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Dietary supplement

IonMin Clay Ingredients & Drug Interactions

by Professional Botanicals

IonMin Clay label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking IonMin Clay against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

IonMin Clay is a dietary supplement by Professional Botanicals with 1 active ingredient. Its ingredients are commonly taken for detox and digestive complaints, skin care (masks, acne, irritation), diarrhea and upset stomach.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ion Mineral Clay. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against IonMin Clay by Professional Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with IonMin Clay by Professional Botanicals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of IonMin Clay by Professional Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

IonMin Clay is a single-ingredient powder: ion mineral clay. This is the active component — no other active ingredients are included.

The product contains no additional inactive fillers or excipients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: expel toxins and support digestive health.
  • We looked for evidence on: Irritable bowel syndrome (IBS), Chemotherapy-induced diarrhea, Rotaviral diarrhea, Stomach ulcers, Gastrointestinal inflammation, Digestive support.
  • The strongest evidence on file: Clay is rated "Possibly Effective" for Rotaviral diarrhea (Natural Medicines).
  • Also on file: Clay is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Irritable bowel syndrome (IBS).

The evidence for clay's effectiveness depends on what you're using it for. For rotaviral diarrhea (the watery diarrhea caused by rotavirus, especially in children), the data shows it's possibly effective.

For chemotherapy-induced diarrhea and irritable bowel syndrome (IBS), there isn't enough reliable evidence to establish whether it works. The data we hold doesn't support a clear effectiveness rating for those uses.

The evidence, ingredient by ingredient Clay

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth short-term, clay is generally well tolerated, though some people experience mild constipation, vomiting, or diarrhea. The bigger concern is with long-term or habitual use.

Heavy metals can contaminate oral clay, and swallowing clay regularly has been linked to iron deficiency anemia, heart problems (including heart lesions, enlarged heart muscle, and painful palpitations), muscle weakness from low potassium, and nerve damage from lead exposure. The safety data advises against taking clay by mouth during pregnancy due to heavy-metal and nutrient-absorption risks, and advises against it while breastfeeding because there isn't enough data to know if it's safe.

Side effects, ingredient by ingredient Clay

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Clay.
  • The most serious interaction on file is rated Moderate.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use cimetidine (Tagamet) for heartburn or quinine for malaria or leg cramps. Clay can reduce how much of these medications your body absorbs and may lower their effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with rotaviral diarrhea, but the evidence for other uses like IBS is incomplete. It interacts with cimetidine and quinine, so check your medications first.

More importantly, long-term use carries real risks — heavy-metal contamination, anemia, and heart and nerve damage — so this is best used short-term and under guidance. Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about IonMin Clay, straight from the product label.

Brand Professional Botanicals
Barcode (UPC) 898175001171
Net contents 250 Gram(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 274314
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for IonMin Clay by Professional Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 NP
Maximum serving Sizes:
0 NP
UPC/BARCODE
898175001171
IngredientAmount% DV
Ion Mineral Clay0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Ion Mineral Clay helps expel toxins, increase immunity and reduce inflammation. The clay has many uses, topically for burns or as a facial treatment, and internally for supporting stomach ulcers and pain. This clay also promotes a nutrient-rich diet for overall health.

Gluten free Non GMO No fillers

Premium quality

3x Tested

Suggested/Recommended/Usage/Directions

Directions: Internally: Mix 3-1 parts liquid and clay and drink twice per day or as directed. Topically: Mix 1-1 parts warm water and clay. Stir well to make a smooth paste. Apply as needed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

General Statements

2 Please recycle

EST. 1980

Formula

Mineral Clay Powder

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

IonMin Clay by Professional Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

IonMin Clay label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in IonMin Clay by Professional Botanicals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0 NP Dosage formPowder Amounts shown are per serving.

Ion Mineral Clay

Interacts with
3 drugs
0 NP per serving

Clay is a fine, mineral-rich earth (such as bentonite or kaolin) used on the skin and sometimes taken by mouth for digestive and 'detox' purposes. Top...

Ion Mineral Clay monograph & interactions
Interaction report

IonMin Clay by Professional Botanicals Drug Interactions

Want to check YOUR meds against IonMin Clay?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Moderate

Ingredients driving the most interactions

Ion Mineral Clay 3

Individual Drug Interactions

The ingredients in IonMin Clay interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in IonMin Clay interact with drugs. Each result below shows which ingredient is responsible. Ion Mineral Clay

Each ingredient & the kinds of drugs it affects

For each ingredient in IonMin Clay with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ion Mineral Clay2 drug types · 3 drugs

Cimetidine (Tagamet)

Preliminary clinical research suggests that clay might inhibit the absorption of cimetidine when taken simultaneously. Consumption of clay along with cimetidine might reduce the effectiveness of cimetidine therapy.

Likelihood Possible Evidence B
Quinine

In vitro evidence suggests that consuming clay reduces the bioavailability of quinine by about 30%. Theoretically, consumption of clay along with quinine might reduce the effectiveness of quinine therapy.

Likelihood Probable Evidence D
Ion Mineral Clay full monograph & interactions
The maker

Brand information

Manufacturer and brand details for IonMin Clay, from the product label.

Professional Botanicals

See all Professional Botanicals products
Name
Professional Botanicals
City
Ogden
State
UT
ZipCode
84404
Phone Number
877-745-0850
Web Address
ProfessionalBotanicals.com
Pharmacist Counseling Corner

IonMin Clay by Professional Botanicals: Common Questions

Does IonMin Clay by Professional Botanicals interact with any medications?
Yes. Based on its ingredients, IonMin Clay has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
IonMin Clay contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The safety data advises against it. Clay can be contaminated with heavy metals, and swallowing it may interfere with how your body absorbs nutrients — both concerns during pregnancy. Talk with your doctor or pharmacist for personalized advice.
What about breastfeeding?
There isn't enough safety data to know either way. The data recommends avoiding it while breastfeeding. Discuss it with your doctor or pharmacist to decide what's right for you.
How long is it safe to use this?
Short-term use is generally well tolerated. Long-term or habitual clay intake has been linked to serious problems — anemia, heart issues, and nerve damage — so it's best used for brief periods and under guidance from your pharmacist or doctor.
What does this product actually treat?
The evidence shows it's possibly effective for rotaviral diarrhea. For other uses like irritable bowel syndrome or diarrhea from chemotherapy, there isn't enough reliable evidence to say whether it works.
What are the side effects?
Short-term, side effects tend to be mild — constipation, vomiting, or diarrhea. Long-term use is where the real risk lies: habitual intake can cause iron-deficiency anemia, heart problems, muscle weakness, and lead poisoning.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if IonMin Clay is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

IonMin Clay label
Go deeper

The Full Monographs Behind IonMin Clay’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Clay

Interacts with 3 drugs

Clay is a fine, mineral-rich earth (such as bentonite or kaolin) used on the skin and sometimes taken by mouth for digestive and 'detox' purposes. Topical use for masks and minor skin issues...

Read the full Clay monograph →
Sources

Sources & How We Checked

IonMin Clay's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Clay 31 references
  1. Gonzalez JJ, Owens W, Ungaro PC, et al. Clay ingestion: a rare cause of hypokalemia. Ann Intern Med 1982;97(1):65-6. PubMed
  2. Mengel CE, Carter WA, Horton ES. Geophagia with iron deficiency and hypokalemia. Cachexia Africana. Arch Intern Med 1964;114:470-4. PubMed
  3. Severance HW Jr, Holt T, Patrone NA, Chapman L. Profound muscle weakness and hypokalemia due to clay ingestion. South Med J 1988;81(2):272-4. PubMed
  4. Minnich V, Okcuoglu A, Tarcon Y, et al. Pica in Turkey. II. Effect of clay upon iron absorption. Am J Clin Nutr 1968;21(1):78-86.
  5. O'Rourke DE, Quinn JG, Nicholson JO, Gibson HH. Geophagia during pregnancy. Obstet Gynecol 1967;29(4):581-4.
  6. Edwards CE, McDonald S, Mitchell JK, et al. Effect of clay and cornstarch intake on women and their infants. J Amer Diet Assoc 1964;44:109-15. DOI
  7. Carpenter WM. Observations on Cachexia Africana, on habits and effects of dirt eating in negro race. New Orleans Med Surg J 1844;1:146-68.
  8. Ducrotte P, Dapoigny M, Bonaz B, Siproudhis L. Symptomatic efficacy of beidellitic montmorillonite in irritable bowel syndrome: a randomized, controlled trial. Aliment Pharmacol Ther 2005;21(4):435-44. PubMed
  9. Chang FY, Lu CL, Chen CY, Luo JC. Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome. J Gastroenterol Hepatol 2007;22(12):2266-72. PubMed
  10. Blum M, Orton C, Rose L. The effect of starch ingestion on excessive iron association, abstracted. Ann Intern Med 1968;68:1165.
  11. Ukaonu C, Hill DA, Christensen F. Hypokalemic myopathy in pregnancy caused by clay ingestion. Obstet Gynecol 2003;102(5 Pt 2):1169-71. DOI
  12. Andrews PL, Horn CC. Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Auton Neurosci 2006;125(1-2):100-15. PubMed
  13. Wang JS, Luo H, Billam M, et al. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Addit Contam 2005;22(3):270-9. PubMed
  14. Bateson EM, Lebroy T. Clay eating by Aboriginals of the Northern Territory. Med J Aust 1978;1 Suppl 1:1-3. PubMed
  15. Delaitre B, Lemaigre G, Acar JF, et al. [Necrotizing enteritis and geophagia]. Nouv Presse Med 1976;5(28):1743-6.
  16. Sanchez A JE. Perforation of the colon due to clay ball. Arch Surg 1978;113(7):906. PubMed
  17. Prasad AS, Halsted JA, Nadimi M. Syndrome of iron deficiency anemia, hepatospelenomegaly, hypogonadism, dwarfism and geophagia. Am J Med 1961;31:532-46.
  18. Bennett A, Stryjewski G. Severe hypokalemia caused by oral and rectal administration of bentonite in a pediatric patient. Pediatr Emerg Care 2006;22(7):500-2. PubMed
  19. Guinee VF. Pica and lead poisoning. Nutr Rev 1971;29(12):267-9. PubMed
  20. Getahun H, Lambein F, Vanhoorne M, Van der Stuyft P. Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidants. Trop Med Int Health 2005;10(2):169-78. PubMed
  21. Trivedi TH, Daga GL, Yeolekar ME. Geophagia leading to hypokalemic quadriparesis in a postpartum patient. J Assoc Physicians India 2005;53:205-7.
  22. Fredj G, Farinotti R, Salvadori C, et al. [Topical digestive drugs with a clay base. Influence on the absorption of cimetidine]. Therapie 1986;41(1):23-5.
  23. Dominy NJ, Davoust E, Minekus M. Adaptive function of soil consumption: an in vitro study modeling the human stomach and small intestine. J Exp Biol 2004;207(Pt 2):319-24.
  24. Pariente EA, De La Garoullaye G. A multicenter comparative study of a mucilage (Karaya gum + PVPP) versus clay in functional intestinal disorders. Med Chir Dig 1994;23(3):193-9.
  25. Pérez-Gaxiola G, Cuello-García CA, Florez ID, Pérez-Pico VM. Smectite for acute infectious diarrhoea in children. Cochrane Database Syst Rev. 2018;4:CD011526. PubMed
  26. Kee BK, Morris JS, Slack RS, et al. A phase II, randomized, double blind trial of calcium aluminosilicate clay versus placebo for the prevention of diarrhea in patients with metastatic colorectal cancer treated with irinotecan. Support Care Cancer. 2015;2 PubMed
  27. Mitchell NJ, Kumi J, Aleser M, et al. Short-term safety and efficacy of calcium montmorillonite clay (UPSN) in children. Am J Trop Med Hyg. 2014;91(4):777-85. PubMed
  28. Gupta M, Sachdev A, Lehl SS, Singh K. Clay impaction causing acute dysphagia. BMJ Case Rep. 2013;2013. pii: bcr2013008929. PubMed
  29. Lin JX, Fan ZY, Lin Q, et al. A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: a pilot study. Eur J Oncol Nurs. 2015;19(2):136-41. PubMed
  30. Lai BY, Liang N, Cao HJ, et al. Pediatric Tui Na for acute diarrhea in children under 5 years old: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2018;41:10-22. PubMed
  31. Schmidt C, Oxley Oxland J, Freercks R. A rare case of hypokalaemia and hypophosphataemia secondary to geophagia. BMJ Case Rep. 2021 May 12;14(5):e239322. PubMed

See these in context on the Clay monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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