Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Immuno Start Ingredients & Drug Interactions

by Mannatech

Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Immuno Start is a dietary supplement by Mannatech with 5 active ingredients. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 316 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta-1,3 / 1,6 Glucans, modified Citrus Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Immuno Start by Mannatech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Immuno Start contains 4 active ingredients. Modified citrus pectin is a soluble fiber thought to help with cholesterol levels.

Lactoferrin is a protein naturally found in milk that may support the body's response to infection and iron status. Beta-1,3/1,6 glucans are compounds from yeast and mushrooms that research suggests may help with cholesterol and heart health.

The product also includes colostrum, which we hold no interaction data for. The tablet also contains inactive ingredients — glucose, natural flavors, stearic acid, malic acid, vegetable magnesium stearate, and silicon dioxide — which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune support and health.
  • We looked for evidence on: Exercise-induced respiratory infections, Lower respiratory tract infections, Respiratory tract infections, Upper respiratory tract infection (URTI), Coronavirus disease 2019 (COVID-19), Otitis media — and 4 related terms.
  • The closest evidence on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Iron deficiency anemia, Gastroenteritis-associated nausea and vomiting, Coronavirus disease 2019 (COVID-19).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea.

Modified citrus pectin is possibly effective for high cholesterol, though the evidence is limited. Beta-1,3/1,6 glucans are likely effective for high cholesterol and coronary heart disease based on clinical research.

The evidence for pectin and beta-glucans in blood sugar control (prediabetes) and radiation exposure is not established in the data we hold. Lactoferrin may be effective for sepsis and pregnancy-related iron deficiency, but research shows it's likely ineffective for preventing serious complications in newborns.

The evidence, ingredient by ingredient Pectin Lactoferrin Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Modified citrus pectin and beta-glucans are generally well tolerated at typical doses, though concentrated supplements haven't been as thoroughly studied as food-source amounts. Common side effects from pectin include mild gas, loose stools, and diarrhea; allergic reactions (including severe ones) are rare but possible, especially in people with oral allergy syndrome.

Lactoferrin is well tolerated at typical doses, though at very high doses (7.2 grams daily) constipation, diarrhea, and fatigue have been reported. For pregnancy, pectin and beta-glucans at supplement doses lack solid safety data — talk with your doctor first.

Lactoferrin safety in pregnancy is not fully established and should only be used under medical supervision. For breastfeeding, concentrated supplement doses of all three ingredients have limited safety data; the facts note that while lactoferrin occurs naturally in breast milk, supplement safety is not well studied.

Side effects, ingredient by ingredient Pectin Lactoferrin Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Pectin, Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 316 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Immuno Start, double-check with your pharmacist if you use lovastatin, tetracycline antibiotics (like doxycycline), or digoxin — pectin may reduce how well these work. Also mention any antihypertensive drugs (blood pressure medications) or immunosuppressants, since beta-glucans may boost their effects or interfere with them.

No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Immuno Start may be worth considering if you're interested in cholesterol and heart support, and you don't take lovastatin, tetracycline antibiotics, digoxin, blood pressure medications, or immunosuppressants. If you take any of those drugs — or any other prescription medication — check with your pharmacist before starting this product.

Pregnant or breastfeeding? Talk to your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immuno Start, straight from the product label.

Brand Mannatech
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34837
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immuno Start by Mannatech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 Gram(s)1%
Sugar1 Gram(s)--
modified Citrus Pectin10 mg--
Lactoferrin10 mg--
Colostrum150 mg--
Beta-1,3 / 1,6 Glucans20 mg--

Other ingredients: Glucose, Natural Flavors, Stearic Acid, Malic Acid, Vegetable Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

IMMUNOSTART

ImmunoStart is a perfect complement to Mannatech’s Optimal Health Plan.*

IMMUNE BALANCING AND SUPPORT FORMULA

Suggested/Recommended/Usage/Directions

Recommended Use: Take one tablet two times daily. Thoroughly chew each tablet before swallowing.

Precautions

Warning: Do not give to children under age 4 unless supervised by an adult due to the risk of choking.

If you are pregnant,nursing, taking medications, have a health condition or are planning a medical procedure, consult your health professional before use.

Discontinue use and consult a doctor if any adverse reaction occurs.

Do not use if inner seal is missing or broken.

Keep out of reach of children.

Contains Milk

Seals/Symbols

M(SM)

Storage

Keep bottle tightly closed. Store in a cool, dry place.

Brand IP Statement(s)

Mannatech and ImmunoStart are trademarks of Mannatech, Incorporated. Beta Right is a registered trademark of Biopolymer Engineering, Incorporated. Prime Colostrum is a registered trademark of ALT-MED Labs, Incorporated. Prime Colostrum is protected by U.S. patents: 6,780,438; 6,475,511; 6,410,058; 6,258,383. Beta Right is protected by U.S. patents: 5,576,015; 5,519,009; 5,397,773; 5,705,184 and 5,702,719. 2014 Mannatech, Incorporated. All rights reserved.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

COLOSTRUM AND GLYCONUTRIENT SUPPLEMENT

Formula

Contains Milk

General

Product Number 12301 US.12301.14.010

See for yourself

Immuno Start by Mannatech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Immuno Start by Mannatech

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Modified Citrus Pectin

Interacts with
23 drugs
10 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Modified Citrus Pectin monograph & interactions

Lactoferrin

No known
interactions
10 mg per serving Form: Milk

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Colostrum

150 mg per serving Form: Bovine Pre-Milk

Beta-1,3 / 1,6 Glucans

Interacts with
293 drugs
20 mg per serving Form: Baker's Yeast Extract

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta-1,3 / 1,6 Glucans monograph & interactions

Other (inactive) ingredients: Glucose, Natural Flavors, Stearic Acid, Malic Acid, Vegetable Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immuno Start by Mannatech Drug Interactions

Want to check YOUR meds against Immuno Start?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
316Drugs
316 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Immuno Start with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta-1,3 / 1,6 Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D

modified Citrus Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Immuno Start, from the product label.

Mannatech

See all Mannatech products
Name
Mannatech, Incorporated
Street Address
600 S. Royal Ln., Ste. 200
City
Coppell
State
TX
ZipCode
75019
Web Address
mannatech.com
Pharmacist Counseling Corner

Immuno Start by Mannatech: Common Questions

Does Immuno Start by Mannatech interact with any medications?
Yes. Based on its ingredients, Immuno Start has a known interaction with 316 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immuno Start contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for cholesterol?
Beta-glucans in this product are likely effective for high cholesterol based on clinical research. Modified citrus pectin is possibly effective, though the evidence is more limited. For blood sugar or radiation exposure, the evidence isn't established in our data.
What are the most common side effects?
From pectin, you might experience gas, loose stools, or mild diarrhea — these are the most frequent issues reported. Lactoferrin at typical doses is generally well tolerated. Allergic reactions to pectin are rare but can happen, especially if you have an oral allergy syndrome.
Can I take this if I'm pregnant?
The safety data for supplement doses during pregnancy is incomplete for all the active ingredients here. Talk with your doctor before starting — they can weigh the potential benefits against what we do and don't know about safety.
Can I take this while breastfeeding?
Concentrated supplement doses haven't been well studied in breastfeeding. Although lactoferrin occurs naturally in breast milk, the safety of taking it as a supplement is not established. Check with your doctor or pharmacist for personalized advice.
Is this product a substitute for my cholesterol medication?
No — this product is not a substitute for prescription cholesterol drugs like lovastatin. In fact, taking this product with those medications could reduce how well they work. Always talk with your doctor before stopping or replacing any prescription medication.
Does this contain any allergens I should know about?
Pectin can trigger allergic reactions in sensitive people, and one case of anaphylaxis has been reported. If you have a history of oral allergy syndrome or citrus sensitivity, be cautious and talk to your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immuno Start is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immuno Start label
Sources

Sources & How We Checked

Immuno Start's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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