L-Threonine 500 mg Ingredients & Drug Interactions
by Vitamatic
What is this page for?
First and foremost: checking L-Threonine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Threonine 500 mg is a dietary supplement by Vitamatic with 1 active ingredient. Its ingredients are commonly taken for general amino acid/protein support, muscle and tissue health, immune support.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Threonine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Threonine 500 mg by Vitamatic
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Threonine 500 mg by Vitamatic — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Threonine 500 mg by Vitamatic
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-threonine, an amino acid. Amino acids are building blocks your body uses to make proteins and perform other critical functions.
The capsule also holds a few inactive ingredients — hypromellose, silicon dioxide, magnesium stearate, and microcrystalline cellulose — which are fillers and binders that hold the capsule together.
Does it work?
Couldn't assess
The evidence for L-threonine is limited. For amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), it's rated possibly ineffective.
For multiple sclerosis, familial spastic paraparesis, and spasticity, we don't have enough reliable evidence to say whether it works. If you're considering this supplement for one of these conditions, talk it over with your doctor — they can advise based on what's worked for similar patients and your own health picture.
How safe is it?
Well-documented data
Threonine from food is well tolerated, but supplement safety at higher doses hasn't been well studied. The most common side effects reported in people who've taken threonine are headache and mild stomach upset, including diarrhea, gas, or constipation — generally minor and infrequent.
There isn't enough data on supplement use during pregnancy or breastfeeding to know whether it's safe, even though dietary amounts are fine. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this supplement.
Meds to double-check
Major interaction found
Before you start this supplement, double-check with your doctor or pharmacist if you take an NMDA antagonist — threonine may lower how well it works. Beyond that, use the medication checker on this page to see if we have interaction data for your other prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
L-threonine may be worth considering if you have one of the spastic or neurological conditions listed and your doctor thinks it could help — but the evidence is thin. The biggest thing to watch: if you take an NMDA antagonist, check with your doctor or pharmacist first.
Otherwise, it's generally well tolerated, though headache and mild digestive upset can happen.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Threonine 500 mg, straight from the product label.
| Brand | Vitamatic |
|---|---|
| Barcode (UPC) | 810078471172 |
| Net contents | 120 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 22, 2023 |
| DSLD ID | 283032 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Threonine 500 mg by Vitamatic, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Threonine | 500 mg | -- |
Other ingredients: Hypromellose, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Caution: Consult with your healthcare provider if you are pregnant, nursing, taking any medications or planning any medical procedures.
Do not exceed the recommended dose. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.
Do not use if safety seal is broken or missing.
Keep out of reach of children.
Storage
Store in a cool, dry place.
Formulation
Free of sugar, starch, sodium, yeast, soy, corn, wheat, egg, artificial colors, flavors, & preservatives.
Essential amino acid Supports healthy liver function & normal wound healing
Non GMO
FDA Disclaimer Statement
These statements have not been evaluated by the food and Drug Administration. This product s not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
GMP Good Manufacturing Practice Certified Made in U.S.A.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take one (1) capsule daily preferably before a meal or as directed by your qualified healthcare provider.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Threonine 500 mg by Vitamatic label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Threonine 500 mg by Vitamatic
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
L-Threonine
Interacts with3 drugs
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...
L-Threonine monograph & interactionsOther (inactive) ingredients: Hypromellose, Silicon Dioxide, Magnesium Stearate, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.
L-Threonine 500 mg by Vitamatic Drug Interactions
HelloPharmacist Interaction Report
Vitamatic L-Threonine 500 mg does interact with medications through its single active ingredient, L-threonine.
The most serious concern is with NMDA antagonists (a class of medications used for certain neurological and pain conditions). Threonine raises glycine levels in your central nervous system, and glycine enhances how NMDA receptors work — which means threonine may reduce the intended effect of these medications.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 3 individual medications. If you take an NMDA antagonist, talk with your doctor or pharmacist before starting this supplement to make sure it won't interfere with your treatment.
Beyond that, you'll want to check the search tool on this page for your exact medications — we may not have complete interaction data for every drug out there, but this will show you what we know about your specific prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Threonine 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Threonine 500 mg interact with 3 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Threonine 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Threonine
MemantineEbixa
How Memantine interacts with L-Threonine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine interactionMemantine HydrochlorideNamenda
How Memantine Hydrochloride interacts with L-Threonine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine Hydrochloride interactionMemantine, DonepezilNamzaric
How Memantine, Donepezil interacts with L-Threonine 500 mg — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine, Donepezil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Threonine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Threonine
Nmda Antagonists
Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.
Brand information
Manufacturer and brand details for L-Threonine 500 mg, from the product label.
Vitamatic
See all Vitamatic products- Name
- Vitamatic
- Street Address
- PO Box 406
- City
- Raritan
- State
- NJ
- ZipCode
- 08869
- Phone Number
- 1-973-400-9165
- Web Address
- www.vitamaticusa.com
L-Threonine 500 mg by Vitamatic: Common Questions
Does L-Threonine 500 mg by Vitamatic interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-threonine?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I get?
Does it really work for ALS or MS?
What are the inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Threonine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Threonine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Threonine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Threonine 4 references
- Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
- Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
- Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
- Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC