L-Arginine L-Ornithine 750 mg Ingredients & Drug Interactions
by BIOVEA
What is this page for?
First and foremost: checking L-Arginine L-Ornithine 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Arginine L-Ornithine 750 mg is a dietary supplement by BIOVEA with 2 active ingredients. Its ingredients are commonly taken for athletic performance and recovery, reducing fatigue, sleep and stress support.Based on those ingredients, 403 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Arginine L-Ornithine 750 mg by BIOVEA
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Arginine L-Ornithine 750 mg by BIOVEA
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: L-Arginine Hydrochloride and L-Ornithine Hydrochloride. L-Arginine is an amino acid that plays a role in blood vessel function and blood pressure regulation.
L-Ornithine is another amino acid thought to support athletic performance and skin health, though the evidence is limited. The capsule also contains inactive ingredients—hydroxypropyl methylcellulose, rice flour, and vegetable magnesium stearate—which help form and stabilize the capsule.
Does it work?
Moderate evidence
The evidence supporting these ingredients is mixed. L-Ornithine is rated possibly effective for athletic performance; for dry skin, insomnia, and gum disease (periodontitis), the evidence is insufficient to say whether it works.
L-Arginine effectiveness ratings aren't established in our data. If you're taking this for a specific reason, talk it over with your doctor or pharmacist to see whether the evidence supports its use for your goal.
How safe is it?
Well-documented data
L-Arginine is generally well tolerated short-term, though it can lower blood pressure and isn't safe for everyone without medical guidance. Common side effects from oral L-Arginine include abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing.
L-Ornithine is generally well tolerated short-term, but long-term safety hasn't been well studied. For pregnancy, L-Arginine is rated possibly safe, but L-Ornithine lacks adequate safety data—avoid it during pregnancy and breastfeeding unless your doctor advises otherwise.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take blood pressure medications (ACE inhibitors, ARBs, other antihypertensives, or isoproterenol), blood thinners (anticoagulants or antiplatelet drugs), potassium-sparing diuretics, diabetes medications, or sildenafil (Viagra). All carry moderate interaction risks with L-Arginine in this formula.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is aimed at people interested in athletic performance and muscle support, but it comes with real medication interactions you need to know about, especially if you take blood pressure medications, blood thinners, diabetes drugs, or potassium-sparing diuretics. The evidence for its benefits is limited.
Before you start, check your exact medications with your doctor or pharmacist—these interactions affect over 400 individual drugs, so this conversation matters.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Arginine L-Ornithine 750 mg, straight from the product label.
| Brand | BIOVEA |
|---|---|
| Barcode (UPC) | 818423022758 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 24, 2019 |
| DSLD ID | 207497 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Arginine L-Ornithine 750 mg by BIOVEA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Ornithine Hydrochloride | 250 mg | -- |
| L-Arginine Hydrochloride | 500 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Rice Flour, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
GMP Compliant Gluten free Non-GMO
Formulation
Gluten free Non-GMO
General Statements
Premium quality guaranteed since 2001. BIOVEA is committed to product quality to support you and your family's wellness goals. Because we feel so strongly about the quality, potency and purity of our products, we 100% guarantee your satisfaction with every purchase.
Guaranteed premium quality
Amino acid
Suggested/Recommended/Usage/Directions
Suggested Daily Intake: Take 1 capsule up to three times daily, or as directed by a healthcare professional. For best results, take on an empty stomach.
Precautions
Warning: If you are pregnant or lactating, consult a healthcare professional before using this product.
Keep out of reach of children.
Do not use this product if the safety seal on the bottle is broken.
Storage
Store in a cool, dry place.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Arginine L-Ornithine 750 mg by BIOVEA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Arginine L-Ornithine 750 mg by BIOVEA
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Ornithine Hydrochloride
No knowninteractions
Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...
L-Ornithine Hydrochloride monograph & interactionsL-Arginine Hydrochloride
Interacts with403 drugs
L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...
L-Arginine Hydrochloride monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice Flour, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
L-Arginine L-Ornithine 750 mg by BIOVEA Drug Interactions
HelloPharmacist Interaction Report
BIOVEA L-Arginine L-Ornithine 750 mg does interact with several medication types, through its L-arginine content.
The most serious concerns are moderate-severity risks with blood pressure medications (antihypertensive drugs, ACE inhibitors, ARBs, and the heart drug isoproterenol) and with blood thinners (anticoagulant and antiplatelet drugs). L-arginine can lower blood pressure and may increase bleeding risk when combined with these medications.
Read the full breakdown — every affected drug type, severity by severity
Additionally, this product carries moderate interactions with potassium-sparing diuretics (water pills that preserve potassium), which could raise potassium levels too high, and with diabetes medications, which could lower blood sugar further. Sildenafil (Viagra) also poses a moderate risk for added blood pressure-lowering effects when combined with L-arginine.
L-Ornithine Hydrochloride was checked and has no interactions documented in our data. Because these interactions span 403 individual medications, it's especially important to run your exact prescriptions through the medication checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Arginine L-Ornithine 750 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Arginine L-Ornithine 750 mg interact with 403 drugs. Click any drug to see the details.
1 of the 2 ingredients in L-Arginine L-Ornithine 750 mg interact with drugs. Each result below shows which ingredient is responsible. L-Arginine Hydrochloride
AbciximabReoPro
How Abciximab interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Read the full L-arginine Hydrochloride + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Potassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Potassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine Hydrochloride + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with L-Arginine L-Ornithine 750 mg — through 1 ingredient. Tap an ingredient for the detail:
L-arginine HydrochlorideAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full L-arginine Hydrochloride + Anacaulase-bcdb interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Arginine L-Ornithine 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Arginine Hydrochloride
Ace Inhibitors (Aceis)
Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.
Angiotensin Receptor Blockers (Arbs)
Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.
Antihypertensive Drugs
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.
Isoproterenol (Isuprel)
Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.
Potassium-Sparing Diuretics
Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Testosterone
Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for L-Arginine L-Ornithine 750 mg, from the product label.
BIOVEA
See all BIOVEA products- Name
- BIOVEA
- Street Address
- 9160 E. Bahia Dr.
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85260
- Web Address
- www.biovea.com
L-Arginine L-Ornithine 750 mg by BIOVEA: Common Questions
Does L-Arginine L-Ornithine 750 mg by BIOVEA interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the main side effects I should watch for?
Is this proven to help with athletic performance?
How long can I safely take this?
Why does this interact with so many medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Arginine L-Ornithine 750 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Arginine L-Ornithine 750 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Ornithine
Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...
Read the full Ornithine monograph → Herb & supplement monographL-arginine
Interacts with 403 drugsL-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...
Read the full L-arginine monograph →Sources & How We Checked
L-Arginine L-Ornithine 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 67 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ornithine 1 reference
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
L-arginine 66 references
- Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
- Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
- Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
- Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
- Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
- Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
- Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
- Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
- Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
- Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
- Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
- Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
- Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
- de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
- Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
- Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
- Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
- Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
- Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
- Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
- Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
- Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
- Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16(1):23-26. PubMed
- Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35(1):32-37.
- Mansoor, J. K., Morrissey, B. M., Walby, W. F., Yoneda, K. Y., Juarez, M., Kajekar, R., Severinghaus, J. W., Eldridge, M. W., and Schelegle, E. S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt.M
- Neri, I., Jasonni, V. M., Gori, G. F., Blasi, I., and Facchinetti, F. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Matern.Fetal Neonatal Med. 2006;19(5):277-281.
- Lucotti, P., Setola, E., Monti, L. D., Galluccio, E., Costa, S., Sandoli, E. P., Fermo, I., Rabaiotti, G., Gatti, R., and Piatti, P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in
- Savoye, G., Jemaa, Y., Mosni, G., Savoye-Collet, C., Morcamp, P., Dechelotte, P., Bouin, M., Denis, P., and Ducrotte, P. Effects of intragastric L-arginine administration on proximal stomach tone under basal conditions and after an intragastric diet. Dig PubMed
- Facchinetti, F., Saade, G. R., Neri, I., Pizzi, C., Longo, M., and Volpe, A. L-arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens.Pregnancy. 2007;26(1):121-130. PubMed
- Jovanovic, A., Gerrard, J., and Taylor, R. The second-meal phenomenon in type 2 diabetes. Diabetes Care 2009;32(7):1199-1201. PubMed
- Fontanive P, Saponati G, Iurato A, et al. Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. Med.Sci.Monit. 2009;15:CR606-11.
- Doutreleau, S., Rouyer, O., Di, Marco P., Lonsdorfer, E., Richard, R., Piquard, F., and Geny, B. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin.Nutr. 2010;91(5):1261-1267. PubMed
- Ast, J., Jablecka, A., Bogdanski, P., Smolarek, I., Krauss, H., and Chmara, E. Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med.Sci.Monit. 2
- Saleh, A. I., Abdel Maksoud, S. M., El-Maraghy, S. A., and Gad, M. Z. Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. J Cardiovasc.Pharmacol.Ther 2011;16(1):53-62. PubMed
- Dong, J. Y., Qin, L. Q., Zhang, Z., Zhao, Y., Wang, J., Arigoni, F., and Zhang, W. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am.Heart J 2011;162(6):959-965. PubMed
- Hertz, P. and Richardson, J. A. Arginine-induced hyperkalemia in renal failure patients. Arch.Intern.Med. 1972;130(5):778-780. DOI
- Bushinsky, D. A. and Gennari, F. J. Life-threatening hyperkalemia induced by arginine. Ann.Intern.Med. 1978;89(5 Pt 1):632-634. PubMed
- Adams, M. R., Forsyth, C. J., Jessup, W., Robinson, J., and Celermajer, D. S. Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men. J Am Coll.Cardiol 1995;26(4):1054-1061. PubMed
- Dell'Omo, G., Catapano, G., Ebel, M., Gazzano, A., Ducci, M., Del, Chicca M., Clerico, A., and Pedrinelli, R. [Pressor, renal and endocrine effects of systemic infusion of L-arginine in hypertensive patients]. Ann.Ital Med.Int. 1995;10(2):107-112.
- Higashi, Y., Oshima, T., Ozono, R., Watanabe, M., Matsuura, H., and Kajiyama, G. Effects of L-arginine infusion on renal hemodynamics in patients with mild essential hypertension. Hypertension 1995;25(4 Pt 2):898-902.
- Bode-Boger, S. M., Boger, R. H., Creutzig, A., Tsikas, D., Gutzki, F. M., Alexander, K., and Frolich, J. C. L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin.Sci.(Lond) 1994;87(3):303
- Marfella, R., Acampora, R., Verrazzo, G., Ziccardi, P., De, Rosa N., Giunta, R., and Giugliano, D. Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients. Diabetes Care 1996;19(9):934-939. PubMed
- Giugliano, D., Marfella, R., Verrazzo, G., Acampora, R., Coppola, L., Cozzolino, D., and D'Onofrio, F. The vascular effects of L-Arginine in humans. The role of endogenous insulin. J Clin.Invest 2-1-1997;99(3):433-438. PubMed
- Khan, F., Litchfield, S. J., McLaren, M., Veale, D. J., Littleford, R. C., and Belch, J. J. Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon. Arthritis Rheum. 1997;40(2):352-357.
- Wolf, A., Zalpour, C., Theilmeier, G., Wang, B. Y., Ma, A., Anderson, B., Tsao, P. S., and Cooke, J. P. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll.Cardiol 3-1-1997;29(3):479-485. PubMed
- Schellong, S. M., Boger, R. H., Burchert, W., Bode-Boger, S. M., Galland, A., Frolich, J. C., Hundeshagen, H., and Alexander, K. Dose-related effect of intravenous L-arginine on muscular blood flow of the calf in patients with peripheral vascular disease
- Marietta, M., Facchinetti, F., Neri, I., Piccinini, F., Volpe, A., and Torelli, G. L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release. Thromb.Res 10-15-1997;88(2):229-235. PubMed
- Bauer JD, Isenring E, Waterhouse M. The effectiveness of a specialised oral nutrition supplement on outcomes in patients with chronic wounds: a pragmatic randomised study. J Hum Nutr Diet. 2013 Oct;26(5):452-8. PubMed
- Vadillo-Ortega F, Perichart-Perera O, Espino S, et al. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011 May 19;342:d2901. PubMed
- Camarena Pulido EE, García Benavides L, Panduro Barón JG, et al. Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial. Hypertens Pregnancy. 2016;35(2):217-25. PubMed
- Yokota T, Hamauchi S, Yoshida Y, et al. A phase II study of HMB/Arg/Gln against oral mucositis induced by chemoradiotherapy for patients with head and neck cancer. Support Care Cancer. 2018;26(9):3241-3248. PubMed
- Binet Q, Dufour I, Agneessens E, et al. The second case of a young man with L-arginine-induced acute pancreatitis. Clin J Gastroenterol. 2018;11(5):424-427. PubMed
- El Taieb M, Hegazy E, Ibrahim A. Daily oral l-arginine plus tadalafil in diabetic patients with erectile dysfunction: A double-blinded, randomized, controlled clinical trial. J Sex Med. 2019;16(9):1390-1397.
- Gallo L, Pecoraro S, Sarnacchiaro P, Silvani M, Antonini G. The daily therapy with L-arginine 2,500 mg and tadalafil 5 mg in combination and in monotherapy for the treatment of erectile dysfunction: A prospective, randomized multicentre study. Sex Med. 20 PubMed
- de la Parra PR, González-Cruz MÁ, Ferreiro-Marin A, Casaubón-Garcín PR. L-arginine-induced esophagitis, report of six cases. Bol Med Hosp Infant Mex. 2020;77(1):38-41. PubMed
- El-Wakeel LM, Fouad FA, Saleem MD, Saber-Khalaf M. Efficacy and tolerability of sildenafil/l-arginine combination relative to sildenafil alone in patients with organic erectile dysfunction. Andrology. 2020;8(1):143-147.
- Abu El-Hamd M, Hegazy EM. Comparison of the clinical efficacy of daily use of L-arginine, tadalafil and combined L-arginine with tadalafil in the treatment of elderly patients with erectile dysfunction. Andrologia. 2020;52(7):e13640. PubMed
- Liao SY, Showalter MR, Linderholm AL, et al. l-Arginine supplementation in severe asthma. JCI Insight. 2020;5(13):e137777. PubMed
- Yousefi Rad E, Nazarian B, Saboori S, Falahi E, Hekmatdoost A. Effects of l-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials. J Integr Med. 2020;18(4):284-291. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
- Goto E. Effects of prenatal oral L-arginine on birth outcomes: a meta-analysis. Sci Rep 2021;11(1):22748. PubMed
- Monari F, Menichini D, Pignatti L, Basile L, Facchinetti F, Neri I. Effect of L-arginine supplementation in pregnant women with chronic hypertension and previous placenta vascular disorders receiving Aspirin prophylaxis: a randomized control trial. Minerv PubMed
- Li H, Liu Q, Zou Z, et al. L-arginine supplementation to mitigate cardiovascular effects of walking outside in the context of traffic-related air pollution in participants with elevated blood pressure: A randomized, double-blind, placebo-controlled trial. PubMed
- Shiraseb F, Asbaghi O, Bagheri R, Wong A, Figueroa A, Mirzaei K. The Effect of L-arginine Supplementation On Blood Pressure in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Clinical Trials. Adv Nutr 2021. PubMed
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