Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Lion's Mane Ingredients & Drug Interactions

by Om Mushroom Superfood

Lion's Mane label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane is a dietary supplement by Om Mushroom Superfood with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lion's Mane by Om Mushroom Superfood

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane by Om Mushroom Superfood — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Lion's Mane by Om Mushroom Superfood

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Certified Organic Mushroom Powder Blend” is a proprietary blend — the label gives one combined amount (2 Gram(s)) without saying how much of each component you get.

This product contains 2 active ingredients. The first is Lion's Mane mushroom itself — the whole reason you're taking it — which is the fruiting body extract that research has been studying.

The second is listed as a Certified Organic Mushroom Powder Blend, which is a blend container whose specific components aren't broken out separately in what we have on file. The inactive ingredients are cellulose (a capsule binder) and myceliated oats (oats colonized by mushroom mycelium, used as a base).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Mental clarity, focus and alertness.
  • We looked for evidence on: Cognitive function, Memory, Anxiety, Depression, Concentration, Brain health — and 1 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Depression, Memory.

Here's the honest part: the evidence for lion's mane hasn't been established yet in the data we hold. For all six conditions studied — Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment — the rating is insufficient reliable evidence.

That doesn't mean it doesn't work; it means the research so far isn't solid enough for us to say. If you're curious about what's being researched, that's worth a conversation with your pharmacist.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane is generally well tolerated as a food. As a supplement, though, long-term safety hasn't been well studied, so caution is warranted if you plan to take it regularly.

A small number of people report gastrointestinal discomfort, nausea, or skin rash. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in those situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us if you take blood thinners (warfarin, aspirin, clopidogrel), diabetes medications (metformin, insulin, sulfonylureas), or immunosuppressant drugs (tacrolimus, mycophenolate). All three drug types have moderate-level interaction concerns with lion's mane.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is generally well tolerated as a food, but evidence for its effectiveness isn't established yet. If you take blood thinners, diabetes medications, or immunosuppressants, check your exact drugs with us first — the interactions are moderate-level concerns.

Pregnant or breastfeeding? Skip this one.

Talk to your pharmacist about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane, straight from the product label.

Brand Om Mushroom Superfood
Barcode (UPC) 856210008158
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 318044
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane by Om Mushroom Superfood, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
856210008158
IngredientAmount% DV
Lion's Mane0 NP--
Certified Organic Mushroom Powder Blend2 Gram(s)--
Lion's Mane0 NP--

Other ingredients: Cellulose, myceliated Oats

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Mental Clarity Focus & Alertness The smartest mushroom in the kingdom. Lion's Mane can help spark cognition, focus and clarity. Om Lion's Mane Capsules are a smart way to help fuel your brain. We grow our om. We grow a diverse range of mushroom species at our indoor farm in California and capture the complete nutritional value of the growing cycle. Whole food mushrooms are important because they provide a full spectrum of active compounds to support optimal health. Whole food nutrition

Tested for heavy metals

Non GMO Project Verified nongmoproject.org Gf Gluten free

Memory Focus Nerve health Mushroom superfood Daily boost capsules

V Vegan

Formula

Lion's Mane Beta glucans and prebiotics

Om grown 2,000mg per serving Mushroom blend See Supplement Facts

EarthKosher Certified Kosher by Earth Kosher

Keto Keto-friendly Pf Paleo-friendly

General Statements

Scan code to learn more 30 Day Supply

Facebook Instagram @OmMushrooms OmMushrooms.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Non GMO Project Verified nongmoproject.org USA Grown Mushrooms

EarthKosher Certified Kosher by Earth Kosher

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take three (3) capsules per day with a glass of water. Take as directed

Precautions

If you have a medical condition, are on medication or are pregnant or nursing, please seek the direction of a qualified health care professional before using.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane by Om Mushroom Superfood label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane by Om Mushroom Superfood

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Certified Organic Mushroom Powder Blend

2 Gram(s) per serving

Other (inactive) ingredients: Cellulose, Myceliated Oats. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane by Om Mushroom Superfood Drug Interactions

Want to check YOUR meds against Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane 327

Individual Drug Interactions

The ingredients in Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane, from the product label.

Om Mushroom Superfood

See all Om Mushroom Superfood products
Name
M2 Ingredients
City
Carlsbad
State
CA
ZipCode
92008
Pharmacist Counseling Corner

Lion's Mane by Om Mushroom Superfood: Common Questions

Does Lion's Mane by Om Mushroom Superfood interact with any medications?
Yes. Based on its ingredients, Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does lion's mane actually work for memory or cognitive function?
The evidence isn't established yet in the research we have on file. For memory, cognitive function, and cognitive impairment, we don't have enough reliable data to say whether it works. If that's what you're considering it for, it's worth discussing with your pharmacist what the current research suggests.
Is it safe to take while pregnant or breastfeeding?
No. There isn't enough safety data, so the guidance is to avoid it during pregnancy and while breastfeeding. Talk to your OB or midwife if you're interested in it for a specific reason — they can advise you on whether to wait.
What side effects might I notice?
Most people tolerate it well. The ones that do show up are usually mild: gastrointestinal discomfort, nausea, or occasionally a skin rash. Start with the recommended dose and see how you feel.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking first. Lion's mane may increase bleeding risk because it can slow how your blood clots. Your pharmacist needs to review your exact medication and dose before you start.
What does 'myceliated oats' mean in the inactive ingredients?
Those are oats that have been colonized by mushroom mycelium — essentially the mushroom root system grown through the oats. They're used as a base to grow and stabilize the lion's mane extract. They're an inactive ingredient, not an active one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane label
Go deeper

The Full Monographs Behind Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team