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Dietary supplement

Lemon Ingredients & Drug Interactions

by Zongle Therapeutics

Lemon label
See full label image
Liquid Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lemon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Lemon is a dietary supplement by Zongle Therapeutics with 1 active ingredient. Its ingredients are commonly taken for vitamin c source, digestive support, flavoring and aromatherapy.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Lemon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lemon by Zongle Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Lemon by Zongle Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lemon by Zongle Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lemon. The supplement also includes lemon oil as an inactive ingredient.

Lemon is a citrus fruit commonly consumed in food and beverages. When used in amounts beyond normal food intake — such as in concentrated supplements or essential oil form — its chemical composition changes and effects aren't as well understood.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cleansing, digestive and respiratory support.
  • We looked for evidence on: Respiratory tract infections, Kidney stones (nephrolithiasis), Digestive health, Throat health.
  • The closest evidence on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Lemon is rated "Insufficient Reliable Evidence To Rate" for Kidney stones (nephrolithiasis).

The evidence for lemon's effectiveness on conditions like hay fever, anxiety, respiratory tract infections, high blood pressure, and kidney stones is insufficient. We don't have reliable data to rate how well it works for these uses.

The evidence, ingredient by ingredient Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon as a food or drink in normal amounts is well tolerated. However, concentrated supplements or essential oils from lemon haven't been well studied and should only be used with your doctor's approval.

In a clinical trial, 60 mL of fresh lemon juice taken twice daily caused gastrointestinal side effects in a notable number of participants. About 21% experienced heartburn and 8% experienced upper abdominal pain (epigastralgia), compared to much lower rates in the placebo group.

A full safety evaluation of larger amounts hasn't been completed.

Side effects, ingredient by ingredient Lemon

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lemon.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take itraconazole (Sporanox), an antifungal medication, check with your doctor or pharmacist before using this lemon supplement — taking them together may raise itraconazole levels in your blood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Lemon as a food is generally well tolerated, but this supplement in concentrated form hasn't been extensively studied. If you take itraconazole or have a history of heartburn or stomach upset, talk with your doctor or pharmacist first.

They can help you decide whether this product fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lemon, straight from the product label.

Brand Zongle Therapeutics
Net contents 0.5 Fluid Ounce(s); 15 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 277110
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lemon by Zongle Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
250
IngredientAmount% DV
Lemon60 mg--

Other ingredients: Lemon Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic, topical or internal use.

For internal use dilute one drop in 4 fl. oz. of liquid.

Formulation

Powerful purifying cleansing agent Provides cleansing and digestive benefits Supports healthy respiratory function Uplifting and energizing

100% pure therapeutic grade Origin: Italy Bottled in USA

Artificial ingredients free GMO free Gluten free Preservatives free Paraben free

Vegan

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If you are pregnant, nursing, or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas. Avoid sunlight or UV rays for up to 12 hours after applying product.

Formula

Citrus limon

FDA Statement of Identity

Essential Oil Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lemon by Zongle Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lemon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lemon by Zongle Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container250 Amounts shown are per serving.

Lemon

Interacts with
1 drug
60 mg per serving

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it...

Lemon monograph & interactions

Other (inactive) ingredients: Lemon Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lemon by Zongle Therapeutics Drug Interactions

Want to check YOUR meds against Lemon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

Lemon 1

Individual Drug Interactions

The ingredients in Lemon interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Lemon interact with drugs. Each result below shows which ingredient is responsible. Lemon

Each ingredient & the kinds of drugs it affects

For each ingredient in Lemon with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
Lemon full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lemon, from the product label.

Zongle Therapeutics

See all Zongle Therapeutics products
Name
Zongle Therapeutics LLC
Web Address
www.zongletherapeutics.com
Pharmacist Counseling Corner

Lemon by Zongle Therapeutics: Common Questions

Does Lemon by Zongle Therapeutics interact with any medications?
Yes. Based on its ingredients, Lemon has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lemon contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have heartburn or a sensitive stomach?
Fresh lemon juice in medicinal amounts has caused heartburn and upper abdominal discomfort in a significant portion of people in clinical trials. If you have a history of these issues, talk with your doctor or pharmacist before starting this product.
Is lemon safe during pregnancy or while breastfeeding?
The product facts don't include specific safety information for pregnancy or breastfeeding. Since this is a concentrated supplement rather than food-amount lemon, discuss it with your doctor before use during either time.
What is lemon actually used for in this supplement?
The evidence for lemon's effectiveness on hay fever, anxiety, respiratory infections, high blood pressure, and kidney stones is insufficient — we don't have reliable data showing it works for these conditions.
Are there any other ingredients I should know about?
The supplement contains lemon oil as an inactive ingredient. The product facts advise that medicinal amounts and essential oil forms of lemon haven't been well studied, so approval from your doctor is recommended.
What side effects might I experience?
In normal food amounts, lemon is well tolerated. In larger medicinal doses, heartburn and upper abdominal pain are the most common side effects reported in trials, affecting a meaningful percentage of users.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lemon is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lemon label
Go deeper

The Full Monographs Behind Lemon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon

Interacts with 1 drug

Lemon is a common citrus fruit that is a good source of vitamin C and citric acid, and it is widely used in food, drinks, and home remedies. While it can support hydration and a healthy diet...

Read the full Lemon monograph →
Sources

Sources & How We Checked

Lemon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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