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Dietary supplement

Lemon Balm Extract Ingredients & Drug Interactions

by Fresh Nutrition

Lemon Balm Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon Balm Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lemon Balm Extract is a dietary supplement by Fresh Nutrition with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon Balm Extract by Fresh Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Lemon Balm Extract by Fresh Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lemon Balm Extract by Fresh Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lemon balm extract. Lemon balm is a mint-family herb used traditionally for stress and sleep, and modern research has looked at it for cold sores and mood support.

The capsules themselves are vegetarian.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reduce stress and anxiety, promote sleep.
  • We looked for evidence on: Anxiety, Stress, Insomnia, restlessness, nervousness.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.

The evidence suggests lemon balm extract is possibly effective for cold sores (herpes labialis) and possibly effective for stress and depression. That means the research is promising but not yet conclusive — so it may help, but we can't guarantee it will work for everyone or that the effect is strong.

If you're considering it for one of those uses, talk with your doctor about whether it makes sense for your situation.

The evidence, ingredient by ingredient Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in healthy adults, though long-term safety and high-dose effects haven't been thoroughly studied. Side effects like dizziness and sedation have been reported, but they don't seem to happen more often than with placebo.

One rare case of heart rhythm changes was reported in a woman using a multi-ingredient product containing lemon balm, but it's unclear whether lemon balm itself was responsible. During pregnancy, there isn't enough reliable safety data, so it's best avoided unless your doctor advises otherwise.

While breastfeeding, safety information is limited — talk with your doctor before using.

Side effects, ingredient by ingredient Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use any CNS depressants — like sedatives, anti-anxiety medications, sleep aids, or any drug that makes you drowsy — because lemon balm might strengthen their effect. Also check if you take thyroid hormone replacement therapy, as lemon balm may reduce its effectiveness.

If you're on either type of medication, talk with your doctor or pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lemon Balm Extract may be worth considering if you're looking for support with cold sores, stress, or mood, and you don't take CNS depressants or thyroid medication. If you do take either of those drug types, check with your doctor or pharmacist first — the interactions are documented but manageable with their guidance.

For short-term use in healthy adults, it's generally well tolerated, but long-term safety hasn't been fully studied.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon Balm Extract, straight from the product label.

Brand Fresh Nutrition
Barcode (UPC) 851039008112
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242009
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon Balm Extract by Fresh Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
851039008112
IngredientAmount% DV
Lemon Balm extract600 mg--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Non GMO Gluten free Soy free

No artificial colors. No artificial flavors. No preservatives. Made with Non-GMO, all natural ingredients!

Quality Verified Third Party Tested For Quality And Purity To provide our consumers with complete confidence in our product quality, every batch is 3rd party tested for quality & purity.

Sourced from Mediterranean region Assist with stress & anxiety May calm the mind and help sleep May improve skin appearance May sharpen memory May support liver and blood sugar

Fresh Nutrition produces the most potent and highest quality Lemon Balm Extract. Our raw materials are carefully sourced and cultivated; contain no fillers, additives, and are manufactured domestically in a cGMP facility. Thank you for choosing Fresh!

Formula

Lemon Balm Lemon Balm is a perennial herb from the mint family with a gentle lemony fragrance. Native to Southern Europe and the Mediterranean, Lemon Balm has been used as far back as the Middle Ages to reduce stress and anxiety, promote sleep, improve appetite, and to ease pain and discomfort from indigestion.

Made with Non-GMO, all natural ingredients!

General Statements

Fresh Nutrition Our goal is to create high-quality natural products using both organic and responsibly sourced ingredients to optimize health and well-being.

All natural

Suggested/Recommended/Usage/Directions

Recommended Dosage Take three (3) capsules daily with sufficient water before a meal.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon Balm Extract by Fresh Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon Balm Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon Balm Extract by Fresh Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lemon Balm extract

Interacts with
264 drugs
600 mg per serving Form: Rosmarinic Acid

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm extract monograph & interactions

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon Balm Extract by Fresh Nutrition Drug Interactions

Want to check YOUR meds against Lemon Balm Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm extract 264

Individual Drug Interactions

The ingredients in Lemon Balm Extract interact with 264 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lemon Balm Extract interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon Balm Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon Balm Extract, from the product label.

Fresh Nutrition

See all Fresh Nutrition products
Name
Fresh Nutrition
Street Address
1601 Dove St
City
Newport Beach
State
California
ZipCode
92660
Web Address
www.fresh-nutrition.com
Pharmacist Counseling Corner

Lemon Balm Extract by Fresh Nutrition: Common Questions

Does Lemon Balm Extract by Fresh Nutrition interact with any medications?
Yes. Based on its ingredients, Lemon Balm Extract has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon Balm Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take lemon balm extract while pregnant?
The safety data isn't reliable enough, so it's best avoided during pregnancy unless your doctor advises otherwise. Talk with your doctor about your specific situation before taking it.
Is it safe to use while breastfeeding?
Safety information is limited. Talk with your doctor before using lemon balm while breastfeeding so you can make the best choice for you and your baby.
What is lemon balm used for?
Research suggests it may help with cold sores, stress, and depression — though the evidence is promising but not yet conclusive. It's traditionally been used as a calming herb.
Does it cause drowsiness?
Drowsiness and dizziness have been reported, but studies show they don't happen more often with lemon balm than with placebo. That said, lemon balm does seem to have a calming effect on the brain, so some people might feel more relaxed.
Can I take it with alcohol?
Research shows that using lemon balm with alcohol doesn't affect reaction time or cognitive performance in the way studied. Even so, combining any CNS depressant-type herb with alcohol is worth discussing with your doctor beforehand.
How long is it safe to take lemon balm extract?
It's generally well tolerated for short-term use, but long-term safety and effects of high doses haven't been well studied. Talk with your doctor about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon Balm Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon Balm Extract label
Go deeper

The Full Monographs Behind Lemon Balm Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Lemon Balm Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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