Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Leucine Agma Ingredients & Drug Interactions

by BPI Sports

Leucine Agma label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Leucine Agma against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Leucine Agma is a dietary supplement by BPI Sports with 2 active ingredients. Its ingredients are commonly taken for pre- and post-workout support, muscle pumps and exercise performance, cognitive support and mood.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agmatine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Leucine Agma by BPI Sports

Ask about any prescription or over-the-counter medication and we check it for interactions with Leucine Agma by BPI Sports — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Leucine Agma by BPI Sports

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Leucine Agma contains 2 active ingredients: leucine and agmatine. Agmatine is derived from the amino acid arginine and is included in this formula to support athletic and cognitive function.

The product also contains several inactive ingredients — pH-buffering agents, taurine, silica, acids for flavor, and sweeteners — that help stabilize and taste the powder.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agmatine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: muscle protein synthesis and anabolic support.
  • We looked for evidence on: Athletic performance, Muscle strength, muscle hypertrophy, lean mass gain, protein metabolism.
  • The closest evidence on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Agmatine is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence on agmatine for the conditions listed in our data—alcohol use disorder, Alzheimer disease, anxiety, athletic performance, autism spectrum disorder, and bipolar disorder—is insufficient to rate its effectiveness. We hold no effectiveness ratings for leucine in our data.

If you're considering this product for a specific purpose, talk with your doctor or pharmacist about what the science actually supports for your situation.

The evidence, ingredient by ingredient Agmatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agmatine appears generally well tolerated when used short-term in recommended amounts. Long-term safety in humans has not been well studied, so caution is warranted with extended use.

The most common side effects reported in small trials are diarrhea, indigestion (dyspepsia), and nausea — these typically appeared within a few days and resolved when people stopped taking it. Safety data is insufficient for pregnancy and breastfeeding, so the evidence advises against use during both.

We hold no safety data for leucine.

Side effects, ingredient by ingredient Agmatine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agmatine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use blood pressure medications (antihypertensives) — agmatine may lower blood pressure further and increase the risk of dangerously low readings. Also flag any diabetes medications (antidiabetes drugs) you take, as agmatine may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Leucine Agma is a two-ingredient powder that's generally well tolerated short-term but carries moderate interaction risks with blood pressure and diabetes medications. If you take either type of drug, check your exact medications with your pharmacist or doctor before starting this product.

Long-term safety isn't well established, so this is a conversation worth having with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Leucine Agma, straight from the product label.

Brand BPI Sports
Barcode (UPC) 851780006573
Net contents 4.23 oz.; 120 Gram(s)
Market status On market
Date entered into DSLD Mar 25, 2015
DSLD ID 43268
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Leucine Agma by BPI Sports, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
40
UPC/BARCODE
851780006573
IngredientAmount% DV
Leucine1.5 Gram(s)--
Agmatine250 mg--

Other ingredients: pH-Sorb(TM) Buffering Technology, Taurine, Silica, Citric Acid, Malic Acid, Resolver, Sucralose, Acesulfame-K

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

- ANABOLIC* - PUMPS* - N.O. SYNTHASE*

{chart} These POWERFUL Stacks when used together are designed to help promote the ultimate Anabolic physique.* WORKOUT DAYS NON-WORKOUT DAYS STACKING PROTOCOL PRE-WORKOUT POST-WORKOUT MORNING AFTERNOON BETA-ALKALINE(TM) {scoop}x1 20-30 MIN PRIOR {scoop}x1 CREATINE-ALKALINE(TM) {capsule}x2 PRIOR {scoop}x2 IMMEDIATELY AFTER {capsule}x2 GLUTA-ALKALINE(TM) {scoop}x1 {scoop}x1 {scoop}x1 LEUCINE AGMA (TM) {scoop}x1 {scoop}x1 {scoop}x1

L-Leucine is an essential amino acid that the body cannot synthesize on its own. Research shows that L-Leucine can help stimulate muscle protein synthesis and preserve muscle tissue.

Agmatine, in the preferred Agmatine Sulfate form, has shown greater potential than L-Arginine for nitric oxide synthase, in early stage work. Additionally, Agmatine has been suggested in the scientific literature to have other properties that could have direct benefits to athletes and bodybuilders, too.

References select isolated constituent parts, as it relates to analytical characterization of the same. When combined with a proper exercise and nutrition regimen. Statements based on early-stage independent 3rd party in vivo and / or in vitro model scientific research data findings for individual ingredients.

MAY EXPERIENCE: ANABOLIC ACTIVITY* NITRIC OXIDE SYNTHASE* INCREASED PUMPS* UNFLAVORED 40 SERVINGS

Please read entire label before use.

Formula

Leucine Agma(TM) is L-Leucine (including the exciting form, L-Leucine HCl) and Agmatine Sulfate.

This must-have CPS muscle building supplement also contains Agmatine, which is a novel analog of L-Arginine.

For enhanced nutrient uptake, the patent-pending pH Balanced Alkaline Buffering System pH-Sorb(TM) has been added, which is designed to directly influence the acidity level during metabolization, for optimal uptake and utilization.*

pH BUFFERED ANABOLIC N.O. SYNTHASE*

PRO LEVEL L-LEUCINE - LEUCINE HCL & AGMATINE

Precautions

Warnings: Not intended for use by persons under age 18.

Do not exceed recommended dose.

Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, you are pregnant, nursing or thinking about becoming pregnant.

KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.

Seals/Symbols

LABORATORY CERTIFIED Independent Third-Party

FDA Disclaimer Statement

*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) serving (1 scoop) with approximately 6 ounces of water or juice, or as directed by a qualified healthcare practitioner. Can be taken pre/intra/or post workout. On non-training days, take one (1) serving (1 scoop) first thing in the morning on an empty stomach.

General

Rev. 01-002-LPS003 11/13

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Leucine Agma by BPI Sports label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Leucine Agma label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Leucine Agma by BPI Sports

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Leucine

1.5 Gram(s) per serving Form: L-Leucine, Leucine Hydrochloride

Agmatine

Interacts with
258 drugs
250 mg per serving Form: Agmatine Sulfate

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most...

Agmatine monograph & interactions

Other (inactive) ingredients: PH-Sorb(TM) Buffering Technology, Taurine, Silica, Citric Acid, Malic Acid, Resolver, Sucralose, Acesulfame-K. These complete the product’s ingredient list but are not active constituents.

Interaction report

Leucine Agma by BPI Sports Drug Interactions

Want to check YOUR meds against Leucine Agma?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

Agmatine 258

Individual Drug Interactions

The ingredients in Leucine Agma interact with 258 drugs. Click any drug to see the details.

1 of the 2 ingredients in Leucine Agma interact with drugs. Each result below shows which ingredient is responsible. Agmatine

Each ingredient & the kinds of drugs it affects

For each ingredient in Leucine Agma with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agmatine2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggest that agmatine has mild hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that agmatine can modestly decrease heart rate and blood pressure.

Likelihood Possible Evidence D
Agmatine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Leucine Agma, from the product label.

BPI Sports

See all BPI Sports products
Web Address
www.bpisports.net
Pharmacist Counseling Corner

Leucine Agma by BPI Sports: Common Questions

Does Leucine Agma by BPI Sports interact with any medications?
Yes. Based on its ingredients, Leucine Agma has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Leucine Agma contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does agmatine do in this formula?
Agmatine is an amino acid compound included to support athletic and cognitive function. The evidence for it in conditions like athletic performance and anxiety is insufficient to rate, so we can't confirm how well it works for any specific use.
Can I use this if I'm pregnant or breastfeeding?
No. There isn't enough safety data for either pregnancy or breastfeeding, so the evidence advises against use during both. Talk with your doctor about safer options for your situation.
What side effects might I experience?
The most common are diarrhea, indigestion, and nausea. In small trials, these appeared within a few days of starting and went away when people stopped taking it. Short-term use appears well tolerated, but long-term safety hasn't been well studied.
Why can't you check leucine for interactions?
We hold no interaction data for leucine, so we can't verify whether it interacts with medications. Our agmatine data covers 258 individual drugs, but leucine remains unchecked in our system.
Is this product safe to use long-term?
Short-term use appears generally well tolerated. However, long-term safety in humans hasn't been well studied, so extended use warrants caution. Discuss duration of use with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Leucine Agma label
Go deeper

The Full Monographs Behind Leucine Agma’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agmatine

Interacts with 258 drugs

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and...

Read the full Agmatine monograph →
Sources

Sources & How We Checked

Leucine Agma's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agmatine 3 references
  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

See these in context on the Agmatine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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