Interactions on record — worth a quick check against your medications. Based on 7 of 8 ingredients. Check your meds →
Dietary supplement

Li Dan Pian Ingredients & Drug Interactions

by Plum Flower

Li Dan Pian label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Li Dan Pian against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Li Dan Pian is a dietary supplement by Plum Flower with 8 active ingredients. Its ingredients are commonly taken for inflammation, allergies, anxiety and sleep.Based on those ingredients, 1,304 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Scutellaria baicalensis, Rheum palmatum, Bupleurum chinense. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Li Dan Pian by Plum Flower

Ask about any prescription or over-the-counter medication and we check it for interactions with Li Dan Pian by Plum Flower — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Li Dan Pian by Plum Flower

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (1,140 mg) without saying how much of each component you get.

Li Dan Pian contains 8 ingredients total. The active ingredients include Baikal Skullcap (Scutellaria baicalensis), Rhubarb root (Rheum palmatum), Elecampane (Inula helenium), Honeysuckle (Lonicera japonica), Bupleurum (Bupleurum chinense), Isatis (Isatis indigotica), and two ingredients we cannot fully evaluate: Lysimachia christinae and Artemisia capillaris.

The product also contains several inactive ingredients — Microcrystalline Cellulose, Dextrin, Hypromellose, Polyethylene Glycol, and Magnesium Stearate — which serve as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Menopausal symptoms — rated "Possibly Effective" (Rhubarb) (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Rhubarb) (Natural Medicines).
  • On file: Psoriasis — rated "Possibly Effective" (Isatis) (Natural Medicines).

The evidence we hold on these ingredients doesn't establish strong effectiveness for any condition. Rhubarb shows possibly effective ratings for pancreatitis and menopausal symptoms.

Isatis shows a possibly effective rating for psoriasis. The remaining ingredients — Baikal Skullcap, Elecampane, Honeysuckle, Bupleurum, and the two ingredients we cannot check — either have insufficient reliable evidence or no established ratings in our data for their traditional uses in this formula.

The evidence, ingredient by ingredient Baikal Skullcap Rhubarb Elecampane Honeysuckle Bupleurum Yin Chen Isatis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, Baikal Skullcap and Rhubarb seem generally well tolerated, though adverse effects are possible. Baikal Skullcap may cause abdominal pain, constipation, diarrhea, nausea, or vomiting; rare serious effects include liver damage and a lung condition called hypersensitivity pneumonitis.

Rhubarb commonly causes cramping, diarrhea, nausea, or vomiting, and chronic use can deplete potassium and affect the kidneys. Elecampane can trigger allergic contact dermatitis and cause stomach upset.

Honeysuckle is generally used as a tea with few reported problems, though allergic reactions have been documented. During pregnancy, safety data are insufficient or advise against use for Baikal Skullcap, Rhubarb, Elecampane, Bupleurum, Honeysuckle, and Isatis.

Rhubarb is rated possibly unsafe in pregnancy. For breastfeeding, safety data are inadequate for all ingredients; avoid medicinal use while nursing.

Talk with your doctor or pharmacist if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Baikal Skullcap Rhubarb Elecampane Honeysuckle Bupleurum Yin Chen Isatis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Elecampane, Rhubarb, Yin Chen, Honeysuckle, Bupleurum, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,305 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Li Dan Pian, double-check with your pharmacist if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), blood pressure medications, diabetes drugs, heart medications (especially digoxin), lithium, thyroid or antithyroid medications, diuretics, corticosteroids, cyclosporine, sedating medications, or any drugs processed by your liver. Several ingredients also moderately interact with these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Li Dan Pian is a traditional herbal formula with modest evidence for effectiveness and multiple documented medication interactions — most notably with blood thinners, blood pressure drugs, diabetes medications, and liver-metabolized drugs. If you take any prescription medications, check them against the tool on this page before starting.

Pregnant or nursing individuals should talk with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Li Dan Pian, straight from the product label.

Brand Plum Flower
Barcode (UPC) 739934939123
Net contents 84 Tablet(s); 0.84 Oz(s); 23.9 Gram(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 210219
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Li Dan Pian by Plum Flower, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
21
UPC/BARCODE
739934939123
IngredientAmount% DV
Proprietary Extract Blend1140 mg--
Lysimachia christinae0 NP--
Scutellaria baicalensis0 NP--
Rheum palmatum0 NP--
Inula helenium0 NP--
Lonicera japonica0 NP--
Bupleurum chinense0 NP--
Artemisia capillaris0 NP--
Isatis indigotica0 NP--

Other ingredients: Microcrystalline Cellulose, Dextrin, Hypromellose, Polyethylene Glycol, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GMP Quality

FDA Statement of Identity

Herbal Dietary Supplement

Formulation

Plum Flower quality guarantee No pharmaceuticals or dyes Unsulfured preservative-free herbs when available

Formula

Scientifically authenticated herbs

General Statements

Microbial and heavy metal tested Produced at a Good Manufacturing Practices (GMP) certified factory

U.S. owned and operated since 1969 Made in China

Suggested/Recommended/Usage/Directions

Take 4 tablets 3 times daily or as directed by your health care practitioner

Precautions

Not for use during pregnancy Caution while nursing

Keep out of reach of children

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Li Dan Pian by Plum Flower label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Li Dan Pian label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Li Dan Pian by Plum Flower

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container21 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

1140 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Dextrin, Hypromellose, Polyethylene Glycol, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Li Dan Pian by Plum Flower Drug Interactions

Want to check YOUR meds against Li Dan Pian?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,304Drugs
1,209 Moderate 95 Minor

Ingredients driving the most interactions

Scutellaria baicalensis 946
Rheum palmatum 658
Bupleurum chinense 327
Inula helenium 248
Artemisia capillaris 248

Individual Drug Interactions

The ingredients in Li Dan Pian interact with 1,304 drugs. Click any drug to see the details.

6 of the 8 ingredients in Li Dan Pian interact with drugs. Each result below shows which ingredient is responsible. Scutellaria baicalensis Rheum palmatum Bupleurum chinense Inula helenium Artemisia capillaris Lonicera japonica

Each ingredient & the kinds of drugs it affects

For each ingredient in Li Dan Pian with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Scutellaria baicalensis12 drug types · 946 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Preliminary clinical research suggests that taking capsules containing a combination of astragalus, goldthread, and Baikal skullcap daily for 4 weeks inhibits platelet aggregation; the effect seems to be similar to that of aspirin 50 mg daily. It is unclear if this effect is due to Baikal skullcap, other ingredients, or the combination.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro. Animal research also suggests that Baikal skullcap enhances the antidiabetic effects of metformin. However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT). Until more is known, use cautiously.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that baicalein, a constituent of Baikal skullcap, might lower blood pressure.

Likelihood Possible Evidence D
Antithyroid Drugs

Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
In vitro evidence suggests that constituents of Baikal skullcap inhibit the activity of CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.
In vitro evidence suggest that wogonin, a constituent of Baikal skullcap, modestly inhibits the activity of CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of Baikal skullcap might interfere with hormone replacement therapy, due to competition for estrogen receptors.
In vitro evidence suggests that Baikal skullcap has estrogenic activity.

Likelihood Possible Evidence D
Lithium

Theoretically, Baikal skullcap might reduce lithium excretion and increase serum levels of lithium.
Baikal skullcap is thought to have diuretic properties, which may reduce lithium excretion. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Alcohol (Ethanol)

Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.

Likelihood Unlikely Evidence D
Cns Depressants

Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.

Likelihood Unlikely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, Baikal skullcap might alter the levels and clinical effects of OATP substrates.
Some pharmacokinetic research shows that baicalin, a constituent of Baikal skullcap, can decrease plasma levels of rosuvastatin. The mechanism is thought to involve stimulation of the activity of the organic anion-transporting polypeptide 1B1 (OATP1B1), which transports rosuvastatin into the liver. This decreases plasma levels of the drug, but increases levels at the site of action in the liver. The degree to which rosuvastatin levels are affected depends on the OATP1B1 haplotype of the individual. Baikal skullcap might also affect other OATP1B1 substrates.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
In vitro and animal research suggests that baicalein, oroxylin A, and wogonin, constituents of Baikal skullcap, can inhibit P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Scutellaria baicalensis full monograph & interactions

Rheum palmatum8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Rheum palmatum full monograph & interactions

Bupleurum chinense3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that saikosaponins, constituents of bupleurum, can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bupleurum might decrease the effects of antidiabetes drugs.
Animal research suggests that saikosaponins, constituents of bupleurum, can increase blood glucose.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, bupleurum might decrease the effects of immunosuppressants.
In vitro and animal research suggests that bupleurum might stimulate immune function.

Likelihood Possible Evidence D
Bupleurum chinense full monograph & interactions

Inula helenium1 drug type · 248 drugs

Cns Depressants

Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.
Elecampane might have sedative effects.

Likelihood Possible Evidence D
Inula helenium full monograph & interactions

Artemisia capillaris2 drug types · 248 drugs

Cns Depressants

Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.
Animal research shows that yin chen has sedative effects and can reduce motor activity and impair balance and coordination. When used in combination with pentobarbital, yin chen increases sleeping time when compared to pentobarbital alone.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, yin chen might enhance the therapeutic and adverse effects of pentobarbital.
Animal research shows that yin chen, given orally in combination with pentobarbital, can increase sleeping time compared to pentobarbital alone.

Likelihood Possible Evidence D
Artemisia capillaris full monograph & interactions

Lonicera japonica1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that polyphenols extracted from honeysuckle can inhibit platelet aggregation.

Likelihood Possible Evidence D
Lonicera japonica full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Li Dan Pian, from the product label.

Plum Flower

Name
Mayway Corp.
City
Oakland
State
CA
ZipCode
94607
Web Address
www.plumflowerherbs.com
Pharmacist Counseling Corner

Li Dan Pian by Plum Flower: Common Questions

Does Li Dan Pian by Plum Flower interact with any medications?
Yes. Based on its ingredients, Li Dan Pian has a known interaction with 1,304 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Li Dan Pian contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Safety data are insufficient or advise against use for the ingredients in this product during pregnancy. Rhubarb is rated possibly unsafe in pregnancy. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
There isn't enough safety data for any of the ingredients in this product during breastfeeding. Rhubarb's laxative compounds may pass into breast milk. Discuss this with your pharmacist or doctor.
Does this product actually work?
The evidence we hold shows insufficient reliable evidence for most uses in this formula. Rhubarb has a possibly effective rating for pancreatitis and menopausal symptoms, and Isatis for psoriasis. The other ingredients lack established effectiveness ratings in our data.
What side effects might I experience?
The most common side effects are digestive — abdominal pain, cramping, diarrhea, nausea, and vomiting. Allergic reactions, including skin rashes and contact dermatitis, have been reported. Rare serious effects include liver damage and lung problems, though these are uncommon.
Why does this product interact with so many medications?
Several ingredients, especially Baikal Skullcap and Rhubarb, affect how your liver processes drugs or how your blood clots, and they may lower blood pressure or blood sugar. These broad effects mean they can theoretically interact with many different medication types.
What is Rhubarb doing in this formula?
Rhubarb is included for its traditional use; it has a laxative effect and shows possibly effective evidence for pancreatitis and menopausal symptoms. However, it's not safe to use long-term and can cause potassium loss and other complications with frequent or high doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Li Dan Pian label
Go deeper

The Full Monographs Behind Li Dan Pian’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Baikal Skullcap

Interacts with 946 drugs

Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baicalin and baicalein studied mostly in the lab. Human...

Read the full Baikal Skullcap monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph → Herb & supplement monograph

Elecampane

Interacts with 248 drugs

Elecampane is a traditional herb used mainly for coughs and other respiratory complaints, and as a bitter for digestion. Modern human evidence is very limited, so it should be seen as a folk...

Read the full Elecampane monograph → Herb & supplement monograph

Honeysuckle

Interacts with 122 drugs

Honeysuckle, especially Japanese honeysuckle flower (Lonicera japonica), is a staple of traditional Chinese medicine used mainly for colds, sore throat, and inflammation. Modern human eviden...

Read the full Honeysuckle monograph → Herb & supplement monograph

Bupleurum

Interacts with 327 drugs

Bupleurum (Chai Hu) is a root used in traditional Chinese medicine, usually as part of multi-herb formulas, for liver, digestive, and fever-related complaints. High-quality human evidence fo...

Read the full Bupleurum monograph → Herb & supplement monograph

Yin Chen

Interacts with 248 drugs

Yin Chen is a traditional Chinese medicine herb used mainly for liver and gallbladder complaints and jaundice. Most of the evidence comes from laboratory and animal studies, so its benefits...

Read the full Yin Chen monograph → Herb & supplement monograph

Isatis

Isatis is a plant long used in traditional Chinese medicine, mainly for sore throats, fevers, and colds. Modern evidence in people is very limited, so its benefits are not well proven. Talk...

Read the full Isatis monograph →
Sources

Sources & How We Checked

Li Dan Pian's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 86 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Baikal Skullcap 34 references
  1. Huang KC. The pharmacology of Chinese herbs. 2nd ed. New York, NY: CRC Press LLC. 1999;385-6, 400-1.
  2. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. Planta Med 2000;66:91-3.
  3. Liao JF, Wang HH, Chen MC, et al. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 1998;64:571-2.
  4. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 1998;61:1413-5.
  5. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  6. Fan L, Zhang W, Guo D, et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Clin Pharmacol Ther 2007;83:471-6. PubMed
  7. Chen C, Mireles RJ, Campbell SD, et al. Differential interaction of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos 2005;33:537-46. PubMed
  8. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther 2007;82:726-33. PubMed
  9. Konig J, Seithel A, Gradhand U, Fromm MF. Pharmacogenomics of human OATP transporters. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. PubMed
  10. Chalasani N, Vuppalanchi R, Navarro V, et al. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. Ann Intern Med 2012;156:857-60. PubMed
  11. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Ann Intern Med 2012;156:894-5. PubMed
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See these in context on the Baikal Skullcap monograph →

Rhubarb 20 references
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See these in context on the Rhubarb monograph →

Elecampane 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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Honeysuckle 3 references
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Bupleurum 17 references
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See these in context on the Bupleurum monograph →

Yin Chen 4 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
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See these in context on the Yin Chen monograph →

Isatis 3 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

See these in context on the Isatis monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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