Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Ipriflavone 600 mg Ingredients & Drug Interactions

by Vital Nutrients

Ipriflavone 600 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ipriflavone 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ipriflavone 600 mg is a dietary supplement by Vital Nutrients with 1 active ingredient. Its ingredients are commonly taken for bone density and osteoporosis, postmenopausal bone loss, athletic performance.Based on those ingredients, 391 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ipriflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ipriflavone 600 mg by Vital Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with Ipriflavone 600 mg by Vital Nutrients — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ipriflavone 600 mg by Vital Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: ipriflavone 600 mg per capsule. Ipriflavone is a plant-derived compound used to support bone density and strength.

The capsule also holds inactive ingredients — cellulose, ascorbic acid, rice powder, ascorbyl palmitate, and silica — which serve as fillers, binders, and stabilizers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone density and osteoporosis support.
  • We looked for evidence on: Osteoporosis, Postmenopausal bone loss, Bone health.
  • The strongest evidence on file: Ipriflavone is rated "Likely Effective" for Osteoporosis (Natural Medicines).

Ipriflavone is likely effective for osteoporosis and Paget disease (a bone disorder that causes abnormal bone growth). The evidence supporting these uses comes from clinical research, though as with any supplement, real-world results can vary by person.

The evidence, ingredient by ingredient Ipriflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ipriflavone is generally well tolerated when taken by mouth, but some people experience stomach pain, diarrhea, or dizziness. There's also concern that long-term use — at least 6 months or longer — can lower white blood cell counts, so caution is warranted with extended use.

The safety data during pregnancy is not sufficient to recommend use, and there isn't reliable safety information for breastfeeding, so those who are pregnant or nursing should avoid this product and talk with their doctor or pharmacist about alternatives.

Side effects, ingredient by ingredient Ipriflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ipriflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 391 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take theophylline (for breathing problems) — ipriflavone can raise its levels and cause toxicity. You should also double-check if you're on antidepressants, anti-anxiety drugs, muscle relaxers, blood thinners, or any immunosuppressant medication, since ipriflavone can raise levels of drugs processed through certain liver pathways and may amplify immune suppression.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ipriflavone may be worth considering if you have osteoporosis or Paget disease and your doctor thinks it's appropriate for you. However, because it interacts with a large number of medications and can lower white blood cells with long-term use, it's not right for everyone.

Before starting, check your medications with your own doctor or pharmacist, especially if you take theophylline, immunosuppressants, or any drugs metabolized by your liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ipriflavone 600 mg, straight from the product label.

Brand Vital Nutrients
Barcode (UPC) 693465415115
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305056
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ipriflavone 600 mg by Vital Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
693465415115
IngredientAmount% DV
Ipriflavone600 mg--

Other ingredients: Cellulose, Ascorbic Acid, Rice, Powder, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store sealed in a cool dry place

Precautions

Keep out of reach of children

Use only if safety seal is intact

Warning If pregnant, consult your physician before taking.

Suggested/Recommended/Usage/Directions

Recommendations Take 2 capsules daily, or as directed by your healthcare professional.

Formulation

Excludes coatings, binders, gluten (wheat, rye, barley), milk/dairy (casein, whey), soy protein, egg protein, sugar. Verified by independent testing

Raw materials and finished products are independently tested by U.S. labs.

General Statements

Learn more at vitalnutrients.net

FDA Statement of Identity

Dietary supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ipriflavone 600 mg by Vital Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ipriflavone 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ipriflavone 600 mg by Vital Nutrients

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Ipriflavone

Interacts with
391 drugs
600 mg per serving Form: 7-Isopropoxyisoflavone

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...

Ipriflavone monograph & interactions

Other (inactive) ingredients: Cellulose, Ascorbic Acid, Rice, Powder, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ipriflavone 600 mg by Vital Nutrients Drug Interactions

Want to check YOUR meds against Ipriflavone 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
391Drugs
391 Moderate

Ingredients driving the most interactions

Ipriflavone 391

Individual Drug Interactions

The ingredients in Ipriflavone 600 mg interact with 391 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ipriflavone 600 mg interact with drugs. Each result below shows which ingredient is responsible. Ipriflavone

Each ingredient & the kinds of drugs it affects

For each ingredient in Ipriflavone 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ipriflavone4 drug types · 391 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.

Likelihood Possible Evidence D
Immunosuppressants

Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence A
Theophylline

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence D
Ipriflavone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ipriflavone 600 mg, from the product label.

Vital Nutrients

See all Vital Nutrients products
Name
Vital Nutrients
Street Address
45 Kenneth Dooley Dr
City
Middletown
State
CT
ZipCode
06457
Web Address
vitalnutrients.net
Pharmacist Counseling Corner

Ipriflavone 600 mg by Vital Nutrients: Common Questions

Does Ipriflavone 600 mg by Vital Nutrients interact with any medications?
Yes. Based on its ingredients, Ipriflavone 600 mg has a known interaction with 391 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ipriflavone 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does ipriflavone actually help with osteoporosis?
Yes, ipriflavone is rated likely effective for osteoporosis based on clinical evidence. It's also likely effective for Paget disease. That said, results vary from person to person, and it works best as part of an overall bone health plan.
What side effects should I watch for?
Most people tolerate it well, but some experience stomach pain, diarrhea, or dizziness. A longer concern is that taking it for 6 months or more may lower your white blood cell count, so regular checkups are smart if you use it long-term.
Can I take this while pregnant or nursing?
No. There isn't enough safety data to recommend ipriflavone during pregnancy or breastfeeding. If you're pregnant or nursing and interested in bone support, talk with your doctor or pharmacist about safer options.
Why do I need to check my medications before starting?
Ipriflavone slows how your liver clears certain drugs, which can raise their levels in your blood and cause unwanted effects. This affects a wide range of medications, so it's crucial to confirm your prescriptions are safe to mix with it.
What's in the capsule besides ipriflavone?
The capsule contains cellulose, ascorbic acid, rice powder, ascorbyl palmitate, and silica — these are inactive ingredients that help hold the capsule together and preserve the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ipriflavone 600 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ipriflavone 600 mg label
Go deeper

The Full Monographs Behind Ipriflavone 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ipriflavone

Interacts with 391 drugs

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...

Read the full Ipriflavone monograph →
Sources

Sources & How We Checked

Ipriflavone 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ipriflavone 6 references
  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

See these in context on the Ipriflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team