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Dietary supplement

Horse Chestnut 300 mg Ingredients & Drug Interactions

by NOW

Horse Chestnut 300 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horse Chestnut 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horse Chestnut 300 mg is a dietary supplement by NOW with 2 active ingredients. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horse Chestnut Fruit, Seed Extract, Rutin, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horse Chestnut 300 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Horse Chestnut 300 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horse Chestnut 300 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Horse Chestnut Fruit, Seed Extract” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.

This product has 2 active ingredients: rutin powder and horse chestnut fruit seed extract (a concentrated form). Rutin is a plant flavonoid — a type of compound with antioxidant properties — while horse chestnut seed extract has been used traditionally for circulation and vein health.

The capsule also contains inactive ingredients like hypromellose (a plant-based capsule), calcium citrate, silicon dioxide, and stearic acid to help the capsule hold together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rutin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Circulatory support and vascular system integrity.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Hemorrhoids, Postoperative swelling, Lymphedema, Leg swelling — and 2 related terms.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Lymphedema, Varicose veins, Postoperative swelling.

The evidence we hold on rutin doesn't establish it works for the conditions listed — aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-related respiratory infections, and hemorrhoids all fall into the category of insufficient reliable evidence to rate. We don't have effectiveness data on file for horse chestnut seed extract either.

The evidence, ingredient by ingredient Rutin Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated when you eat it in food and take it short-term as a supplement, but long-term safety data at higher supplement doses are limited. Some people report headache, flushing, or rashes when taking rutin by mouth.

We don't have enough safety information on rutin at supplement doses to recommend it outside of medical supervision, and safety during breastfeeding is unknown — so avoid supplement doses if you're nursing unless your doctor says otherwise. Rutin is rated likely safe during pregnancy, but always check with your obstetrician or midwife before starting any supplement in pregnancy.

Side effects, ingredient by ingredient Rutin Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (Moderate interaction), check with your pharmacist before starting. We couldn't check all the saponin compounds in horse chestnut seed extract, so your pharmacist should verify your exact medications against the interaction checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking antidiabetes medications, talk to your pharmacist before adding this product — the rutin in it may lower your blood sugar further. Even if you don't take diabetes drugs, the long-term safety data are thin, so this isn't a go-to choice unless your doctor specifically recommends it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horse Chestnut 300 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047137
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 314390
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horse Chestnut 300 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
90
UPC/BARCODE
733739047137
IngredientAmount% DV
Rutin, Powder200 mg--
Horse Chestnut Fruit, Seed Extract300 mg--
Triterpenoid Saponins60 mg--

Other ingredients: Hypromellose, Calcium Citrate, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: Take 1 capsule daily.

Formula

Horse Chestnut (Aesculus hippocastanum) is commonly used in European herbalism. It has many active constituents, including saponins and flavones, which have been scientifically shown to support the integrity of the vascular system and connective tissue. Rutin, a powerful free radical scavenger, has been added to complete this formula.

Horse Chestnut standardized extract Horse Chestnut with added Rutin

Triangle K (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Contains tree nut (horse chestnut).

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that process other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Circulatory support

Non-GMO

Vegetarian/vegan

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Made and quality tested in the USA with globally sourced ingredients.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP Quality Assured

Brand IP Statement(s)

Botanicals/herbs Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horse Chestnut 300 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horse Chestnut 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horse Chestnut 300 mg by NOW

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rutin, Powder

Interacts with
86 drugs
200 mg per serving Form: Sophora japonica

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin, Powder monograph & interactions

Horse Chestnut Fruit, Seed Extract

Interacts with
122 drugs
300 mg per serving Form: Aesculus hippocastanum Fruit Extract, Aesculus hippocastanum Seed Extract

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horse Chestnut Fruit, Seed Extract monograph & interactions
  • › Triterpenoid Saponins

Other (inactive) ingredients: Hypromellose, Calcium Citrate, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horse Chestnut 300 mg by NOW Drug Interactions

Want to check YOUR meds against Horse Chestnut 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Horse Chestnut Fruit, Seed Extract 122
Rutin, Powder 86

Individual Drug Interactions

The ingredients in Horse Chestnut 300 mg interact with 208 drugs. Click any drug to see the details.

2 of the 2 ingredients in Horse Chestnut 300 mg interact with drugs. Each result below shows which ingredient is responsible. Horse Chestnut Fruit, Seed Extract Rutin, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Horse Chestnut 300 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horse Chestnut Fruit, Seed Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horse Chestnut Fruit, Seed Extract full monograph & interactions

Rutin, Powder1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horse Chestnut 300 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
nowfoods.com
Pharmacist Counseling Corner

Horse Chestnut 300 mg by NOW: Common Questions

Does Horse Chestnut 300 mg by NOW interact with any medications?
Yes. Based on its ingredients, Horse Chestnut 300 mg has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horse Chestnut 300 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Rutin is rated likely safe in pregnancy — but always talk with your obstetrician first. For breastfeeding, there isn't enough safety data, so the facts advise against supplement doses unless your doctor says it's okay.
What are the possible side effects?
Rutin may cause headache, flushing, or rashes in some people. Long-term safety at supplement doses isn't well studied, so we know less about what happens with regular, long-term use.
Does this actually work for anything?
The evidence we hold doesn't establish that rutin works reliably for the conditions listed on this product — they're all rated insufficient evidence. We don't have effectiveness data on file for horse chestnut seed extract either.
Why does the interaction checker show 85 medications?
That's the total count of individual drugs that interact with rutin, the one ingredient we could fully check. Many of those are different antidiabetes medications — the main risk category for this product.
Is it safe to take with my blood pressure medicine?
We don't have documented interactions between rutin and blood pressure drugs in our data, but you should always verify your exact medication with the checker on this page or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horse Chestnut 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horse Chestnut 300 mg label
Go deeper

The Full Monographs Behind Horse Chestnut 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph → Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Horse Chestnut 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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