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Dietary supplement

Krill Oil 1000 Ingredients & Drug Interactions

by GNC Triple Strength

Krill Oil 1000 label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Krill Oil 1000 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Krill Oil 1000 is a dietary supplement by GNC Triple Strength with 1 active ingredient. Its ingredients are commonly taken for heart and cholesterol support, high triglycerides, joint pain and inflammation.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Neptune Krill Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Krill Oil 1000 by GNC Triple Strength

Ask about any prescription or over-the-counter medication and we check it for interactions with Krill Oil 1000 by GNC Triple Strength — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Krill Oil 1000 by GNC Triple Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: Neptune Krill Oil. Krill are tiny Antarctic shrimp-like creatures, and their oil is rich in omega-3 fatty acids (the same type found in fish oil) as well as a compound called astaxanthin, a natural antioxidant.

The softgel itself is made from gelatin, sorbitol, glycerin, and an enteric coating—these are inactive ingredients that help the capsule dissolve and protect the contents in your stomach.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Krill Oil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: reduce inflammation and support joint and heart health.
  • We looked for evidence on: Cardiovascular disease (CVD), Hyperlipidemia, Hypertriglyceridemia, Osteoarthritis, Rheumatoid arthritis (RA), inflammation — and 1 related terms.
  • The closest evidence on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD) (Natural Medicines).
  • Also on file: Krill Oil is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertriglyceridemia, Osteoarthritis, Rheumatoid arthritis (RA).

Krill oil is possibly effective for dry eye. For aging skin, Alzheimer disease, cancer, high cholesterol (hyperlipidemia), and cognitive function, the evidence available to us isn't established or is considered insufficient to rate it.

If you're considering krill oil for any of those other uses, talk with your doctor about what the current science shows and whether it makes sense for you.

The evidence, ingredient by ingredient Krill Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Krill oil is generally well tolerated at doses up to 4 grams daily. The most common side effects are digestive—bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, and stomach discomfort.

Headache, tiredness, and dizziness have been reported rarely. Overall, these effects seem to be milder and happen less often with krill oil than with fish oil.

Avoid krill oil if you have a shellfish allergy, since krill is a shellfish product. Use caution if you have a bleeding disorder.

The safety data during pregnancy and breastfeeding isn't robust enough to know either way—talk with your doctor or pharmacist before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Krill Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Krill Oil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on any blood thinner (like warfarin) or antiplatelet drug (like aspirin or clopidogrel)—krill oil may theoretically increase bleeding risk. Also double-check if you take diabetes medication, since krill oil might lower blood sugar.

These are the main medication types to watch for with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Krill oil may help with dry eye, though evidence for other common uses isn't established yet. It's worth considering if dry eye is your main concern and you don't take blood thinners or diabetes medication.

If you do take those drugs, or if you have a shellfish allergy or bleeding disorder, check with your doctor or pharmacist before starting. Most people tolerate it well, with mild digestive side effects being the main complaint.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Krill Oil 1000, straight from the product label.

Brand GNC Triple Strength
Barcode (UPC) 048107117535
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Aug 24, 2016
DSLD ID 64197
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Krill Oil 1000 by GNC Triple Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
048107117535
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Total Fat1 Gram(s)2%
Neptune Krill Oil1000 mg--

Other ingredients: Gelatin, Sorbitol, Glycerin, Enteric Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

~ Clinically shown to reduce CRP by 30% a key marker of joint & heart health ~ Clincally shown to improve joint comfort & supports the body's natural anti-inflammatory response ~ Promotes heart health & supports healthy cholesterol levels

In a randomized, double-blind, placebo-controlled clinical study, 87 volunteers were supplemented with either 300 mg of Neptune Krill or placebo. After 30 days subjects receiving Neptune Krill Oil demonstrated significant improvements in C-Reactive Protein levels, joint comfort and joint function.

New

General

Code 883821 ING

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one softgel capsule daily. For maximum benefits, take as directed every day.

Formula

Contains: Crustaceans (Krill).

Not less than 20% total Omega-3 Fatty Acids.

~ Extra strength 1000 mg of Neptune Krill Oil providing highly absorbable forms of Omega-3 fatty acids

Precautions

Contains: Crustaceans (Krill).

Brand IP Statement(s)

100% Pure Neptune Technologies & Bioressources, Inc., Qc, Canada. NKO is a trademark of Neptune Technologies & Bioressources, Inc., Qc, Canada.

NKO

Storage

Keep out of reach of children.

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Krill Oil 1000 by GNC Triple Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Krill Oil 1000 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Krill Oil 1000 by GNC Triple Strength

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Neptune Krill Oil

Interacts with
208 drugs
1000 mg per serving

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglyce...

Neptune Krill Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Sorbitol, Glycerin, Enteric Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

Krill Oil 1000 by GNC Triple Strength Drug Interactions

Want to check YOUR meds against Krill Oil 1000?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Neptune Krill Oil 208

Individual Drug Interactions

The ingredients in Krill Oil 1000 interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Krill Oil 1000 interact with drugs. Each result below shows which ingredient is responsible. Neptune Krill Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Krill Oil 1000 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Neptune Krill Oil2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, krill oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Taking high doses of omega-3 fatty acids from fish oil can modestly decrease platelet aggregation. Since krill oil also contains these fatty acids, taking high doses of krill oil might also inhibit platelet aggregation. Theoretically, taking high doses of krill oil with antiplatelet or anticoagulant drugs might increase the risk of bleeding. However, the omega-3 content of krill oil is much lower than that of fish oil.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking krill oil with antidiabetes drugs might increase the risk of hypoglycemia.
Some research in animals and humans shows that krill oil might lower blood glucose levels. However, a small study shows that taking krill oil does not reduce blood glucose levels in patients with type 2 diabetes, most of whom were taking antidiabetes drugs.

Likelihood Possible Evidence B
Neptune Krill Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Krill Oil 1000, from the product label.

GNC Triple Strength

See all GNC Triple Strength products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Krill Oil 1000 by GNC Triple Strength: Common Questions

Does Krill Oil 1000 by GNC Triple Strength interact with any medications?
Yes. Based on its ingredients, Krill Oil 1000 has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Krill Oil 1000 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will krill oil actually help my dry eyes?
Krill oil is rated possibly effective for dry eye, meaning some evidence supports it but it's not proven in everyone. Whether it'll help you is individual—talk it over with your eye doctor or pharmacist to see if it makes sense for your situation.
What are the side effects I might notice?
Most people experience digestive issues: bloating, decreased appetite, diarrhea, fishy burps, flatulence, heartburn, nausea, or stomach discomfort. Headache, tiredness, and dizziness happen rarely. These effects tend to be milder with krill oil than with fish oil.
Can I take this if I'm allergic to shellfish?
No—krill are shellfish, so you should avoid this product entirely if you have a shellfish allergy. Talk to your doctor or pharmacist about alternatives if that's a concern for you.
Is it safe to use while I'm pregnant?
There isn't enough reliable safety data to know either way. Talk with your doctor or pharmacist before using it during pregnancy so you can make the best choice for you and your baby.
How much of this product is actually the active ingredient?
The softgel contains Neptune Krill Oil as the single active ingredient. The other ingredients—gelatin, sorbitol, glycerin, and the enteric coating—are there to hold it together and help it work in your body, not to add therapeutic benefit.
Can I take this with fish oil?
The product facts we have don't cover that combination. Since both contain similar omega-3 fatty acids, talk with your doctor or pharmacist before taking them together—they can advise based on your specific health situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Krill Oil 1000 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Krill Oil 1000 label
Go deeper

The Full Monographs Behind Krill Oil 1000’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Krill Oil

Interacts with 208 drugs

Krill oil is a source of omega-3 fatty acids (EPA and DHA) bound to phospholipids, which may help absorption. It is most studied for lowering triglycerides and supporting heart health, but t...

Read the full Krill Oil monograph →
Sources

Sources & How We Checked

Krill Oil 1000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Krill Oil 13 references
  1. Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
  2. Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
  3. Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
  4. Bunea R, El Farrah K, Deutsch L. Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 2004;9:420-8.
  5. Sampalis F, Bunea R, Pelland MF, et al. Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 2003;8:171-9.
  6. Harris WS, Miller M, Tighe AP, et al. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008;197:12-24. PubMed
  7. Tandy S, Chung RW, Wat E, et al. Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem 10-14-2009;57:9339-45. PubMed
  8. Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., and Rains, T. M. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr.R PubMed
  9. Albert BB, Derraik JG, Brennan CM, et al. Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men. Am J Clin Nutr 2015;102(1):49-57.
  10. Berge K, Musa-Veloso K, Harwood M, Hoem N, Burri L. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res 2014;34(2):126-33. PubMed
  11. Lobraico JM, DiLello LC, Butler AD, Cordisco ME, Petrini JR, Ahmadi R. Effects of krill oil on endothelial function and other cardiovascular risk factors in participants with type 2 diabetes, a randomized controlled trial. BMJ Open Diabetes Res Care. 2015 PubMed
  12. van der Wurff ISM, von Schacky C, Bergeland T, Zeegers MP, Kirschner PA, de Groot RHM. Krill oil supplementation's effect on school grades in typically developing adolescents. Prostaglandins Leukot Essent Fatty Acids 2023;191:102553. PubMed
  13. van der Wurff ISM, von Schacky C, Bergeland T, et al. Effect of 1 year krill oil supplementation on cognitive achievement of Dutch adolescents: A double-blind randomized controlled trial. Nutrients. 2019;11(6):1230. PubMed

See these in context on the Krill Oil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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