Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

JointRite Ingredients & Drug Interactions

by Nutralife

JointRite label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking JointRite against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

JointRite is a dietary supplement by Nutralife with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 921 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin D3, S-Adenosyl Methionine, Glucosamine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against JointRite by Nutralife

Ask about any prescription or over-the-counter medication and we check it for interactions with JointRite by Nutralife — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of JointRite by Nutralife

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

JointRite contains four active ingredients. Vitamin D3 supports bone health and calcium regulation.

Hyaluronic acid is a naturally occurring compound used for joint lubrication and skin hydration. Glucosamine HCl is an amino sugar that supports cartilage structure.

SAMe (S-adenosyl methionine) is a compound that plays a role in cell function and mood regulation. The product also contains several inactive ingredients—cellulose, mannitol, citric acid, stearic acid, silica, maltodextrin, sodium starch glycolate, modified cellulose gum, and coating ingredients—which serve as fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: joint comfort and bone health.
  • We looked for evidence on: Fibromyalgia, Osteoarthritis, Joint pain, Cartilage health.
  • The strongest evidence on file: Same is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Glucosamine is rated "Likely Effective" for Osteoarthritis.
  • Also on file: Same is rated "Insufficient Reliable Evidence To Rate" for Fibromyalgia.

Vitamin D3 is effective for treating rickets, osteomalacia (soft bones), renal bone disease, and hypoparathyroidism. Glucosamine HCl is likely effective for osteoarthritis.

SAMe is likely effective for osteoarthritis and possibly effective for depression and cholestasis (bile duct blockage). Hyaluronic acid is possibly effective for dry eye and venous leg ulcers; however, evidence for its use in aging skin is insufficient.

The data we hold does not establish effectiveness for hyaluronic acid in allergic rhinitis or sexual dysfunction.

The evidence, ingredient by ingredient Vitamin D Hyaluronic Acid Glucosamine Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, though very high doses over time can cause toxicity with symptoms including high blood calcium, bone loss in adults, and reduced growth in children. At recommended doses, it is often used in pregnancy, but only under your doctor's guidance; safety at higher doses is not established.

Hyaluronic acid appears generally well tolerated when taken by mouth, though long-term safety of supplements is not fully studied—the data advises caution with oral supplements unless your doctor recommends it. Topically, it may cause eczema, redness, itching, or wound infection in rare cases.

Glucosamine HCl is generally well tolerated orally, with the most common side effects being bloating, constipation, cramps, diarrhea, heartburn, and nausea; rare cases of allergic reactions and asthma exacerbation have been reported. Safety data during pregnancy and breastfeeding are insufficient, so the data advises against use unless your doctor advises otherwise.

SAMe is generally well tolerated at typical doses, though higher doses increase side effects; common effects include stomach upset, headache, dizziness, insomnia, and nervousness. It can trigger mania in people with bipolar disorder.

Safety during breastfeeding is not well established; pregnancy safety is possibly safe.

Side effects, ingredient by ingredient Vitamin D Hyaluronic Acid Glucosamine Same

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Same, Glucosamine, Vitamin D.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 922 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking JointRite, double-check with your doctor or pharmacist if you take warfarin or any blood thinner (Major interaction with glucosamine). Also flag any heart rhythm medications (verapamil, diltiazem, digoxin), thiazide diuretics, statin cholesterol drugs, serotonergic antidepressants, levodopa for Parkinson disease, diabetes medications, cancer chemotherapy, or acetaminophen.

No interactions are documented for the ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

JointRite may help with osteoarthritis and joint support, particularly through its glucosamine and SAMe content. If you take warfarin or a heart rhythm medication, antidepressants, levodopa, or a statin, speak with your doctor or pharmacist before starting—this product has several documented interactions that could affect how those medications work.

At recommended doses, the ingredients are generally well tolerated, though vitamin D toxicity is a concern with very high long-term intake.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about JointRite, straight from the product label.

Brand Nutralife
Barcode (UPC) 686149310219
Net contents 60 Enteric Coated Caplet(s)
Market status On market
Date entered into DSLD Feb 23, 2016
DSLD ID 56972
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for JointRite by Nutralife, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Caplet(s)
Maximum serving Sizes:
2 Caplet(s)
Servings per container
30
UPC/BARCODE
686149310219
IngredientAmount% DV
Vitamin D32000 IU500%
Hyaluronic Acid50 mg--
Glucosamine HCl1000 mg--
S-Adenosyl Methionine266 mg--

Other ingredients: Glucosamine Hydrochloride, S-Adenosyl-Methionine Tosylate Disulfate, Cellulose, Mannitol, Citric Acid, Stearic Acid, Silica, Maltodextrin, Sodium Starch Glycolate, modified Cellulose Gum, Coating Ingredients

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Joint Rite's unique and powerful formulation combines SAMe with other cutting edge ingredients to help rejuvenate joints and cartilage while enhancing joint lubrication for the ultimate in joint comfort and overall bone health.*

266 mg SAMe 1000 mg Glucosamine 50 mg Hyaluronic Acid 2000 IU Vitamin D3 with SAMe

General Statements

SAMe is the time proven supplement for joint health. Clinical studies, involving thousands of participants, indicate the many benefits SAMe has to offer, which can include: production of proteoglycans essential to joint lubrication, maintaining youthful spring of joints, and promoting overall joint comfort.* Glucosamine may help produce glycoaminoglycans, molecules essential for cartilage and connective tissue support, and is considered critical for optimal joint mobility and flexibility.* Hyaluronic Acid is an essential building block in joint fluid, which lubricates the joints and acts as a shock absorber by cushioning the joint.* Vitamin D3 promotes the absorption of calcium essential to bone health.*

Nutralife Joint Rite caplets are sealed in blister packs to ensure product safety, quality, and freshness.

Advanced scientific formula for an active mobile lifestyle

Blister Packed

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

This product should be stored in a cool, dry place.

Formulation

This product contains no peanuts, eggs, dairy, soy, wheat, gluten, tree nuts, crustacean shellfish or fish.

Precautions

Do not use if blister foil is punctured or appears in any way to have been tampered with.

Keep out of reach of children.

Caution: If you suffer from bipolar disorder or manic depression, do not use this product.

If you are currently taking prescription anti-depressants, consult your physician before using this product. If you are pregnant or lactating, consult your physician before using this product.

Seals/Symbols

made in USA with imported ingredients

nutraLife Health Products Incorporated

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two caplets per day on an empty stomach, or as directed by a physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

JointRite by Nutralife label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

JointRite label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in JointRite by Nutralife

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
2000 IU per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Hyaluronic Acid

No known
interactions
50 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Glucosamine HCl

Interacts with
170 drugs
1000 mg per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine HCl monograph & interactions

S-Adenosyl Methionine

Interacts with
189 drugs
266 mg per serving

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

S-Adenosyl Methionine monograph & interactions

Other (inactive) ingredients: Glucosamine Hydrochloride, S-Adenosyl-Methionine Tosylate Disulfate, Cellulose, Mannitol, Citric Acid, Stearic Acid, Silica, Maltodextrin, Sodium Starch Glycolate, Modified Cellulose Gum, Coating Ingredients. These complete the product’s ingredient list but are not active constituents.

Interaction report

JointRite by Nutralife Drug Interactions

Want to check YOUR meds against JointRite?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
921Drugs
2 Major 282 Moderate 637 Minor

Ingredients driving the most interactions

Vitamin D3 715
S-Adenosyl Methionine 189
Glucosamine HCl 170

Individual Drug Interactions

The ingredients in JointRite interact with 921 drugs. Click any drug to see the details.

3 of the 4 ingredients in JointRite interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 S-Adenosyl Methionine Glucosamine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in JointRite with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

S-Adenosyl Methionine2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
S-Adenosyl Methionine full monograph & interactions

Glucosamine HCl4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for JointRite, from the product label.

Nutralife

See all Nutralife products
Name
Nutralife Health Products, Inc.
City
Lakewood
State
NJ
ZipCode
08701
Phone Number
877-688-7254
Pharmacist Counseling Corner

JointRite by Nutralife: Common Questions

Does JointRite by Nutralife interact with any medications?
Yes. Based on its ingredients, JointRite has a known interaction with 921 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
JointRite contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is JointRite safe to take if I'm pregnant?
Vitamin D3 at recommended doses is often used in pregnancy under medical guidance. Glucosamine and SAMe safety data are insufficient in pregnancy—the data advises caution or avoidance unless your doctor recommends it. Talk with your doctor before starting, as each ingredient has different pregnancy information and your personal situation matters.
Can I take JointRite while breastfeeding?
Vitamin D3 is likely safe while breastfeeding at recommended doses. Glucosamine and SAMe have insufficient safety data while breastfeeding, so the guidance is to avoid them unless your doctor advises otherwise. Discuss this with your doctor or pharmacist before you start.
What are the most common side effects?
Glucosamine may cause bloating, constipation, cramps, diarrhea, heartburn, or nausea. SAMe can cause stomach upset, headache, dizziness, insomnia, and nervousness, especially at higher doses. Vitamin D and hyaluronic acid are generally well tolerated when used as directed.
Does JointRite really work for joint pain?
Glucosamine HCl and SAMe are both likely effective for osteoarthritis. Vitamin D3 supports bone health and calcium metabolism but is not specifically rated for joint pain. Results vary between individuals, and it may take time to notice a benefit.
Can I take JointRite with acetaminophen?
There is a documented Minor interaction: acetaminophen may interfere with glucosamine's activity. If you take both, monitor your pain control, and talk with your pharmacist about timing or alternatives if pain relief decreases.
What is hyaluronic acid in this product for?
Hyaluronic acid is a naturally occurring compound that supports joint lubrication and skin hydration. It is possibly effective for dry eye and venous leg ulcers, though evidence for other uses is limited or not established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

JointRite label
Go deeper

The Full Monographs Behind JointRite’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Same

Interacts with 189 drugs

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the qu...

Read the full Same monograph →
Sources

Sources & How We Checked

JointRite's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 119 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
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Hyaluronic Acid 4 references
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