L-Histidine HCl Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Histidine HCl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Histidine HCl is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Histidine HCl by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Histidine Hydrochloride, an amino acid (one of the building blocks your body uses to make proteins). L-Histidine itself is found naturally in protein-rich foods, and your body uses it for a range of functions including immune regulation and the production of histamine, a compound involved in inflammation and allergic responses.
Does it work?
Moderate evidence
The evidence for L-histidine is mixed and incomplete. It's rated possibly effective for cholera.
For several other conditions — atopic dermatitis (eczema), kidney failure, and rheumatoid arthritis (RA) — there isn't enough reliable evidence in our data to rate how well it works. If you're considering it for one of those uses, talk with your doctor about whether the current evidence supports a trial.
How safe is it?
Some data gaps
L-Histidine is likely safe in the amounts you'd eat in food as part of a normal diet. The safety data on supplement doses, though, isn't well established — the doses studied in research are limited and not as thoroughly reviewed as prescription medications.
The facts advise caution with supplemental amounts. There are no adverse effects documented in our data.
For pregnancy and lactation, the safety data rates L-histidine as likely safe. If you're pregnant or breastfeeding and wondering whether to take this supplement, that's a conversation to have with your own doctor or pharmacist, who can weigh it against your individual situation.
Meds to double-check
No known interactions
No interactions are documented in our data for L-histidine. That doesn't mean interactions can't happen — it means we don't hold a documented interaction in our monograph.
If you take any medications, mention this supplement to your own pharmacist or doctor before you begin, so they can review it against your exact drug regimen.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.
L-Histidine HCl is a single amino acid with limited established effectiveness and incomplete safety data at supplement doses. It may be worth a trial if your doctor recommends it for a specific condition, but the evidence is sparse.
Check with your own doctor or pharmacist before you start, especially if you have a medical condition or are pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Histidine HCl, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000J41BKB |
| Net contents | 1 kg; 35.3 oz |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 312161 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Histidine HCl by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Histidine Hydrochloride | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & pure bulk supplements
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once daily, or as directed by a physician.
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
General Statements
Use an accurate milligram scale. New
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Histidine HCl by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Histidine HCl by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.
L-Histidine Hydrochloride
No knowninteractions
Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...
L-Histidine Hydrochloride monograph & interactionsL-Histidine HCl by BulkSupplements.com Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Histidine HCl. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Histidine HCl, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
L-Histidine HCl by BulkSupplements.com: Common Questions
Does L-Histidine HCl by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-histidine, and what does it do in my body?
Is this supplement safe to take while I'm pregnant or breastfeeding?
Does L-histidine actually work, or is there evidence it helps with any conditions?
Are there any side effects I should know about?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Histidine HCl is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Histidine HCl’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Histidine HCl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC