goat Weed Aerial Parts Extract 963

Individual Drug Interactions

The ingredients in Horny Goat Weed interact with 963 drugs. Click any drug to see the details.

1 of the 2 ingredients in Horny Goat Weed interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Aerial Parts Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horny Goat Weed with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed Aerial Parts Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed Aerial Parts Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horny Goat Weed, from the product label.

GNC Men's

See all GNC Men's products
Name
GNC Holdings, LLC
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
GNC.com
Pharmacist Counseling Corner

Horny Goat Weed by GNC Men's: Common Questions

Does Horny Goat Weed by GNC Men's interact with any medications?
Yes. Based on its ingredients, Horny Goat Weed has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horny Goat Weed contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's actually in this product?
Two active plant extracts: Horny Goat Weed Aerial Parts and Maca root. The rest is capsule material and inactive fillers like gelatin and cellulose.
Does it work?
The evidence doesn't tell us. Both ingredients are rated as having insufficient reliable evidence for the conditions they're used for, including sexual dysfunction.
What side effects might I get?
Short-term use seems to cause dizziness, dry mouth, nosebleed, thirst, and vomiting in some people. Long-term safety hasn't been well studied. One rare case of a serious heart rhythm problem was reported, though it's unclear if horny goat weed caused it.
Can I take this if I'm pregnant or breastfeeding?
No — there isn't enough safety data. Avoid it during pregnancy and while breastfeeding. Talk with your pharmacist or doctor if you have questions about your individual situation.
Why do I need to check my medications?
Horny Goat Weed may interact with blood thinners, blood pressure drugs, estrogen medications, and several others your liver processes. It could increase your bleeding risk or boost how much of those drugs your body absorbs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horny Goat Weed is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horny Goat Weed label
Go deeper

The Full Monographs Behind Horny Goat Weed’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Horny Goat Weed's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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