L-Lysine Ingredients & Drug Interactions
by XYMOGEN
What is this page for?
First and foremost: checking L-Lysine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Lysine is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Lysine by XYMOGEN
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Lysine by XYMOGEN — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Lysine by XYMOGEN
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-Lysine, an amino acid your body uses to build proteins and support various functions. The capsule also contains inactive ingredients—HPMC, stearic acid, microcrystalline cellulose, magnesium stearate, and silica—which are fillers and binders that help form and stabilize the capsule.
Does it work?
Couldn't assess
L-Lysine is possibly effective for cold sores (herpes labialis) according to the evidence we have on file. For other uses listed—child growth, pressure ulcers, and diabetic foot ulcers—the evidence is insufficient to rate whether it works.
How safe is it?
Well-documented data
L-Lysine is generally well tolerated at typical doses. At high amounts, it may cause stomach upset, abdominal pain, diarrhea, or indigestion; long-term safety at higher doses isn't well studied.
There's one rare case report of it being linked to kidney inflammation progressing to chronic kidney disease, though this is not established as a common risk. Supplement safety in pregnancy and while breastfeeding hasn't been well studied—lysine from food is fine, but if you're pregnant or nursing, check with your doctor before taking this supplement to decide what's right for you.
Meds to double-check
Minor interactions only
If you take a 5-HT4 agonist (a medication that helps move food through your stomach or bowels), L-Lysine may reduce how well it works. Check with your doctor or pharmacist before combining them.
Altogether, these interactions span 1 individual medication.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
L-Lysine may help with cold sores if you're looking for evidence-based support. It's generally well tolerated, but high doses and long-term use aren't well studied.
If you're pregnant, breastfeeding, or take any medications—especially those for GI motility—talk it over with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Lysine, straight from the product label.
| Brand | XYMOGEN |
|---|---|
| Net contents | 90 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2012 |
| DSLD ID | 6136 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Lysine by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Lysine | 1000 mg | -- |
Other ingredients: HPMC, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
DIRECTIONS: Preferably on an empty stomach, take one to two capsules three times a day, or as directed by your healthcare practitioner.
Precautions
Keep out of reach of children.
Avoid if allergic to any ingredient.
CAUTIONS: Consult your healthcare practitioner before use.
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
STORAGE: Keep tightly closed in a cool, dry place.
General Statements
An Essential Amino Acid
This package is completely recyclable (recycle)
Exclusive Professional Formulas • Pharmaceutical Grade • Professional Use Only
General
TC# E0670901 REV. 060711
Brand IP Statement(s)
XYMOGEN 2011
All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.
L-Lysine is an amino acid essential in human physiology. Lysine is vital for normal growth and for the manufacture of collagen, a substance important for healthy skin, bones, tendons, and cartilage. Supplemental lysine may be appropriate for individuals on a high-arginine diet.*
Formulation
DOES NOT CONTAIN: Wheat, gluten, corn protein, yeast, soy, animal or dairy products, artificial colors, sweeteners, or preservatives.
Seals/Symbols
VEGETABLE CAPSULES
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Lysine by XYMOGEN label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Lysine by XYMOGEN
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
L-Lysine
Interacts with1 drug
Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...
L-Lysine monograph & interactionsOther (inactive) ingredients: HPMC, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
L-Lysine by XYMOGEN Drug Interactions
HelloPharmacist Interaction Report
XYMOGEN's L-Lysine has one documented interaction: it may reduce the effects of 5-HT4 agonists (a class of medications that work on serotonin receptors to help with certain GI issues).
Animal research suggests lysine acts as a partial blocker of the 5-HT4 receptor, which could theoretically lower how well these drugs work. The interaction is rated Minor.
Read the full breakdown — every affected drug type, severity by severity
Although we've identified this one medication type, the interaction data for L-Lysine is limited. If you take a 5-HT4 agonist or any other prescription medication, run it through the checker on this page or talk it over with your doctor or pharmacist before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Lysine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Lysine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in L-Lysine interact with drugs. Each result below shows which ingredient is responsible. L-Lysine
TegaserodZelnorm
How Tegaserod interacts with L-Lysine — through 1 ingredient. Tap an ingredient for the detail:
L-lysine5-ht4 Agonists Minor
Interaction Summary
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Read the full L-lysine + Tegaserod interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Lysine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Lysine
5-Ht4 Agonists
Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.
Brand information
Manufacturer and brand details for L-Lysine, from the product label.
XYMOGEN
See all XYMOGEN products- Name
- XYMOGEN Exclusive Professional Formulas
- Street Address
- 725 S. Kirkman Rd.
- City
- Orlando
- State
- FL
- ZipCode
- 32811
- Phone Number
- 800-647-6100
- Web Address
- www.xymogen.com
L-Lysine by XYMOGEN: Common Questions
Does L-Lysine by XYMOGEN interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-Lysine actually work for cold sores?
Can I take this if I'm pregnant?
What side effects might I notice?
Can I breastfeed while taking this?
Is there anything else in this capsule besides the lysine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Lysine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Lysine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Lysine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lysine 7 references
- Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
- McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
- DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
- Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
- Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC