Interactions on record — worth a quick check against your medications. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

LeanCare Ingredients & Drug Interactions

by Himalaya

LeanCare label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LeanCare against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LeanCare is a dietary supplement by Himalaya with 10 active ingredients. Its ingredients are commonly taken for blood sugar control, boosting breast milk supply, high cholesterol.Based on those ingredients, 1,273 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema extract, Guggul, Garcinia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against LeanCare by Himalaya

Ask about any prescription or over-the-counter medication and we check it for interactions with LeanCare by Himalaya — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of LeanCare by Himalaya

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Proprietary Herbal Blend” is a proprietary blend — the label gives one combined amount (650 mg) without saying how much of each component you get.

LeanCare contains 10 ingredients, including fenugreek, fenugreek extract, gymnema, gymnema extract, guggul, guggul extract, garcinia (listed twice), chebulic myrobalan, and chebulic myrobalan extract. These are blended in a proprietary herbal formula designed for weight management.

The product also contains plant-based cellulose as an inactive ingredient (a capsule binder). Each active ingredient is traditionally used for metabolic support, though the strength and ratio of the blend are proprietary and not broken out on the label.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy weight with diet and exercise.
  • We looked for evidence on: Obesity, Metabolic syndrome, appetite suppression, carbohydrate cravings, metabolic support.
  • The closest evidence on file: Guggul is rated "Possibly Ineffective" for Obesity (Natural Medicines).
  • Also on file: Fenugreek is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.
  • Also on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for these ingredients is mixed and often limited. Fenugreek and fenugreek extract are rated possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea (menstrual pain), and diabetes.

Gymnema, gymnema extract, guggul, and guggul extract are all rated insufficient reliable evidence to rate for their primary uses—meaning the research doesn't yet establish whether they work for obesity, diabetes, or prediabetes. Garcinia and garcinia are also rated insufficient reliable evidence to rate for obesity, athletic performance, liver health, and cholesterol.

So while some ingredients show promise for specific conditions, we don't have solid evidence that LeanCare itself will deliver those benefits.

The evidence, ingredient by ingredient Fenugreek Gymnema Guggul Garcinia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fenugreek and its extract are generally well tolerated in food amounts, but supplement doses may cause digestive upset—abdominal pain, bloating, diarrhea, nausea, and gas are most common. Rare severe allergic reactions including swelling of the throat and bronchospasm are possible.

If you're pregnant, avoid medicinal amounts of fenugreek (it's rated likely unsafe because it may affect the uterus and newborns may develop an unusual body odor). Breastfeeding appears possibly safe, though evidence is limited; discuss with your provider first.

Gymnema is generally well tolerated short-term but can lower blood sugar and product quality varies. Avoid it during pregnancy and breastfeeding due to insufficient safety data.

Guggul may cause digestive upset and skin reactions (ranging from mild itching to facial swelling)—avoid during pregnancy and breastfeeding. Garcinia is generally tolerated short-term, but rare reports of liver injury exist; avoid it during pregnancy and breastfeeding.

We could not check safety data for chebulic myrobalan.

Side effects, ingredient by ingredient Fenugreek Gymnema Guggul Garcinia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Guggul, Fenugreek, Garcinia, Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,274 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking LeanCare, double-check these medication types with your doctor or pharmacist: blood thinners and antiplatelet drugs (warfarin, clopidogrel, aspirin) due to moderate risk of bleeding; antidiabetes drugs (metformin, insulin, sulfonylureas) due to moderate risk of low blood sugar; blood pressure medications (metoprolol, propranolol, diltiazem) due to moderate risk of a drop in blood pressure; antidepressants and serotonergic drugs due to moderate risk of serotonin syndrome; anti-seizure drugs (phenytoin) due to moderate risk of reduced drug levels; and liver-metabolized drugs (those broken down by CYP1A2, CYP2C9, and CYP3A4 enzymes) due to potential changes in effectiveness. No interactions are documented for the chebulic myrobalan or chebulic myrobalan extract we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

LeanCare is a multi-ingredient weight-management supplement with some traditionally used herbs and mixed evidence for effectiveness. If you take blood thinners, blood pressure meds, antidiabetes drugs, antidepressants, or any prescription medication, check your exact drugs against our tool before starting—the ingredient interactions are real and may matter for your safety.

Talk with your own doctor or pharmacist before adding this to your routine, especially if you're pregnant, breastfeeding, or have liver or heart concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 20, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LeanCare, straight from the product label.

Brand Himalaya
Barcode (UPC) 605069020015
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 20, 2017
DSLD ID 80703
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LeanCare by Himalaya, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
605069020015
IngredientAmount% DV
Fenugreek0 NP--
Proprietary Herbal Blend650 mg--
Gymnema extract0 NP--
Chebulic Myrobalan extract0 NP--
Chebulic Myrobalan0 NP--
Fenugreek extract0 NP--
Guggul0 NP--
Guggul extract0 NP--
Gymnema0 NP--
Garcinia0 NP--
Garcinia0 NP--

Other ingredients: Plant Based Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Ayurveda believes maintaining a healthy weight is possible by fortifying our mind-body connection in the form of willpower, individual choice and empowered digestion. The act of consciously changing dietary choices and increasing activity levels reestablishes the communication between the mind's goals and the body's needs.

cGMP

Our cartons are made from 100% recycled fibers, including 40% post-consumer material. Our glass bottles contain at least 48% recycled content.

Happiness through wellness

Crafting traditional medicines based on Ayurveda, a 5,000 year old science that believes the journey back to wholeness begins with nurturing the capacity for joy.

Trusting the gifts of nature and the irreplaceable relationship between the plant and its native soil for consistent healing properties.

Contributing to the wellness of the earth by teaching our family of farmers to grow native plants sustainably on their land and reduce the demand on the local environment.

Building communities by advocating women in farming, protecting fair prices, providing maternal health, sponsoring clinical services and offering school wellness programs.

Believing that if wellness is the path to happiness, we must contribute to the wellness of all things. Wellness of people, wellness of the environment, wellness of our communities.

Family owned for more than 85 years

Since 1930

Promotes weight management Supports metabolism with diet & exercise

1 month supply

Mfg. Lic. No. AUS-83

Product of India

Brand IP Statement(s)

The ancient texts of Ayurveda identified plants like Garcinia and Gymnema, both included in LeanCare, that can support digestion and metabolism to maintain normal weight along with diet and exercise.

Formula

Featured Herbs On Front: Garcinia (fruit), Gymnema (leaves) & Guggul (crystallized resin)

Includes Garcinia, Gymnema & Guggul

Formulation

Gluten free

Vegan friendly

Wheat Corn Soy Dairy

No ingredients of animal origin

Non-GMO Gluten free

General

HUS-5033353

Seals/Symbols

Non GMO Project Verified nongmoproject.org

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: Adults take 2 capsules twice daily with meals.

Precautions

Caution: As with any supplement, consult a healthcare practitioner before use if you are pregnant, nursing, taking medication, have a medical condition or are planning any medical procedure.

Discontinue use and consult a healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LeanCare by Himalaya label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LeanCare label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LeanCare by Himalaya

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Herbal Blend

650 mg per serving

Other (inactive) ingredients: Plant Based Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

LeanCare by Himalaya Drug Interactions

Want to check YOUR meds against LeanCare?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,273Drugs
1,159 Moderate 114 Minor

Ingredients driving the most interactions

Gymnema extract 851
Guggul 757
Garcinia 704
Fenugreek 389

Individual Drug Interactions

The ingredients in LeanCare interact with 1,273 drugs. Click any drug to see the details.

4 of the 10 ingredients in LeanCare interact with drugs. Each result below shows which ingredient is responsible. Gymnema extract Guggul Garcinia Fenugreek

Each ingredient & the kinds of drugs it affects

For each ingredient in LeanCare with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema extract full monograph & interactions

Guggul9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
Guggul full monograph & interactions

Garcinia4 drug types · 704 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.

Likelihood Possible Evidence D
Garcinia full monograph & interactions

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LeanCare, from the product label.

Himalaya

See all Himalaya products
Name
The Himalaya Drug Company
City
Makali
State
Bangalore
ZipCode
562 162
Pharmacist Counseling Corner

LeanCare by Himalaya: Common Questions

Does LeanCare by Himalaya interact with any medications?
Yes. Based on its ingredients, LeanCare has a known interaction with 1,273 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LeanCare contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will LeanCare help me lose weight?
The evidence isn't clear. Guggul and garcinia are rated insufficient reliable evidence to rate for weight loss, meaning we don't yet have solid proof they work. Garcinia is actually rated possibly ineffective. The ingredients have been traditionally used for metabolic support, but the research doesn't back that claim yet.
Is it safe to take if I'm pregnant?
No. Fenugreek is rated likely unsafe in pregnancy because it may affect the uterus, and guggul is also rated likely unsafe for the same reason. Gymnema and garcinia don't have enough safety data during pregnancy, so they should be avoided too. Talk with your doctor before taking any supplement while pregnant.
Can I take this while breastfeeding?
Fenugreek is possibly safe while breastfeeding and is even used to boost milk supply, but evidence is limited—discuss it with your provider first. Gymnema, guggul, and garcinia don't have enough safety information, so they're best avoided. We hold no breastfeeding data for chebulic myrobalan.
What side effects might I experience?
Most commonly, digestive upset—bloating, diarrhea, nausea, and gas. Guggul may cause skin reactions like rash or itching, usually dose-dependent. Rare but serious side effects include severe allergic reactions (swelling, trouble breathing) and, with long-term use of garcinia, liver damage or hepatitis. Stop and call your doctor if you develop severe abdominal pain, jaundice, or trouble breathing.
Does LeanCare interact with my diabetes medication?
Yes—moderately. Both fenugreek and gymnema can lower blood sugar on their own, and when combined with diabetes drugs, that risk goes up. Garcinia may also lower blood sugar in theory, though it's not been proven in humans yet. If you take any diabetes medication, check your dose and blood sugar closely and talk with your doctor before starting this.
Does it interact with blood thinners?
Yes. Fenugreek, guggul, and garcinia may all increase bleeding risk when combined with anticoagulants like warfarin or antiplatelet drugs like aspirin and clopidogrel. If you take any blood thinner, ask your doctor or pharmacist before adding LeanCare.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LeanCare label
Go deeper

The Full Monographs Behind LeanCare’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph → Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph → Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph →
Sources

Sources & How We Checked

LeanCare's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 107 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fenugreek 30 references
  1. Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
  2. Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
  3. Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
  4. Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
  5. Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
  6. Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
  7. Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
  8. Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
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