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Dietary supplement

Ivy Plus Ingredients & Drug Interactions

by True Botanica

Ivy Plus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ivy Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ivy Plus is a dietary supplement by True Botanica with 1 active ingredient. Its ingredients are commonly taken for cough and chest congestion, bronchitis, asthma symptoms.Based on those ingredients, 280 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ivy Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ivy Plus by True Botanica

Ask about any prescription or over-the-counter medication and we check it for interactions with Ivy Plus by True Botanica — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ivy Plus by True Botanica

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ivy Plus is a single-ingredient supplement containing ivy leaf extract — the concentrated compound from English ivy leaves. This form is a standardized extract designed to be safer than the raw plant, which can cause poisoning or skin reactions if ingested.

The capsule also holds several inactive ingredients — fructose fiber (Frutafit), cellulose, maltodextrin, and ivy — that serve as fillers and binders to hold the product together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see English Ivy's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: respiratory tract health and cough relief.
  • We looked for evidence on: Bronchitis, Cough, Respiratory tract infections, chest congestion, asthma symptoms, sore throat.
  • The closest evidence on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Cough.

The evidence for ivy leaf extract's effectiveness isn't established in the data we hold. The facts show insufficient reliable evidence for uses including bronchitis, respiratory tract infections, gout, spasticity, and neuropathic pain — meaning there either aren't enough quality studies, or the studies available don't support a clear benefit.

If you're considering this supplement for a specific health concern, talk with your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient English Ivy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The standardized leaf extract in Ivy Plus is generally well tolerated, which is an important distinction: the raw plant is toxic and risky. When taken by mouth, the most common side effects reported are abdominal pain, diarrhea, nausea, vomiting, and skin irritation — a small number of people experience these, but most tolerate it without problems.

Pregnancy and breastfeeding are different stories. There isn't enough reliable safety information to use this during pregnancy, so the data advises against it.

Safety while breastfeeding is also unknown, so avoid it unless your doctor specifically directs you to use it.

Side effects, ingredient by ingredient English Ivy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — English Ivy.
  • The most serious interaction on file is rated Moderate.
  • For scale: 280 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Ivy Plus, check any medications that are broken down by the liver enzymes CYP2C19, CYP2D6, or CYP2C8 — this includes many antidepressants, blood pressure drugs, diabetes medications, and pain relievers. The interaction is theoretical but rated Moderate for each enzyme system.

Use the medication checker below to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Ivy Plus is a single-ingredient supplement with lab-based evidence of a theoretical interaction with hundreds of medications — mainly through liver enzyme inhibition. If you take any prescription drugs or regular over-the-counter medications, run them through the interaction checker on this page before you start.

It's not established as effective for the conditions people typically use it for. Steer clear during pregnancy and breastfeeding unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ivy Plus, straight from the product label.

Brand True Botanica
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336227
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ivy Plus by True Botanica, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Ivy Leaf Extract100 mg--

Other ingredients: Frutafit, Cellulose, Maltodextrin, Ivy

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ivy keeps the entire respiratory tract, from sinuses to lungs, healthy. It loosens up mucous; soothes a temporary cough; helps to take deeper easier breaths.

Formulation

Contains no milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, sesame, soy or wheat. Gluten free.

Vegetarian capsules.

A full spectrum formula

Precautions

Consult your health care provider before using this product if you are pregnant, lactating or have other medical concerns or compatibility issues.

Do not use this product if allergies to the listed ingredients are known to exist or if any adverse effects result after taking the first dose.

Keep out of the reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Usage: One capsule twice daily or as suggested by your health care provider.

Brand IP Statement(s)

FrutaFit -Inulin, a registered trademark of Imperial-Sensus, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ivy Plus by True Botanica label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ivy Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ivy Plus by True Botanica

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Ivy Leaf Extract

Interacts with
280 drugs
100 mg per serving

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

Ivy Leaf Extract monograph & interactions

Other (inactive) ingredients: Frutafit, Cellulose, Maltodextrin, Ivy. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ivy Plus by True Botanica Drug Interactions

Want to check YOUR meds against Ivy Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
280Drugs
280 Moderate

Ingredients driving the most interactions

Ivy Leaf Extract 280

Individual Drug Interactions

The ingredients in Ivy Plus interact with 280 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ivy Plus interact with drugs. Each result below shows which ingredient is responsible. Ivy Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ivy Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ivy Leaf Extract3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Ivy Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ivy Plus, from the product label.

True Botanica

See all True Botanica products
Name
True Botanica, LLC
Street Address
1005 Richards Road, Suite D
City
Hartland
State
WI
ZipCode
53029
Phone Number
1-800-315-8783
Web Address
www.truebotanica.com
Pharmacist Counseling Corner

Ivy Plus by True Botanica: Common Questions

Does Ivy Plus by True Botanica interact with any medications?
Yes. Based on its ingredients, Ivy Plus has a known interaction with 280 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ivy Plus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is in Ivy Plus?
It's one active ingredient: ivy leaf extract from English ivy. The capsule also contains inactive fillers — fructose fiber, cellulose, maltodextrin, and ivy — to hold it together and protect the extract.
Does ivy leaf extract actually work for anything?
The evidence isn't clear enough to say. Our data shows insufficient reliable evidence for bronchitis, respiratory infections, gout, spasticity, and neuropathic pain. If you're thinking about it for a specific reason, ask your pharmacist what the science shows.
Is the extract safe to swallow, or is it the raw plant that's dangerous?
The standardized extract in this capsule is the safer form — the raw plant is toxic and can cause poisoning. The extract is generally well tolerated, though some people report abdominal pain, diarrhea, nausea, or vomiting.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety data during pregnancy, so it's best avoided. Safety while breastfeeding is also unknown, so don't use it unless your doctor tells you it's okay.
Why does this interact with so many medications?
Ivy extract appears to slow down three major liver enzyme systems your body uses to break down drugs — CYP2C19, CYP2D6, and CYP2C8. Hundreds of medications rely on one or more of these pathways, so the potential affected list is large.
Has this interaction actually hurt anyone?
Not that we know of — the interaction is shown in lab studies but hasn't been reported in real people yet. That doesn't mean it won't happen, which is why checking your specific medications beforehand is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ivy Plus label
Go deeper

The Full Monographs Behind Ivy Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

English Ivy

Interacts with 280 drugs

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...

Read the full English Ivy monograph →
Sources

Sources & How We Checked

Ivy Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

English Ivy 13 references
  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2

See these in context on the English Ivy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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