LGD Elite Ingredients & Drug Interactions
What is this page for?
First and foremost: checking LGD Elite against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
LGD Elite is a dietary supplement by Blackstone Labs with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance and strength, body recomposition.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 4-((R)-2-[(R)-2,2,2-Trifluoro-1-Hydroxyethyl]Pyrrolidin-1-1-Yl)-2-TrifluoroMethyl)Benzonitrile. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against LGD Elite by Blackstone Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with LGD Elite by Blackstone Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
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HelloPharmacist Scorecard of LGD Elite by Blackstone Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
LGD Elite contains one active ingredient: ligandrol (also called LGD-4033), a SARM that's designed to bind to androgen receptors in muscle and bone. The capsule also contains inactive ingredients — rice flour, gelatin, magnesium stearate, stearic acid, and silica — which are fillers and binders.
Does it work?
Insufficient evidence
The evidence we hold doesn't establish that ligandrol works reliably for any of the purposes it's marketed for — athletic performance, muscle strength, cachexia (severe muscle wasting), or muscular dystrophy. All of those ratings are insufficient evidence to rate, meaning the published data doesn't support a clear yes or no.
How safe is it?
Well-documented data
This is the biggest concern: ligandrol is an unapproved investigational drug, not a legal dietary supplement. Case reports show liver injury linked to its use — the FDA has warned that supplements containing SARMs like ligandrol carry a risk of liver toxicity.
One case involved a 32-year-old who took 10 mg daily for just 2 weeks before developing signs of liver damage. Additionally, early studies show it may lower HDL cholesterol (the protective kind) even at very low doses.
If you're pregnant or breastfeeding, the safety data advises against it completely — hormonal SARMs can harm a developing baby, and it may pass into breast milk.
Meds to double-check
Moderate interaction found
Before taking LGD Elite, check with your doctor or pharmacist if you're on any hepatotoxic drugs (drugs that can harm the liver). Ligandrol may add to their liver-damaging effects.
Because ligandrol itself carries a documented risk of liver injury, anyone with liver disease or compromised liver function should avoid it entirely.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Ligandrol is an unapproved investigational drug with documented cases of liver injury tied to its use. The evidence doesn't show it works reliably for the conditions it's marketed for.
If you're considering taking it, talk honestly with your doctor or pharmacist first — especially if you have any liver concerns or take other medications that affect the liver.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about LGD Elite, straight from the product label.
| Brand | Blackstone Labs |
|---|---|
| Barcode (UPC) | 638458713540 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 25, 2018 |
| DSLD ID | 170794 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for LGD Elite by Blackstone Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| BSL LGD-Elite | 0 NP | -- |
| 4-((R)-2-[(R)-2,2,2-Trifluoro-1-Hydroxyethyl]Pyrrolidin-1-1-Yl)-2-TrifluoroMethyl)Benzonitrile | 3 mg | -- |
Other ingredients: Rice Flour, Gelatin, Magnesium Stearate, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions of usage: As a dietary supplement take 1 capsule two times per day with a meal. Do not exceed 2 capsules daily. Visit our website for additional information and guidance.
Precautions
Do not exceed 2 capsules daily.
Warning: Not for use by individuals under the age of 18 years.
Do not take without first consulting with a licensed healthcare provider. This product should not be taken by women. Do not take this product if you have been diagnosed with androgen-sensitive cancers, high cholesterol or hypertension.
Keep this product out of the reach of children.
Do not use if seal is damaged or missing.
Storage
Store in cool or dry place.
FDA Disclaimer Statement
Disclaimer: These Statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Maximum gains
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
LGD Elite by Blackstone Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in LGD Elite by Blackstone Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Other (inactive) ingredients: Rice Flour, Gelatin, Magnesium Stearate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
LGD Elite by Blackstone Labs Drug Interactions
HelloPharmacist Interaction Report
LGD Elite by Blackstone Labs contains ligandrol, a SARM (selective androgen receptor modulator) that we need to flag clearly: it's an unapproved investigational drug, not a legal dietary supplement, and it carries real safety concerns.
The one documented interaction is with hepatotoxic drugs (drugs that can harm the liver) — ligandrol may add to their liver-damaging effects, and case reports link ligandrol itself to liver injury.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 371 individual medications.
Before you take this product, talk with your doctor or pharmacist about any medications you're on, especially anything that affects your liver. If you'd like to check your specific drugs against the documented interactions, use the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against LGD Elite?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in LGD Elite interact with 370 drugs. Click any drug to see the details.
1 of the 1 ingredient in LGD Elite interact with drugs. Each result below shows which ingredient is responsible. 4-((R)-2-[(R)-2,2,2-Trifluoro-1-Hydroxyethyl]Pyrrolidin-1-1-Yl)-2-TrifluoroMethyl)Benzonitrile
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
How Acetaminophen, Doxylamine, Pseudoephedrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Doxylamine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Ibuprofen interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Meperidine interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with LGD Elite — through 1 ingredient. Tap an ingredient for the detail:
4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrileHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive hepatotoxic effects.
Read the full 4-((r)-2-[(r)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-1-yl)-2-trifluoromethyl)benzonitrile + Acetaminophen, Oxycodone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in LGD Elite with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
4-((R)-2-[(R)-2,2,2-Trifluoro-1-Hydroxyethyl]Pyrrolidin-1-1-Yl)-2-TrifluoroMethyl)Benzonitrile
Hepatotoxic Drugs
Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.
Brand information
Manufacturer and brand details for LGD Elite, from the product label.
LGD Elite by Blackstone Labs: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if LGD Elite is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind LGD Elite’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
LGD Elite's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Ligandrol 9 references
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
- Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
- Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
- Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
- Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC