L-Threonine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Threonine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Threonine is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for general amino acid/protein support, muscle and tissue health, immune support.Based on those ingredients, 3 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Threonine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Threonine by BulkSupplements.com
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Threonine by BulkSupplements.com — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Threonine by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-threonine, an amino acid your body uses to build proteins and support various functions. L-threonine is provided in powder form, with no inactive fillers or other ingredients added.
Does it work?
Couldn't assess
The evidence for L-threonine is mixed and limited. For amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), it's rated possibly ineffective.
For multiple sclerosis, spasticity, and familial spastic paraparesis, the evidence isn't strong enough to rate. The data we hold doesn't establish its effectiveness for these conditions.
How safe is it?
Well-documented data
Threonine from food is fine, but supplement safety at higher doses hasn't been well studied. Headaches have been reported in people taking threonine supplements, and some experience mild gastrointestinal upset, including diarrhea, gas, or constipation.
For pregnancy and breastfeeding, there isn't enough data to know whether supplements are safe — amounts from food are normal, but higher-dose supplements haven't been studied in these situations. Talk with your doctor or pharmacist before taking this if you're pregnant or breastfeeding.
Meds to double-check
Major interaction found
Check your exact medications against the tool on this page if you take an NMDA antagonist — L-threonine may reduce its effect. These are the interactions we have data for in our records.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
L-Threonine may be worth considering if your doctor suggests it for a specific condition, but the evidence for most uses is weak or lacking. The main caution is NMDA antagonists — if you take one, check with your pharmacist first.
Because supplement safety at higher doses isn't well studied, this is a good one to discuss with your healthcare provider.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Threonine, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Barcode (UPC) | X000IOD0FV |
| Net contents | 1 Kilogram(s); 35.3 Ounce(s); 2.2 Pound(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2024 |
| DSLD ID | 312279 |
| Product type | Amino Acid/protein |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Threonine by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Threonine | 500 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
BulkSupplements.com Clean & Pure Bulk Supplements
Formulation
Free of: Added sugar, soy, dairy, yeast, gluten, additives
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 500 mg (about 1/5 tsp) once daily, or as directed by a physician.
General Statements
Use an accurate milligram scale.
New
Storage
Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place
FDA Disclaimer Statement
Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.
Precautions
Always consult a physician before taking any dietary supplement.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Threonine by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Threonine by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.
L-Threonine
Interacts with3 drugs
Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a norma...
L-Threonine monograph & interactionsL-Threonine by BulkSupplements.com Drug Interactions
HelloPharmacist Interaction Report
L-Threonine by BulkSupplements.com does interact with one class of medications.
The main concern is NMDA antagonists (a type of drug that blocks a specific brain receptor). Threonine raises glycine levels in your central nervous system, and glycine activates NMDA receptors — this means threonine may counteract what these medications are trying to do.
Altogether, these interactions span 3 individual medications.
Read the full breakdown — every affected drug type, severity by severity
If you take an NMDA antagonist, check your exact medication against the tool on this page before starting threonine. Your doctor or pharmacist can help you decide whether it's safe to use them together.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Threonine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Threonine interact with 3 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Threonine interact with drugs. Each result below shows which ingredient is responsible. L-Threonine
MemantineEbixa
How Memantine interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine interactionMemantine HydrochlorideNamenda
How Memantine Hydrochloride interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine Hydrochloride interactionMemantine, DonepezilNamzaric
How Memantine, Donepezil interacts with L-Threonine — through 1 ingredient. Tap an ingredient for the detail:
L-threonineNmda Antagonists Major
Interaction Summary
Theoretically, threonine might decrease the effects of NMDA antagonists.
Read the full L-threonine + Memantine, Donepezil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Threonine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Threonine
Nmda Antagonists
Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.
Brand information
Manufacturer and brand details for L-Threonine, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Rd
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
L-Threonine by BulkSupplements.com: Common Questions
Does L-Threonine by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-threonine actually work for ALS or multiple sclerosis?
What are the side effects?
Is it safe to take L-threonine supplements during pregnancy or breastfeeding?
Why is there a warning about NMDA antagonists?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Threonine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Threonine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Threonine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Threonine 4 references
- Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
- Lee A, Patterson V. A double blind study of L-threonine in patients with spinal spasticity. Acta Neurol Scand 1993;88:334-8. PubMed
- Blin O, Pouget J, Aubrespy G, et al. A double-blind placebo controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol 1992;239:79-81.
- Roufs JB. L-threonine as a symptomatic treatment for amyotrophic lateral sclerosis (ALS). Med Hypotheses 1991;34:20-3. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC