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Dietary supplement

Integra-Lean African Mango Irvingia 150 mg Ingredients & Drug Interactions

by Life Extension

Integra-Lean African Mango Irvingia 150 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Integra-Lean African Mango Irvingia 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Integra-Lean African Mango Irvingia 150 mg is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Integra-Lean African Mango Irvingia 150 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Integra-Lean African Mango Irvingia 150 mg by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Integra-Lean African Mango Irvingia 150 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: Integra-Lean African Mango, a proprietary extract of Irvingia gabonensis at 150 mg per capsule. The capsule also holds inactive ingredients—microcrystalline cellulose, vegetable cellulose, vegetable stearate, and silica—which are binders and fillers that hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Irvingia Gabonensis product and its label doesn't state a use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Irvingia gabonensis is not yet well established. We hold insufficient reliable evidence to rate it for diabetes, high cholesterol, obesity, or metabolic syndrome.

While some human research on blood sugar control exists (which is why drug interactions are documented), we don't have enough robust data to say whether it actually works for these conditions in real-world use.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Irvingia gabonensis is generally well tolerated in short-term studies. The most common side effects are flatulence, headache, insomnia, and nausea.

One rare case of acute liver inflammation (hepatitis) has been reported after ten days of use at higher doses; it's unusual, but it signals that long-term safety isn't fully understood. The facts note that long-term safety data and product quality are not well established.

During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, no reliable safety information is available.

If you're pregnant or nursing, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antidiabetes drugs (insulin, metformin, sulfonylureas, and others) or testosterone products. Both can interact at a Moderate level of concern.

Blood glucose monitoring and possible medication adjustments may be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Integra-Lean African Mango may be worth considering if you're interested in weight loss or metabolic support, but the evidence for how well it works isn't solid yet. If you take antidiabetes drugs or testosterone products, you'll need to check with your doctor or pharmacist before starting—blood sugar monitoring and dose changes may be necessary.

Pregnant or breastfeeding? Not enough safety data exists, so discuss it with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Integra-Lean African Mango Irvingia 150 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870129264
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231788
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Integra-Lean African Mango Irvingia 150 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870129264
IngredientAmount% DV
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract150 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule twice daily with or without food, or as recommended by a healthcare practitioner. This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Precautions

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Brand IP Statement(s)

Integra-Lean Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. IGOB-131 proprietary extract is a registered trademark of Gateway Health Alliances, Inc.

Seals/Symbols

Certified Authentic Irvingia Non GMO LE Certified

Formula

Certified Authentic Irvingia

Formulation

Non GMO

Supports weight management and metabolic wellness

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Integra-Lean African Mango Irvingia 150 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Integra-Lean African Mango Irvingia 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Integra-Lean African Mango Irvingia 150 mg by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Interacts with
94 drugs
150 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Integra-Lean African Mango Irvingia 150 mg by Life Extension Drug Interactions

Want to check YOUR meds against Integra-Lean African Mango Irvingia 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract 94

Individual Drug Interactions

The ingredients in Integra-Lean African Mango Irvingia 150 mg interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Integra-Lean African Mango Irvingia 150 mg interact with drugs. Each result below shows which ingredient is responsible. Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Integra-Lean African Mango Irvingia 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Integra-Lean African Mango Irvingia 150 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Integra-Lean African Mango Irvingia 150 mg by Life Extension: Common Questions

Does Integra-Lean African Mango Irvingia 150 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Integra-Lean African Mango Irvingia 150 mg has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Integra-Lean African Mango Irvingia 150 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Irvingia gabonensis and what's it supposed to do?
Irvingia gabonensis is an extract from an African mango plant. It's marketed for weight loss, cholesterol, blood sugar, and metabolic health—but the evidence we have is insufficient to say whether it actually works for any of these.
Can I take this if I'm on diabetes medication?
Not without talking to your doctor first. Irvingia gabonensis can lower blood sugar, and combining it with antidiabetes drugs increases the risk of low blood sugar. Your doctor may need to monitor you closely or adjust your medication dose.
What side effects should I watch for?
The most common are flatulence, headache, insomnia, and nausea. One rare case of liver inflammation has been reported, though it's very uncommon. If you develop jaundice, abdominal pain, or unusual tiredness, stop and contact your doctor.
Is it safe to take if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. While breastfeeding, no reliable information exists either. Talk with your doctor or pharmacist if you're considering it during these times.
Can I take this with testosterone therapy?
Not without checking with your doctor. Animal research suggests Irvingia gabonensis may raise testosterone levels, which could add to the effect of your medication. Your doctor can advise whether it's safe for you.
How long can I safely take this?
Short-term use has been studied and is generally tolerated, but long-term safety isn't well established. The product quality also isn't fully standardized. Discuss how long you plan to use it with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Integra-Lean African Mango Irvingia 150 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Integra-Lean African Mango Irvingia 150 mg label
Go deeper

The Full Monographs Behind Integra-Lean African Mango Irvingia 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Integra-Lean African Mango Irvingia 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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