L-Citrulline 1500 mg Ingredients & Drug Interactions
by NusaPure
What is this page for?
First and foremost: checking L-Citrulline 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Citrulline 1500 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Citrulline 1500 mg by NusaPure
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline 1500 mg by NusaPure — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Citrulline 1500 mg by NusaPure
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
NusaPure L-Citrulline contains one active ingredient: L-Citrulline DL-Malate at 1500 mg per capsule. L-citrulline is an amino acid your body uses to make another amino acid called L-arginine, which plays a role in widening blood vessels and blood flow.
The capsule also contains inactive ingredients — cellulose, silica, magnesium stearate, and rice flour — which are fillers and binders that give the capsule its form.
Does it work?
Moderate evidence
L-citrulline is possibly effective for athletic performance — the evidence suggests it may offer some benefit for exercise capacity or endurance. For sarcopenia (age-related muscle loss), the evidence leans toward it being possibly ineffective.
For cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (a fatty liver condition), and dementia, there isn't enough reliable evidence yet to say whether L-citrulline works.
How safe is it?
Well-documented data
L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal — stomach discomfort, heartburn, and general digestive upset.
A small number of patients with pulmonary hypertension reported cough, though this was rare. There is not enough safety data to recommend L-citrulline during pregnancy, so it's best to avoid it if you're pregnant.
Safety while breastfeeding is also unknown, so supplemental use should be avoided then too. Talk with your doctor or pharmacist about your individual situation.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking L-citrulline if you use blood pressure medications (antihypertensives) or erectile dysfunction drugs (PDE-5 inhibitors like sildenafil). Both carry Moderate-severity interaction risks centered on blood pressure drop.
Use the medication search tool on this page to verify your prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
L-citrulline might appeal to you if you're looking to support athletic performance, since the evidence points to a possible benefit there. If you take blood pressure medication or erectile dysfunction drugs, you'll want to clear this with your doctor or pharmacist first, because the blood-vessel widening effect can add to theirs.
Pregnant or breastfeeding? There isn't enough safety data — check with your healthcare provider.
Run your exact medications through the interaction checker on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Citrulline 1500 mg, straight from the product label.
| Brand | NusaPure |
|---|---|
| Barcode (UPC) | X001WMUXWB |
| Net contents | 180 Veg Cap(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 246702 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Citrulline 1500 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline DL-Malate | 1500 mg | -- |
Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Take three (3) capsules daily, preferably with a meal.
Precautions
Warning: For adults only.
If you are pregnant, nursing or taking any medications (especially blood pressure medications and nitrates or other vasodilating drugs), or have a medical condition (especially abnormal blood pressure), consult your doctor before use.
Do not exceed recommended dosage.
Keep out of reach of children.
Allergen Information: Contains no artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat. Produced in a GMP facility that processes other ingredients containing these allergens.
Storage
Store in cool dry place. Avoid excessive heat or moisture.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility
Manufactured in a cGMP Inspected Facility
Formulation
GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility
Assembled in USA Tested Supports healthy muscle mass & recovery Supports increased stamina & energy levels Supports a healthy immune system Max Strength
Allergen Information: Contains no artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
Natural color variation may occur in this product.
Formula
L-Citrulline 1500 mg per serving
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Citrulline 1500 mg by NusaPure label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Citrulline 1500 mg by NusaPure
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-Citrulline DL-Malate
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline DL-Malate monograph & interactionsOther (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.
L-Citrulline 1500 mg by NusaPure Drug Interactions
HelloPharmacist Interaction Report
NusaPure L-Citrulline 1500 mg can interact with blood pressure medications (antihypertensives) and erectile dysfunction drugs (phosphodiesterase-5 inhibitors, or PDE-5 inhibitors).
Both are Moderate-severity interactions. L-citrulline converts to L-arginine in your body, which widens your blood vessels — and that effect can add to what these drugs are already doing.
Read the full breakdown — every affected drug type, severity by severity
With blood pressure medications, the concern is that L-citrulline might lower your pressure further than intended, raising the risk of excessively low blood pressure (hypotension). A review of five small studies suggests that doses of 3–6 grams daily may have done this, though the data isn't conclusive.
With PDE-5 inhibitors like sildenafil (Viagra), the same additive blood-vessel widening and blood pressure drop is the worry.
Although one ingredient is present, it touches a lot of individual medications across these two categories. Altogether, these interactions span 178 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you start L-citrulline.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Citrulline 1500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Citrulline 1500 mg interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Citrulline 1500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate
MoexiprilUnivasc
How Moexipril interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Moexipril interactionMoxonidinePhysiotens
How Moxonidine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Moxonidine interactionNadololCorgard, Nadolol
How Nadolol interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nadolol interactionNebivololBystolic, Nebilet
How Nebivolol interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nebivolol interactionNebivolol Hydrochloride, ValsartanByvalson
How Nebivolol Hydrochloride, Valsartan interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nebivolol Hydrochloride, Valsartan interactionNicardipineCardene, Cardene IV, Cardene SR
How Nicardipine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nicardipine interactionNifedipineAdalat, Adalat CC, Adalat LA, Adalat PA, Adalat Retard, Adalat XL +15 more
How Nifedipine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nifedipine interactionNimodipineNimotop, Nymalize
How Nimodipine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nimodipine interactionNisoldipineSular
How Nisoldipine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nisoldipine interactionNitroprussideNitropress
How Nitroprusside interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Nitroprusside interactionOlmesartan MedoxomilBenicar, Olmesartan Medoxomil
How Olmesartan Medoxomil interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Olmesartan Medoxomil interactionOxprenololSlow Trasicor, Trasicor
How Oxprenolol interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Oxprenolol interactionPargylineEutonyl
How Pargyline interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Pargyline interactionPenbutolol SulfateLevatol
How Penbutolol Sulfate interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Penbutolol Sulfate interactionPerindopril Arginine, AmlodipinePrestalia
How Perindopril Arginine, Amlodipine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Perindopril Arginine, Amlodipine interactionPerindopril ErbumineAceon
How Perindopril Erbumine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Perindopril Erbumine interactionPhenoxybenzamineDibenzyline
How Phenoxybenzamine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Phenoxybenzamine interactionPindololPindol, Visken
How Pindolol interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Pindolol interactionPolythiazideRenese
How Polythiazide interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Polythiazide interactionPolythiazide, PrazosinMinizide
How Polythiazide, Prazosin interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Polythiazide, Prazosin interactionPolythiazide, ReserpineRenese R
How Polythiazide, Reserpine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Polythiazide, Reserpine interactionPrazosinMinipress, Prazin, Prazo
How Prazosin interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Prazosin interactionPropranololAngilol, Bedranol SR, Beta Prograne, Half Beta Prograne, Half-Inderal LA, Inderal +6 more
How Propranolol interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Propranolol interactionPropranolol HydrochlorideHemangeol
How Propranolol Hydrochloride interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Propranolol Hydrochloride interactionQuinaprilAccupril, Accupro
How Quinapril interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Quinapril interactionQuinethazoneHydromox
How Quinethazone interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Quinethazone interactionQuinethazone, ReserpineHydromox R
How Quinethazone, Reserpine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Quinethazone, Reserpine interactionRamiprilAltace
How Ramipril interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Ramipril interactionRescinnamineModeril
How Rescinnamine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Rescinnamine interactionReserpineSandril, Serpasil
How Reserpine interacts with L-Citrulline 1500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrulline Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline Dl-malate + Reserpine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Citrulline 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline DL-Malate
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for L-Citrulline 1500 mg, from the product label.
NusaPure
See all NusaPure products- Name
- Gmax Central LLC
- Street Address
- 4700 Millenia Boulevard, Suite 175 PMB 92909
- City
- Orlando
- State
- FL
- ZipCode
- 32839
L-Citrulline 1500 mg by NusaPure: Common Questions
Does L-Citrulline 1500 mg by NusaPure interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take L-citrulline if I'm pregnant or breastfeeding?
What are the most common side effects?
Does L-citrulline actually help with exercise?
Is this product tested for long-term safety?
What is L-Citrulline DL-Malate?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Citrulline 1500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Citrulline 1500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Citrulline 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC