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Dietary supplement

Iodoral IOD 12.5 Ingredients & Drug Interactions

by Optimox

Iodoral IOD 12.5 label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Iodoral IOD 12.5 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Iodoral IOD 12.5 is a dietary supplement by Optimox with 1 active ingredient. Its ingredients are commonly taken for preventing iodine deficiency, supporting thyroid hormone production, general energy and metabolism support.Based on those ingredients, 7 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Total Iodine/Iodide. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Iodoral IOD 12.5 by Optimox

Ask about any prescription or over-the-counter medication and we check it for interactions with Iodoral IOD 12.5 by Optimox — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Iodoral IOD 12.5 by Optimox

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Total Iodine/Iodide” is listed as a grouped ingredient — the label gives one combined amount (12.50 mg) without saying how much of each component you get.

Iodoral IOD 12.5 contains 2 active ingredients: iodine and iodide, both forms of the same mineral. Together they deliver 12.5 mg of total iodine per tablet.

The product also contains several inactive ingredients — potassium hydroxide, silicon dioxide, magnesium sulfate heptahydrate, polysorbate 80, citric acid, microcrystalline cellulose, vegetable stearins, and pharmaceutical glaze — which are fillers, binders, and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Iodine supplementation for deficiency and thyroid health.
  • We looked for evidence on: Iodine deficiency, Infant development, Prematurity, Radiation exposure, Thyroid function, Metabolic health.
  • The strongest evidence on file: Iodine is rated "Likely Effective" for Radiation exposure (Natural Medicines).
  • Also on file: Iodine is rated "Likely Effective" for Iodine deficiency.
  • Also on file: Iodine is rated "Possibly Ineffective" for Prematurity.

Iodine is likely effective for preventing thyroid problems after radiation exposure and for treating iodine deficiency. The evidence is less established for oral mouth sores (mucositis) and gum disease (periodontitis), where it's rated possibly effective — meaning some evidence exists but it's not yet conclusive.

The evidence, ingredient by ingredient Iodine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Iodine is well tolerated in normal dietary amounts, but high doses can trigger thyroid problems — both overactive and underactive thyroid, goiter (an enlarged thyroid gland), headache, nausea, diarrhea, and a metallic taste in your mouth. In rare cases, people can have a hypersensitivity reaction with symptoms like severe swelling, hives, fever, or bleeding.

Long-term high-dose use has been linked to acnelike skin lesions (iododerma). In pregnancy, adequate iodine is important, but you should use only the amount your doctor advises and avoid high-dose products like this one.

During breastfeeding, some iodine passes into breast milk, so follow your doctor's guidance. If you have a known true iodine hypersensitivity (not just a shellfish or contrast-dye allergy), talk with your pharmacist before starting.

Side effects, ingredient by ingredient Iodine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Iodine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 7 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Iodoral IOD 12.5, check if you're on lithium (a mood stabilizer), any antithyroid drugs like propylthiouracil or methimazole, or amiodarone (a heart rhythm medication) — all have Moderate interactions with iodine. If you're on any of these, your doctor or pharmacist needs to know before you start this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a high-dose iodine product meant for specific medical situations — radiation protection or diagnosed deficiency — not everyday supplementation. If you take lithium, antithyroid drugs, or amiodarone, you need to check with your pharmacist or doctor before starting.

Anyone else should confirm their medications don't interact using the tool below.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Iodoral IOD 12.5, straight from the product label.

Brand Optimox
Barcode (UPC) 350520015016
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 317597
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Iodoral IOD 12.5 by Optimox, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
350520015016
IngredientAmount% DV
Iodine5 mg--
Total Iodine/Iodide12.5 mg8333%
Iodide7.5 mg--

Other ingredients: Potassium Hydroxide, Silicon Dioxide, Magnesium Sulfate Heptahydrate, Polysorbate 80, Citric Acid, Microcrystalline Cellulose, Vegetable Stearins, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

An iodine/potassium iodine formula that supplies 12.5 mg of elemental iodine per tablet.

Iodine/Potassium iodide

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one tablet per day or as directed by a physician.

Precautions

Warning: If pregnant or nursing, consult your healthcare practitioner before use. Do not use if you have an iodine sensitivity, or if you are taking anti-hypertension or anti-thyroid medications.

Keep out of reach of children.

Discontinue use if you develop swollen salivary glands, stomach upset, or skin rash.

Storage

Store in a cool, dry and dark place.

Formulation

High potency

Variations in product color may occur.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Iodoral IOD 12.5 by Optimox label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Iodoral IOD 12.5 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Iodoral IOD 12.5 by Optimox

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Total Iodine/Iodide

Interacts with
7 drugs
12.5 mg per serving

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...

Total Iodine/Iodide monograph & interactions

Other (inactive) ingredients: Potassium Hydroxide, Silicon Dioxide, Magnesium Sulfate Heptahydrate, Polysorbate 80, Citric Acid, Microcrystalline Cellulose, Vegetable Stearins, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Iodoral IOD 12.5 by Optimox Drug Interactions

Want to check YOUR meds against Iodoral IOD 12.5?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
7Drugs
7 Moderate

Ingredients driving the most interactions

Total Iodine/Iodide 7

Individual Drug Interactions

The ingredients in Iodoral IOD 12.5 interact with 7 drugs. Click any drug to see the details.

1 of the 1 ingredient in Iodoral IOD 12.5 interact with drugs. Each result below shows which ingredient is responsible. Total Iodine/Iodide

Each ingredient & the kinds of drugs it affects

For each ingredient in Iodoral IOD 12.5 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Total Iodine/Iodide3 drug types · 7 drugs

Amiodarone (Cordarone)

Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.

Likelihood Probable Evidence D
Antithyroid Drugs

Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.

Likelihood Probable Evidence D
Lithium

Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.

Likelihood Probable Evidence D
Total Iodine/Iodide full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Iodoral IOD 12.5, from the product label.

Optimox

See all Optimox products
Name
Allergy Research Group
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800-545-9960
Web Address
www.allergyresearch.com
Pharmacist Counseling Corner

Iodoral IOD 12.5 by Optimox: Common Questions

Does Iodoral IOD 12.5 by Optimox interact with any medications?
Yes. Based on its ingredients, Iodoral IOD 12.5 has a known interaction with 7 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Iodoral IOD 12.5 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Iodoral IOD 12.5 safe to take during pregnancy?
The safety data is mixed. Adequate iodine is important for you and your baby's thyroid health, but this is a high-dose product. Use only the amount your doctor advises and avoid high-dose iodine products unless medically directed. Talk with your doctor or pharmacist about what's right for your situation.
Can I take this while breastfeeding?
Your baby does need some iodine through breast milk, but excess iodine will pass through. Follow your doctor's guidance on dosing — don't take more than advised. Your pharmacist or doctor can help you figure out what's safe for your nursing baby.
What are the most common side effects?
Stomach upset, diarrhea, nausea, headache, and a metallic taste in your mouth are the most common. Long-term or very high-dose use can cause thyroid problems or acnelike skin lesions. Most people tolerate normal dietary amounts well, but this product is a higher dose.
Does Iodoral IOD 12.5 actually work for iodine deficiency?
Yes — iodine is rated likely effective for treating iodine deficiency. It's also likely effective for protecting your thyroid after radiation exposure. For mouth sores and gum disease, the evidence is less clear, so it's only possibly effective.
Can I take this if I have a shellfish allergy?
A shellfish allergy is usually a reaction to shellfish proteins, not iodine itself. This product is a synthetic iodine supplement, so a shellfish allergy shouldn't automatically rule it out — but if you've had a reaction labeled 'iodine allergy' before, talk with your pharmacist to figure out what you actually reacted to.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Iodoral IOD 12.5 label
Go deeper

The Full Monographs Behind Iodoral IOD 12.5’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Iodine

Interacts with 7 drugs

Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...

Read the full Iodine monograph →
Sources

Sources & How We Checked

Iodoral IOD 12.5's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Iodine 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
  3. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993;36:453-60.
  4. Potassium iodide for nuclear exposure. Pharmacist's Letter/Prescriber's Letter 2001;17(12):171214.
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cabezas C, Bustamante B, Holgado W, Begue RE. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatr Infect Dis J 1996;15:352-4. PubMed
  7. Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
  8. Yarrington CD, Pearce EN. Dietary iodine in pregnancy and postpartum. Clin Obstet Gynecol 2011;54:459-70. PubMed
  9. Goel, S., Mandhani, A., Srivastava, A., Kapoor, R., Gogoi, S., Kumar, A., and Bhandari, M. Is povidone iodine an alternative to silver nitrate for renal pelvic instillation sclerotherapy in chyluria? BJU.Int 2004;94(7):1082-1085. PubMed
  10. Teng, W., Shan, Z., Teng, X., Guan, H., Li, Y., Teng, D., Jin, Y., Yu, X., Fan, C., Chong, W., Yang, F., Dai, H., Yu, Y., Li, J., Chen, Y., Zhao, D., Shi, X., Hu, F., Mao, J., Gu, X., Yang, R., Tong, Y., Wang, W., Gao, T., and Li, C. Effect of iodine int
  11. Crawford, B. A., Cowell, C. T., Emder, P. J., Learoyd, D. L., Chua, E. L., Sinn, J., and Jack, M. M. Iodine toxicity from soy milk and seaweed ingestion is associated with serious thyroid dysfunction. Med J Aust. 10-4-2010;193(7):413-415. PubMed
  12. Ohkuma, M. Molluscum contagiosum treated with iodine solution and salicylic acid plaster. Int J Dermatol. 1990;29(6):443-445. PubMed
  13. Connelly KJ, Boston BA, Pearce EN, Sesser D, Snyder D, Braverman LE, Pino S, LaFranchi SH. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr. 2012 Oct;161(4):760-2. PubMed
  14. Kasahara T, Narumi S, Okasora K, Takaya R, Tamai H, Hasegawa T. Delayed onset congenital hypothyroidism in a patient with DUOX2 mutations and maternal iodine excess. Am J Med Genet A. 2013 Jan;161A(1):214-7.
  15. Murcia M, Rebagliato M, Iñiguez C, Lopez-Espinosa MJ, Estarlich M, Plaza B, Barona-Vilar C, Espada M, Vioque J, Ballester F. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. Am J Epidemiol. 2011 Apr 1;173(7):8 PubMed
  16. Sang Z, Wang PP, Yao Z, Shen J, Halfyard B, Tan L, Zhao N, Wu Y, Gao S, Tan J, Liu J, Chen Z, Zhang W. Exploration of the safe upper level of iodine intake in euthyroid Chinese adults: a randomized double-blind trial. Am J Clin Nutr. 2012 Feb;95(2):367-73 PubMed
  17. Speeckaert MM, Speeckaert R, Wierckx K, Delanghe JR, Kaufman JM. Value and pitfalls in iodine fortification and supplementation in the 21st century. Br J Nutr. 2011 Oct;106(7):964-73. PubMed
  18. Yun SE, Kang Y, Bae EJ, Hwang K, Jang HN, Cho HS, Chang SH, Park DJ. Iodine-induced thyrotoxic hypokalemic paralysis after ingestion of Salicornia herbace. Ren Fail. 2014 Apr;36(3):461-3.
  19. Iodine Hypersensitivity. Pharmacist's Letter/Prescriber's Letter 2011; 27(5):270504.
  20. Hammel JA, Selby JC. Pustular eruption in a patient with cancer treated with complementary and alternative medicine. JAMA Dermatology 2017 October; E1. doi: 10.1001/jamadermatol.2017.3749. [Epub ahead of print] PubMed
  21. Gil GS, Smith BW, Guerra JR, Williams WT. Acute Delirium in a Hypothyroid Patient Precipitated by Iodine Supplements Use. Am J Ther. 2018;25(6):e717-e718. PubMed
  22. Hamby T, Kunnel N, Dallas JS, Wilson DP. Maternal iodine excess: an uncommon cause of acquired neonatal hypothyroidism. J Pediatr Endocrinol Metab. 2018;31(9):1061-1064. PubMed
  23. Censi S, Watutantrige-Fernando S, Groccia G, et al. The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine
  24. Rovner MS, Wolf BJ, Rubin M, et al. Instillation of 5% Povidone-Iodine Ophthalmic Drops Decreases the Respiratory Rate in Children Undergoing Strabismus Surgery: A Randomized Controlled Trial. J Pediatr Ophthalmol Strabismus. 2019;56(6):378-382. PubMed
  25. Guenezan J, Garcia M, Strasters D, et al. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2021;147(4):400-401. PubMed
  26. Li F, Wan S, Zhang L, et al. A Meta-Analysis of the Effect of Iodine Excess on the Intellectual Development of Children in Areas with High Iodine Levels in their Drinking Water. Biol Trace Elem Res 2022;200(4):1580-1590. PubMed

See these in context on the Iodine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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