Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Horny Goat Weed & Maca Ingredients & Drug Interactions

by TerraVita

Horny Goat Weed & Maca label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horny Goat Weed & Maca against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horny Goat Weed & Maca is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed And Maca Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Horny Goat Weed & Maca by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed & Maca by TerraVita — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Horny Goat Weed & Maca by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Horny Goat Weed And Maca Glycerite Liquid Extract” is listed as a grouped ingredient — the label gives one combined amount (0.13 mg) without saying how much of each component you get.

This liquid contains 2 active ingredients: Maca Glycerite Liquid Extract and Horny Goat Weed Glycerite Liquid Extract. Both are plant extracts in glycerin, a sweet liquid that acts as a preservative and carrier.

The product contains no other active ingredients — just glycerin as the inactive ingredient.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Sexual function and vitality support.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual desire, Sexual dysfunction, Antidepressant-induced sexual dysfunction, Age-related testosterone deficiency, Male infertility — and 4 related terms.
  • The closest evidence on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Antidepressant-induced sexual dysfunction (Natural Medicines).
  • Also on file: Maca is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Fatigue, Sexual desire, Age-related testosterone deficiency, and more.
  • Also on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction.

The evidence for what either ingredient does isn't established in our data. Both maca and horny goat weed have been studied for various uses — sexual function, bone health, athletic performance, and others — but the data we hold rates all of these as having insufficient reliable evidence to rate.

That means the research so far hasn't been strong enough to say they work.

The evidence, ingredient by ingredient Horny Goat Weed Maca

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Horny goat weed is generally well tolerated in the short term, but human safety data is limited and product quality varies. The most common side effects are dizziness, dry mouth, nosebleed, thirst, and vomiting.

Long-term use has been linked to reports of vomiting, dry mouth, thirst, and nosebleed. Maca is generally well tolerated as food, though fresh uncooked maca may cause stomach pain; long-term supplement safety hasn't been studied well.

For pregnancy: Horny goat weed is rated possibly unsafe, so avoid it if you're pregnant. Maca has not enough safety data, so avoid it too.

For breastfeeding: neither ingredient has reliable safety data, so avoid while nursing. Talk with your doctor or pharmacist before taking this if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Horny Goat Weed Maca

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Horny Goat Weed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check with your pharmacist if you take blood thinners or antiplatelet drugs like warfarin or aspirin (moderate risk of increased bleeding), blood pressure medications (moderate risk of low blood pressure), estrogen-based medications including birth control (moderate risk of increased hormone effects), or any drugs processed by liver enzymes CYP1A2, CYP2B6, or CYP3A4 — a very common group that includes many pain relievers, statins, and others (moderate risk of increased drug effects).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product might interest you if you're looking for a traditional herbal approach, but the evidence for its effects isn't solid yet. Because horny goat weed interacts with blood thinners, blood pressure drugs, hormone medications, and drugs processed by certain liver enzymes, check your medications first.

If you're pregnant or breastfeeding, avoid it. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horny Goat Weed & Maca, straight from the product label.

Brand TerraVita
Barcode (UPC) 064435225872
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279718
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horny Goat Weed & Maca by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064435225872
IngredientAmount% DV
Maca Glycerite Liquid Extract0 NP--
Horny Goat Weed And Maca Glycerite Liquid Extract0.13 mg--
Horny Goat Weed Glycerite Liquid Extract0 NP--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horny Goat Weed & Maca by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horny Goat Weed & Maca label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horny Goat Weed & Maca by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Horny Goat Weed And Maca Glycerite Liquid Extract

Interacts with
963 drugs
0.13 mg per serving

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed And Maca Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horny Goat Weed & Maca by TerraVita Drug Interactions

Want to check YOUR meds against Horny Goat Weed & Maca?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
963 Moderate

Ingredients driving the most interactions

Horny Goat Weed And Maca Glycerite Liquid Extract 963

Individual Drug Interactions

The ingredients in Horny Goat Weed & Maca interact with 963 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horny Goat Weed & Maca interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed And Maca Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horny Goat Weed & Maca with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed And Maca Glycerite Liquid Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed And Maca Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horny Goat Weed & Maca, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Horny Goat Weed & Maca by TerraVita: Common Questions

Does Horny Goat Weed & Maca by TerraVita interact with any medications?
Yes. Based on its ingredients, Horny Goat Weed & Maca has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horny Goat Weed & Maca contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my birth control?
Not without checking with your pharmacist first. Horny goat weed may increase estrogen levels, which could affect how your birth control works. Your pharmacist can review your specific medication.
Is this safe while I'm pregnant?
No. Horny goat weed is rated possibly unsafe in pregnancy, and maca doesn't have enough safety data. Talk with your doctor before considering any supplement during pregnancy.
What are the side effects?
The most common ones from horny goat weed are dizziness, dry mouth, nosebleed, thirst, and vomiting. Maca may cause stomach pain if it's fresh and uncooked. Serious side effects are rare but have been reported.
Does this actually work for sexual function?
The evidence isn't established yet. Both horny goat weed and maca have been studied for sexual function, but the research so far rates it as insufficient to say whether it works.
Can I take this long-term?
Long-term safety hasn't been well studied for either ingredient. Horny goat weed has links to vomiting, dry mouth, thirst, and nosebleed with longer use. Stick to short-term use and talk with your pharmacist about your timeline.
What's glycerin doing in there?
Glycerin is a natural preservative and carrier liquid that keeps the herbal extracts stable and makes them easier to mix or drink. It's not an active ingredient — just part of how the product is made.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horny Goat Weed & Maca is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horny Goat Weed & Maca label
Go deeper

The Full Monographs Behind Horny Goat Weed & Maca’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph →
Sources

Sources & How We Checked

Horny Goat Weed & Maca's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team