Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Kidney Support Ingredients & Drug Interactions

by Professional Botanicals

Kidney Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kidney Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kidney Support is a dietary supplement by Professional Botanicals with 7 active ingredients. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 2,258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Plantain, Fenugreek, Horsetail. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Kidney Support by Professional Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Kidney Support by Professional Botanicals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Kidney Support by Professional Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 15 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (838 mg) without saying how much of each component you get.
  • “AdPT” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “EDS” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Kidney Support contains 15 ingredients total, organized partly as proprietary blends (Proprietary Blend, AdPT, and EDS) and partly as individual active ingredients: the enzymes protease, lipase, amylase, and cellulase; the adaptogenic herbs ashwagandha, rhodiola, eleuthero, cordyceps, reishi mushroom, and gynostemma; and the botanical extracts fenugreek, hydrangea, horsetail, and plantain, plus European goldenrod. These are supported by inactive ingredients—rice flour, cellulose, and water—that serve as fillers and binders in the capsule.

The enzyme ingredients (protease, lipase, amylase, cellulase) are meant to support digestion. The herbal actives—ashwagandha, rhodiola, eleuthero, cordyceps, and reishi—are adaptogens traditionally used to support the body's stress response and energy.

Fenugreek, gynostemma, horsetail, hydrangea, and plantain round out the formula with their own traditional kidney and urinary support roles.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support circulation, detoxification and kidney function.
  • We looked for evidence on: Chronic kidney disease (CKD), Diabetic nephropathy, Contrast induced nephropathy, kidney health, renal support, urinary function.
  • The closest evidence on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Diabetic nephropathy (Natural Medicines).
  • Also on file: Cordyceps is rated "Insufficient Reliable Evidence To Rate" for Contrast induced nephropathy, Chronic kidney disease (CKD).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chronic kidney disease (CKD).

The evidence on effectiveness is mixed and limited across most ingredients in this formula. Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder.

Fenugreek is possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea, and diabetes. Cordyceps appears possibly ineffective for athletic performance but carries insufficient evidence for sexual dysfunction, heart rhythm, asthma, and lung health.

Eleuthero is possibly effective for genital herpes, while reishi mushroom is possibly ineffective for cholesterol levels. Gynostemma is possibly effective for diabetes but has insufficient evidence for athletic performance, cancer, heart disease, and liver health.

For lipase and protease enzymes, the data shows insufficient evidence to establish effectiveness for inflammation and digestive conditions. For rhodiola, horsetail, hydrangea, cordyceps, reishi, eleuthero, and gynostemma in other uses, evidence is also insufficient.

We hold no effectiveness data for amylase, cellulase, plantain, or European goldenrod.

The evidence, ingredient by ingredient Fenugreek Black Psyllium Hydrangea Horsetail

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 12 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated for short-term use in healthy adults, though quality and long-term safety data are often limited. The enzymes protease and lipase may cause digestive upset or allergic reactions (protease particularly in those with documented sensitivity).

Ashwagandha has been linked to rare cases of acute liver damage and hepatitis; case reports also describe reversible cerebral vasoconstriction and intracranial bleeding, though causality is unclear. Fenugreek carries a rare risk of severe allergic reactions including anaphylaxis.

Eleuthero may raise blood pressure and cause nervousness at higher doses. Cordyceps has one case report of cholestatic hepatitis (liver inflammation), though a contaminant cannot be ruled out.

During pregnancy, the safety data advises against ashwagandha (traditionally thought to risk miscarriage), fenugreek (medicinal amounts may affect the uterus), rhodiola, cordyceps, reishi, eleuthero, and horsetail—all lack sufficient data. Gynostemma's data specifically state to avoid it because safety is unestablished.

Hydrangea also advises avoidance in pregnancy. During breastfeeding, safety is inadequate for ashwagandha, fenugreek (though some use it to support milk supply), rhodiola, cordyceps, reishi, eleuthero, horsetail, and hydrangea; for lipase and protease, discuss with your provider first given limited data.

We hold no pregnancy or breastfeeding data for amylase, cellulase, plantain, or European goldenrod.

Side effects, ingredient by ingredient Fenugreek Black Psyllium Hydrangea Horsetail

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 10 of the 12 matched ingredients can interact with medications — Black Psyllium, Jiaogulan, Cordyceps, Hydrangea, Fenugreek, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Kidney Support, check your medications against these drug types, starting with the most serious: CNS depressants and benzodiazepines (from ashwagandha), blood pressure medications (ashwagandha, rhodiola, reishi, eleuthero), blood thinners and antiplatelet drugs (fenugreek, cordyceps, reishi, gynostemma, eleuthero, horsetail), diabetes medications (ashwagandha, rhodiola, cordyceps, reishi, gynostemma, eleuthero, fenugreek, horsetail), immunosuppressants (ashwagandha, rhodiola, cordyceps, gynostemma, eleuthero), hepatotoxic (liver-damaging) medications (ashwagandha), diuretics (horsetail), lithium (hydrangea, horsetail), antiretroviral therapy (horsetail), and seizure or heart medications like phenytoin and digoxin (fenugreek). Use the medication search tool on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Kidney Support combines enzymes and adaptogenic herbs, but it carries real interaction risks with common medications—especially blood pressure drugs, diabetes medications, blood thinners, and immunosuppressants. If you take any prescription medications, seizure drugs, heart medications, lithium, or antiretrovirals, run this product through the medication checker or talk to your pharmacist before starting.

Short-term use by healthy adults with no medications is generally well tolerated, though long-term safety is not established for most ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kidney Support, straight from the product label.

Brand Professional Botanicals
Barcode (UPC) 898175001423
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 308989
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kidney Support by Professional Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
898175001423
IngredientAmount% DV
Proprietary Blend838 mg--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Ashwagandha0 NP--
Rhodiola0 NP--
AdPT0 NP--
Cordyceps0 NP--
Reishi0 NP--
Gynostemma0 NP--
EDS0 NP--
Eleuthero0 NP--
Fenugreek0 NP--
Plantain0 NP--
Hydrangea0 NP--
Horsetail0 NP--
European Goldenrod0 NP--

Other ingredients: Rice Flour, Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Designed to support circulation, detoxification and overall function of kidneys.

Gluten free Non-GMO Verified No fillers 3x tested

Premium quality

Suggested/Recommended/Usage/Directions

Dosage: One to two capsules three times a day, or as directed.

Formula

EDS: Added enzymes for better absorption & breakdown. AdPT: Adaptogenic herbs for energy production & adaptation.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

General Statements

2 Please recycle

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Professional Botanicals Est. 1980

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kidney Support by Professional Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kidney Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kidney Support by Professional Botanicals

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

838 mg per serving

Other (inactive) ingredients: Rice Flour, Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kidney Support by Professional Botanicals Drug Interactions

Want to check YOUR meds against Kidney Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,258Drugs
1,193 Moderate 1,065 Minor

Ingredients driving the most interactions

Plantain 2,025
Fenugreek 389
Horsetail 188
Hydrangea 1

Individual Drug Interactions

The ingredients in Kidney Support interact with 2,258 drugs. Click any drug to see the details.

4 of the 7 ingredients in Kidney Support interact with drugs. Each result below shows which ingredient is responsible. Plantain Fenugreek Horsetail Hydrangea

Each ingredient & the kinds of drugs it affects

For each ingredient in Kidney Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Plantain7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Plantain full monograph & interactions

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions

Horsetail5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail full monograph & interactions

Hydrangea1 drug type · 1 drug

Lithium

Hydrangea is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, hydrangea might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Hydrangea full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kidney Support, from the product label.

Professional Botanicals

See all Professional Botanicals products
Name
Professional Botanicals
City
Ogden
State
UT
ZipCode
84404
Phone Number
877-745-0850
Web Address
ProfessionalBotanicals.com
Pharmacist Counseling Corner

Kidney Support by Professional Botanicals: Common Questions

Does Kidney Support by Professional Botanicals interact with any medications?
Yes. Based on its ingredients, Kidney Support has a known interaction with 2,258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kidney Support contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Kidney Support if I'm on blood pressure medication?
No—not without checking first. Ashwagandha, rhodiola, reishi, and eleuthero in this formula all have Moderate interactions with blood pressure drugs and may increase the risk of dangerously low blood pressure. Talk to your pharmacist or doctor before starting.
Is ashwagandha in this product safe long-term?
The safety data show it's generally well tolerated short-term in healthy adults, but long-term safety is not well studied. Additionally, rare case reports link ashwagandha to liver damage and other serious effects. It's not something to take indefinitely without medical oversight.
Can I use this if I'm pregnant?
No. Ashwagandha is traditionally thought to risk miscarriage and is advised against. Fenugreek, medicinal amounts may affect the uterus. Several other ingredients—rhodiola, cordyceps, reishi, eleuthero, horsetail, hydrangea, and gynostemma—lack sufficient safety data in pregnancy. Talk to your doctor first.
Does this product help with kidney health?
We have no effectiveness data on file for most of the kidney-support herbs in this formula. The enzymes (protease, lipase) have insufficient evidence to establish whether they work for kidney or digestive support. Your pharmacist or doctor can advise on whether this is appropriate for your specific situation.
What should I do if I'm taking a diabetes medication?
Check with your pharmacist before starting. Ashwagandha, rhodiola, fenugreek, horsetail, cordyceps, reishi, and gynostemma all interact with blood sugar control and may increase the risk of low blood sugar (hypoglycemia). Your dose may need adjustment.
Are there any ingredients you couldn't check for interactions?
Yes. We hold no interaction data for amylase, cellulase, plantain, or European goldenrod. The Proprietary Blend, AdPT, and EDS blends are broken down into their component ingredients above, so you can check those.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kidney Support label
Go deeper

The Full Monographs Behind Kidney Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Hydrangea

Interacts with 1 drug

Hydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Beca...

Read the full Hydrangea monograph → Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph →
Sources

Sources & How We Checked

Kidney Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 175 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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Reishi Mushroom 17 references
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Eleuthero 24 references
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Black Psyllium 18 references
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Hydrangea 1 reference
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See these in context on the Hydrangea monograph →

Horsetail 14 references
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See these in context on the Horsetail monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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