No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Hyaluronic Acid Ingredients & Drug Interactions

by Mental Refreshment

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Hyaluronic Acid is a dietary supplement by Mental Refreshment with 1 active ingredient. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Hyaluronic Acid by Mental Refreshment

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: hyaluronic acid, a naturally occurring compound that holds water in skin and connective tissues. The capsule is filled with inactive ingredients—gelatin and rice powder—which serve as the capsule material and filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy joints and youthful skin hydration.
  • We looked for evidence on: Aging skin, Osteoarthritis, Wound healing, Dry eye, Joint mobility, Skin elasticity.
  • The strongest evidence on file: Hyaluronic Acid is rated "Possibly Effective" for Dry eye (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin, Osteoarthritis, Wound healing.

Hyaluronic acid is possibly effective for dry eye and for venous leg ulcers (slow-healing sores on the legs related to circulation). For aging skin, hay fever, and sexual dysfunction, the evidence we hold isn't reliable enough to rate its effectiveness either way.

If you're considering it for one of those other uses, talk it over with your doctor about what the current science actually supports.

The evidence, ingredient by ingredient Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hyaluronic acid taken by mouth appears to be well tolerated overall in adults. That said, long-term safety of supplements hasn't been fully studied, and the available safety information for oral supplements is limited.

The safety notes in our data advise caution and suggest you clear it with your doctor before starting, especially if you plan to take it long-term. When applied to skin, it's generally well tolerated, though rarely it can cause itching, redness, or minor wound issues.

Eye drops containing hyaluronic acid have rarely caused eye pain at high concentrations.

Side effects, ingredient by ingredient Hyaluronic Acid

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for hyaluronic acid in our data. That doesn't mean none exist—it means they haven't been identified in the evidence we hold.

Check your specific medications with the tool on this page, or confirm with your doctor or pharmacist.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Hyaluronic Acid by Mental Refreshment may be worth considering if you're dealing with dry eye or a venous leg ulcer and your doctor thinks it's a fit. If you're taking any regular medications, check them against the tool on this page or ask your doctor or pharmacist before you start.

Long-term safety data is thin, so this is one to discuss with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hyaluronic Acid, straight from the product label.

Brand Mental Refreshment
Barcode (UPC) 713807375270
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 247851
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hyaluronic Acid by Mental Refreshment, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
713807375270
IngredientAmount% DV
Hyaluronic Acid100 mg--

Other ingredients: Gelatin, Rice powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Premium Brand / Optimum Results

We have assayed & fully guarantee the quality & potency of this product.

100% Satisfaction Guaranteed

Formulation

Supports Healthy Joints Supports Youthful Healthy Skin Skin Hydration & Joint Lubricant

Contains No: Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.

Guaranteed laboratory Tested Quality

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Manufactured in a FDA Registered Facility that conforms to GMP standards GMP Good Manufacturing Practice Consistent Quality Made in the USA

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) capsule daily, preferably with meals.

Precautions

Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Storage

Store in a dry place and avoid excessive heat.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Hyaluronic Acid by Mental Refreshment label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Hyaluronic Acid by Mental Refreshment

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Hyaluronic Acid

No known
interactions
100 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Other (inactive) ingredients: Gelatin, Rice powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hyaluronic Acid by Mental Refreshment Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Hyaluronic Acid. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Hyaluronic Acid, from the product label.

Mental Refreshment

See all Mental Refreshment products
Name
Mental Refreshment Nutrition
Pharmacist Counseling Corner

Hyaluronic Acid by Mental Refreshment: Common Questions

Does Hyaluronic Acid by Mental Refreshment interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Hyaluronic Acid. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Hyaluronic Acid contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take while pregnant or breastfeeding?
The product facts don't include safety information for pregnancy or lactation. There isn't enough data on file to say either way, so this is something to discuss with your doctor or pharmacist—they can give you personalized advice for your situation.
What's hyaluronic acid actually for?
It's a compound that naturally holds water in your skin and tissues. In this product, it's been studied mainly for dry eye and for slow-healing leg sores (venous leg ulcers), where it shows promise. For wrinkles and aging skin, the evidence isn't solid enough yet to say whether it works.
Can it cause side effects?
Taken by mouth, hyaluronic acid is generally well tolerated. When applied to skin, rarely it can cause itching, redness, or minor wound issues. Eye drops with it have rarely caused eye pain. Long-term safety as an oral supplement hasn't been fully studied, so that's worth discussing with your doctor.
Does this product contain any fillers?
Yes—the inactive ingredients are gelatin (the capsule material) and rice powder (a filler). If you have allergies to either, check the label or talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hyaluronic Acid is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hyaluronic Acid label
Go deeper

The Full Monographs Behind Hyaluronic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Hyaluronic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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