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Dietary supplement

Irvingia 500 mg Ingredients & Drug Interactions

by Absorb Health

Irvingia 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Irvingia 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Irvingia 500 mg is a dietary supplement by Absorb Health with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Irvingia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Irvingia 500 mg by Absorb Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Irvingia 500 mg by Absorb Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Irvingia 500 mg by Absorb Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Irvingia (from Irvingia gabonensis, also called African mango seed). The capsules also contain gelatin and silica as inactive ingredients that help form and protect the supplement.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: weight management.
  • We looked for evidence on: Obesity, Hypercholesterolemia, Metabolic syndrome, Diabetes, appetite control, body weight regulation.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for Irvingia is limited. Our data shows insufficient reliable evidence to rate it for diabetes, high cholesterol, obesity, or metabolic syndrome — so we can't say whether it works for any of those purposes based on the studies we hold.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Irvingia is generally well tolerated when taken short-term. The most common side effects reported are flatulence, headache, insomnia, and nausea.

Long-term safety and product quality aren't well established, so we don't know what happens with extended use. One case of acute liver inflammation (hepatitis) linked to Irvingia supplementation has been reported, though this is rare.

The safety data advises against use during pregnancy, and there isn't enough information to recommend it while breastfeeding — talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antidiabetes drugs — Irvingia may lower your blood sugar too much. Also flag any testosterone products you're using, since combined effects are theoretically possible and not fully understood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Irvingia may be worth discussing with your doctor if you're interested in its potential effects, but the evidence for its benefits isn't established in our data. If you take antidiabetes medication or testosterone products, this supplement isn't a casual add-on — you'll need to check with your doctor or pharmacist first and monitor closely.

Long-term safety is unclear, so keep that conversation going with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Irvingia 500 mg, straight from the product label.

Brand Absorb Health
Barcode (UPC) 025706834773
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 215941
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Irvingia 500 mg by Absorb Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
025706834773
IngredientAmount% DV
Irvingia500 mg--

Other ingredients: Gelatin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature with lid tightly closed.

Formulation

Weight Management

No cutting agents

General Statements

Shop at www.absorbyourhealth.com for all your mind, body, and spirit needs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Irvingia 500 mg by Absorb Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Irvingia 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Irvingia 500 mg by Absorb Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Irvingia

Interacts with
94 drugs
500 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Irvingia monograph & interactions

Other (inactive) ingredients: Gelatin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Irvingia 500 mg by Absorb Health Drug Interactions

Want to check YOUR meds against Irvingia 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

Irvingia 94

Individual Drug Interactions

The ingredients in Irvingia 500 mg interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Irvingia 500 mg interact with drugs. Each result below shows which ingredient is responsible. Irvingia

Each ingredient & the kinds of drugs it affects

For each ingredient in Irvingia 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Irvingia2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Irvingia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Irvingia 500 mg, from the product label.

Absorb Health

See all Absorb Health products
Name
Absorb Health
Web Address
www.absorbyourhealth.com
Pharmacist Counseling Corner

Irvingia 500 mg by Absorb Health: Common Questions

Does Irvingia 500 mg by Absorb Health interact with any medications?
Yes. Based on its ingredients, Irvingia 500 mg has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Irvingia 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Irvingia if I'm pregnant or breastfeeding?
The safety data advises against Irvingia during pregnancy. For breastfeeding, there isn't enough information to know whether it's safe — talk with your doctor or pharmacist about your specific situation before taking it.
What side effects has Irvingia been linked to?
The most common ones are flatulence, headache, insomnia, and nausea. One rare case of acute liver inflammation has been reported. Most people tolerate it okay short-term, but long-term safety isn't well studied.
Does Irvingia actually work for weight loss or diabetes?
Our data shows insufficient reliable evidence to rate Irvingia for obesity, diabetes, high cholesterol, or metabolic syndrome, so we can't confirm it works for any of these purposes.
Is this safe to take long-term?
Long-term safety and product quality aren't well established. If you're thinking about taking it for weeks or months, talk with your doctor or pharmacist about what we do and don't know.
What's actually in this capsule?
Each capsule contains 500 mg of Irvingia (from African mango seed), plus gelatin and silica to make the capsule itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Irvingia 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Irvingia 500 mg label
Go deeper

The Full Monographs Behind Irvingia 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Irvingia 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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